vascular disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. (Human Disease Ontology, DOID_178)
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Genes

325 genes associated with the disease vascular disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PROCR protein C receptor, endothelial 2.83628
FGG fibrinogen gamma chain 2.66306
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.60909
FGA fibrinogen alpha chain 2.54174
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 2.43719
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.41711
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.25831
F11 coagulation factor XI 2.10316
CCND3 cyclin D3 2.05106
FGB fibrinogen beta chain 2.0208
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.0208
PLRG1 pleiotropic regulator 1 1.92766
PROC protein C (inactivator of coagulation factors Va and VIIIa) 1.91829
ITFG3 integrin alpha FG-GAP repeat containing 3 1.909
RPL6 ribosomal protein L6 1.90585
MMP3 matrix metallopeptidase 3 1.86151
F12 coagulation factor XII (Hageman factor) 1.76631
CSK c-src tyrosine kinase 1.52269
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 1.51016
ICAM1 intercellular adhesion molecule 1 1.49392
ZFPM2 zinc finger protein, FOG family member 2 1.48894
ODF3B outer dense fiber of sperm tails 3B 1.48894
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 1.4851
STXBP5 syntaxin binding protein 5 (tomosyn) 1.47477
FGF5 fibroblast growth factor 5 1.43901
KNG1 kininogen 1 1.43901
BLK BLK proto-oncogene, Src family tyrosine kinase 1.40325
TFR2 transferrin receptor 2 1.37597
HK1 hexokinase 1 1.35663
SYCE2 synaptonemal complex central element protein 2 1.341
RCL1 RNA terminal phosphate cyclase-like 1 1.33613
PRKCE protein kinase C, epsilon 1.31515
TFRC transferrin receptor 1.29735
PDGFD platelet derived growth factor D 1.27521
ARHGAP42 Rho GTPase activating protein 42 1.24299
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.24299
PLG plasminogen 1.2206
LPA lipoprotein, Lp(a) 1.14929
TWIST1 twist family bHLH transcription factor 1 1.14929
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase 1.14929
OR10Z1 olfactory receptor, family 10, subfamily Z, member 1 1.12703
THRB thyroid hormone receptor, beta 1.1139
HBS1L HBS1-like translational GTPase 1.09588
NT5C2 5'-nucleotidase, cytosolic II 1.09588
HFE hemochromatosis 1.07383
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 1.07383
LPL lipoprotein lipase 1.04495
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.03105
G6PD glucose-6-phosphate dehydrogenase 1.02486
PSRC1 proline/serine-rich coiled-coil 1 0.995303
SH2B3 SH2B adaptor protein 3 0.995303
APOC1 apolipoprotein C-I 0.987984
GCKR glucokinase (hexokinase 4) regulator 0.971299
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.945428
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.945428
LOC340340 uncharacterized LOC340340 0.945428
FBXO7 F-box protein 7 0.932337
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.932337
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.923046
RBM38 RNA binding motif protein 38 0.923046
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 0.916033
FBN1 fibrillin 1 0.910378
APOB apolipoprotein B 0.897589
RP1 retinitis pigmentosa 1 (autosomal dominant) 0.894262
C5ORF56 chromosome 5 open reading frame 56 0.894262
TMPRSS6 transmembrane protease, serine 6 0.894262
RBBP8 retinoblastoma binding protein 8 0.894262
NME7 NME/NM23 family member 7 0.872896
DCHS2 dachsous cadherin-related 2 0.872896
MAX MYC associated factor X 0.872896
HIST1H1T histone cluster 1, H1t 0.872896
ITPKC inositol-trisphosphate 3-kinase C 0.872896
CHURC1 churchill domain containing 1 0.872896
ADM adrenomedullin 0.85991
ZPR1 ZPR1 zinc finger 0.850113
CCND2 cyclin D2 0.825265
HRG histidine-rich glycoprotein 0.817078
EBF1 early B-cell factor 1 0.817078
IL6R interleukin 6 receptor 0.790827
BAG6 BCL2-associated athanogene 6 0.790827
HDAC9 histone deacetylase 9 0.790827
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 0.790827
RASA2 RAS p21 protein activator 2 0.7623
UMOD uromodulin 0.7623
FIGN fidgetin 0.7623
ACOXL acyl-CoA oxidase-like 0.7623
HLA-DOB major histocompatibility complex, class II, DO beta 0.752991
KITLG KIT ligand 0.745324
SYK spleen tyrosine kinase 0.738873
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.738873
CD300LF CD300 molecule-like family member f 0.73332
RAB37 RAB37, member RAS oncogene family 0.73332
NKX2-3 NK2 homeobox 3 0.724323
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.724323
SOX17 SRY (sex determining region Y)-box 17 0.724323
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 0.724323
GOSR2 golgi SNAP receptor complex member 2 0.724323
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.724323
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 0.69843
CPLX3 complexin 3 0.69843
HEYL hes-related family bHLH transcription factor with YRPW motif-like 0.682635
CBS cystathionine-beta-synthase 0.682635
NRG4 neuregulin 4 0.682635
MIA melanoma inhibitory activity 0.670996
C4BPB complement component 4 binding protein, beta 0.670996
DAB2IP DAB2 interacting protein 0.661797
TRIM58 tripartite motif containing 58 0.661797
PCCB propionyl CoA carboxylase, beta polypeptide 0.65413
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.641775
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.63666
CDH13 cadherin 13 0.63207
C10ORF107 chromosome 10 open reading frame 107 0.63207
MOV10 Mov10 RISC complex RNA helicase 0.63207
SMOC1 SPARC related modular calcium binding 1 0.63207
NINJ2 ninjurin 2 0.63207
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.63207
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.602429
ADRB1 adrenoceptor beta 1 0.602429
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.602429
STARD13 StAR-related lipid transfer (START) domain containing 13 0.58494
ULK4 unc-51 like kinase 4 0.58494
F5 coagulation factor V (proaccelerin, labile factor) 0.58494
DENND4A DENN/MADD domain containing 4A 0.58494
VMP1 vacuole membrane protein 1 0.58494
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.58494
NOV nephroblastoma overexpressed 0.572184
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.572184
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.572184
OR51V1 olfactory receptor, family 51, subfamily V, member 1 0.561725
PLCE1 phospholipase C, epsilon 1 0.561725
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.561725
MYB v-myb avian myeloblastosis viral oncogene homolog 0.552621
POC1B POC1 centriolar protein B 0.544585
PTPRC protein tyrosine phosphatase, receptor type, C 0.537125
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.5306
PLCD3 phospholipase C, delta 3 0.52461
CCDC162P coiled-coil domain containing 162, pseudogene 0.52461
NLRP3 NLR family, pyrin domain containing 3 0.52461
EDNRA endothelin receptor type A 0.52461
SCARB1 scavenger receptor class B, member 1 0.52461
RPL21P44 ribosomal protein L21 pseudogene 44 0.52461
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.52461
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.52461
NPR3 natriuretic peptide receptor 3 0.486425
ATXN2 ataxin 2 0.486425
FMR1 fragile X mental retardation 1 0.486425
RNF213 ring finger protein 213 0.486425
MAP4 microtubule-associated protein 4 0.464771
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.464771
LRRC7 leucine rich repeat containing 7 0.464771
CENPU centromere protein U 0.464771
CETP cholesteryl ester transfer protein, plasma 0.464771
FES FES proto-oncogene, tyrosine kinase 0.464771
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.464771
NUP205 nucleoporin 205kDa 0.464771
AGBL1 ATP/GTP binding protein-like 1 0.449873
PABPC5 poly(A) binding protein, cytoplasmic 5 0.449873
BOLL boule-like RNA-binding protein 0.449873
COL4A1 collagen, type IV, alpha 1 0.438544
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene 0.438544
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.438544
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.438544
ASB3 ankyrin repeat and SOCS box containing 3 0.438544
CD40 CD40 molecule, TNF receptor superfamily member 5 0.438544
FSTL4 follistatin-like 4 0.408752
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.403461
PHACTR1 phosphatase and actin regulator 1 0.403461
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.403461
MECOM MDS1 and EVI1 complex locus 0.403461
TRAFD1 TRAF-type zinc finger domain containing 1 0.403461
PARP14 poly (ADP-ribose) polymerase family, member 14 0.368757
ZNF652 zinc finger protein 652 0.368757
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.368757
BRAP BRCA1 associated protein 0.368757
DAW1 dynein assembly factor with WDR repeat domains 1 0.368757
PDYN prodynorphin 0.368757
CASZ1 castor zinc finger 1 0.368757
ZNF831 zinc finger protein 831 0.368757
TNC tenascin C 0.368757
ANKRD44 ankyrin repeat domain 44 0.368757
STK39 serine threonine kinase 39 0.368757
DOCK7 dedicator of cytokinesis 7 0.345945
PLCL1 phospholipase C-like 1 0.345945
TECRL trans-2,3-enoyl-CoA reductase-like 0.345945
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.345945
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.345945
ABI2 abl-interactor 2 0.327313
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.327313
F8 coagulation factor VIII, procoagulant component 0.327313
TMEM212 transmembrane protein 212 0.327313
OSBPL10 oxysterol binding protein-like 10 0.311576
PRKCH protein kinase C, eta 0.311576
MED30 mediator complex subunit 30 0.311576
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.311576
LIPC lipase, hepatic 0.311576
EFHB EF-hand domain family, member B 0.311576
ITGA9 integrin, alpha 9 0.311576
ARHGAP18 Rho GTPase activating protein 18 0.297866
GLRX3 glutaredoxin 3 0.297866
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 0.297866
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.285417
C2ORF88 chromosome 2 open reading frame 88 0.285417
MYO16 myosin XVI 0.285417
LDLR low density lipoprotein receptor 0.285417
APOA5 apolipoprotein A-V 0.274608
RGS1 regulator of G-protein signaling 1 0.264872
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.264872
COL4A2 collagen, type IV, alpha 2 0.264872
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.256228
BARHL2 BarH-like homeobox 2 0.256228
AP3B2 adaptor-related protein complex 3, beta 2 subunit 0.256228
PRRX1 paired related homeobox 1 0.256228
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.256228
NRXN1 neurexin 1 0.256228
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.256228
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.256228
RGMA repulsive guidance molecule family member a 0.256228
FOXD3 forkhead box D3 0.197766
CNTN6 contactin 6 0.197766
FRY furry homolog (Drosophila) 0.197766
PELI1 pellino E3 ubiquitin protein ligase 1 0.197766
NEBL nebulette 0.197766
JAKMIP1 janus kinase and microtubule interacting protein 1 0.197766
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 0.197766
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.197766
AP3M2 adaptor-related protein complex 3, mu 2 subunit 0.197766
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.197766
WDFY4 WDFY family member 4 0.197766
GPC6 glypican 6 0.197766
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 0.197766
GPR83 G protein-coupled receptor 83 0.197766
ZNF536 zinc finger protein 536 0.197766
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 0.197766
SYNRG synergin, gamma 0.197766
ZFHX3 zinc finger homeobox 3 0.197766
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.197766
UST uronyl-2-sulfotransferase 0.197766
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.15771
FTMT ferritin mitochondrial 0.15771
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.15771
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.15771
DLG2 discs, large homolog 2 (Drosophila) 0.15771
NCKAP5 NCK-associated protein 5 0.15771
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.15771
MYL12B myosin, light chain 12B, regulatory 0.15771
OTUD7A OTU deubiquitinase 7A 0.15771
TSC22D1 TSC22 domain family, member 1 0.15771
MEF2C myocyte enhancer factor 2C 0.15771
PCSK2 proprotein convertase subtilisin/kexin type 2 0.15771
BET1L Bet1 golgi vesicular membrane trafficking protein-like 0.15771
KALRN kalirin, RhoGEF kinase 0.15771
GPATCH2L G patch domain containing 2-like 0.15771
CNTNAP5 contactin associated protein-like 5 0.15771
SUSD1 sushi domain containing 1 0.15771
MSRA methionine sulfoxide reductase A 0.126165
KATNAL1 katanin p60 subunit A-like 1 0.126165
CDK14 cyclin-dependent kinase 14 0.126165
KDM4A lysine (K)-specific demethylase 4A 0.126165
CNTN4 contactin 4 0.126165
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.126165
KIF20B kinesin family member 20B 0.126165
TNR tenascin R 0.126165
LPAR3 lysophosphatidic acid receptor 3 0.126165
C20ORF196 chromosome 20 open reading frame 196 0.126165
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.126165
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.100789
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.100789
DNAH5 dynein, axonemal, heavy chain 5 0.100789
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.100789
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.100789
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.100789
MYO1D myosin ID 0.100789
RNF157 ring finger protein 157 0.100789
PCGF5 polycomb group ring finger 5 0.080593
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.080593
COL8A1 collagen, type VIII, alpha 1 0.080593
C3ORF56 chromosome 3 open reading frame 56 0.080593
NUMB numb homolog (Drosophila) 0.080593
IQSEC3 IQ motif and Sec7 domain 3 0.080593
MEOX2 mesenchyme homeobox 2 0.080593
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.080593
EYA4 EYA transcriptional coactivator and phosphatase 4 0.080593
TMC7 transmembrane channel-like 7 0.080593
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.064973
IGHV2-70 immunoglobulin heavy variable 2-70 0.064973
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.064973
ADCY8 adenylate cyclase 8 (brain) 0.064973
BMPR1B bone morphogenetic protein receptor, type IB 0.064973
BTBD1 BTB (POZ) domain containing 1 0.064973
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.064973
IDI2 isopentenyl-diphosphate delta isomerase 2 0.052255
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.052255
IGFBPL1 insulin-like growth factor binding protein-like 1 0.052255
SYNE1 spectrin repeat containing, nuclear envelope 1 0.052255
LPAR1 lysophosphatidic acid receptor 1 0.052255
SV2C synaptic vesicle glycoprotein 2C 0.052255
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.052255
MRPS22 mitochondrial ribosomal protein S22 0.052255
OMA1 OMA1 zinc metallopeptidase 0.052255
EXOC4 exocyst complex component 4 0.052255
FZD8 frizzled class receptor 8 0.043246
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.043246
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.043246
AIM1 absent in melanoma 1 0.043246
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.043246
WNT9B wingless-type MMTV integration site family, member 9B 0.043246
KIAA0020 KIAA0020 0.043246
TBPL2 TATA box binding protein like 2 0.043246
RPL14P1 ribosomal protein L14 pseudogene 1 0.043246
GPR137B G protein-coupled receptor 137B 0.035343
CIDEA cell death-inducing DFFA-like effector a 0.035343
C12ORF42 chromosome 12 open reading frame 42 0.002352
MRPS6 mitochondrial ribosomal protein S6 0.002189
MIA3 melanoma inhibitory activity family, member 3 0.001569
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.001447
CXCL12 chemokine (C-X-C motif) ligand 12 0.001225
WDR12 WD repeat domain 12 0.001162
MARC1 mitochondrial amidoxime reducing component 1 6.79E-4
RCSD1 RCSD domain containing 1 6.25E-4
CLEC14A C-type lectin domain family 14, member A 5.68E-4
TENM1 teneurin transmembrane protein 1 4.92E-4
PPP4R2 protein phosphatase 4, regulatory subunit 2 4.92E-4
LZTS1 leucine zipper, putative tumor suppressor 1 4.52E-4
SETBP1 SET binding protein 1 4.25E-4
LTA lymphotoxin alpha 1.0E-4