valproic acid-6168 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the valproic acid-6168 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ACSS3 acyl-CoA synthetase short-chain family member 3
AHI1 Abelson helper integration site 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOM apolipoprotein M
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BNC2 basonuclin 2
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD1E CD1e molecule
CDKL5 cyclin-dependent kinase-like 5
CHRM4 cholinergic receptor, muscarinic 4
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSPG4 chondroitin sulfate proteoglycan 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAPK3 death-associated protein kinase 3
DDR1 discoidin domain receptor tyrosine kinase 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DLG3 discs, large homolog 3 (Drosophila)
EFNB3 ephrin-B3
ETV7 ets variant 7
FBXL7 F-box and leucine-rich repeat protein 7
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLJ11292
FRMD8 FERM domain containing 8
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAMP hepcidin antimicrobial peptide
HBE1 hemoglobin, epsilon 1
HRASLS HRAS-like suppressor
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KLF3 Kruppel-like factor 3 (basic)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOXL2 lysyl oxidase-like 2
LOXL3 lysyl oxidase-like 3
LPAR1 lysophosphatidic acid receptor 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGEA5 melanoma antigen family A5
MOBP myelin-associated oligodendrocyte basic protein
MYO1B myosin IB
NCLN nicalin
NEBL nebulette
NRCAM neuronal cell adhesion molecule
OSBP2 oxysterol binding protein 2
OXCT2 3-oxoacid CoA transferase 2
PAX2 paired box 2
PDCD6 programmed cell death 6
PDE8B phosphodiesterase 8B
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PRPH2 peripherin 2 (retinal degeneration, slow)
PRSS16 protease, serine, 16 (thymus)
RAB13 RAB13, member RAS oncogene family
RBMS3 RNA binding motif, single stranded interacting protein 3
RDH16 retinol dehydrogenase 16 (all-trans)
RET ret proto-oncogene
RGS12 regulator of G-protein signaling 12
RHOBTB3 Rho-related BTB domain containing 3
RPL10L ribosomal protein L10-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAMD4A sterile alpha motif domain containing 4A
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A17 solute carrier family 22, member 17
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SMAD3 SMAD family member 3
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPPL2B signal peptide peptidase like 2B
SSTR5 somatostatin receptor 5
STEAP4 STEAP family member 4
STK17A serine/threonine kinase 17a
STX2 syntaxin 2
SYNPO synaptopodin
TCP10 t-complex 10
TFF2 trefoil factor 2
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TLR5 toll-like receptor 5
TMEM47 transmembrane protein 47
TRAPPC9 trafficking protein particle complex 9
TULP1 tubby like protein 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS9D1 VPS9 domain containing 1
WFDC2 WAP four-disulfide core domain 2
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YBX2 Y box binding protein 2
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADTRP androgen-dependent TFPI-regulating protein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALPK1 alpha-kinase 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARMC6 armadillo repeat containing 6
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
AVPI1 arginine vasopressin-induced 1
BTBD18 BTB (POZ) domain containing 18
C10ORF88 chromosome 10 open reading frame 88
C11ORF68 chromosome 11 open reading frame 68
CD1C CD1c molecule
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CHML choroideremia-like (Rab escort protein 2)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CPA4 carboxypeptidase A4
CTAGE9 CTAGE family, member 9
CTSO cathepsin O
CTSV cathepsin V
CUL9 cullin 9
CYSLTR1 cysteinyl leukotriene receptor 1
DDN dendrin
DNMBP dynamin binding protein
ECHDC2 enoyl CoA hydratase domain containing 2
EDC4 enhancer of mRNA decapping 4
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EXD3 exonuclease 3'-5' domain containing 3
FAM50B family with sequence similarity 50, member B
FBXL15 F-box and leucine-rich repeat protein 15
FHL3 four and a half LIM domains 3
FSTL3 follistatin-like 3 (secreted glycoprotein)
FURIN furin (paired basic amino acid cleaving enzyme)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLCE glucuronic acid epimerase
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H1B histone cluster 1, H1b
HIST2H2AA3 histone cluster 2, H2aa3
HOXA1 homeobox A1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFT46 intraflagellar transport 46
INO80D INO80 complex subunit D
ITPKC inositol-trisphosphate 3-kinase C
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0319L KIAA0319-like
KIAA0753 KIAA0753
LAMB3 laminin, beta 3
LIN7B lin-7 homolog B (C. elegans)
LOC390998 ribosomal protein L10 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
METTL21B methyltransferase like 21B
METTL2B methyltransferase like 2B
MOCS3 molybdenum cofactor synthesis 3
MON1B MON1 secretory trafficking family member B
MTA2 metastasis associated 1 family, member 2
NBEAL2 neurobeachin-like 2
NOD1 nucleotide-binding oligomerization domain containing 1
NSUN6 NOP2/Sun domain family, member 6
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PFN2 profilin 2
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAMEF11 PRAME family member 11
PROCR protein C receptor, endothelial
PSKH1 protein serine kinase H1
RAB3A RAB3A, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RHOBTB1 Rho-related BTB domain containing 1
RIN1 Ras and Rab interactor 1
SAMD9 sterile alpha motif domain containing 9
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
TBC1D17 TBC1 domain family, member 17
TM7SF2 transmembrane 7 superfamily member 2
TMEM39B transmembrane protein 39B
TMEM57 transmembrane protein 57
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TRIM66 tripartite motif containing 66
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPAN13 tetraspanin 13
TSPAN5 tetraspanin 5
TUBB2A tubulin, beta 2A class IIa
USP18 ubiquitin specific peptidase 18
ZC4H2 zinc finger, C4H2 domain containing
ZHX2 zinc fingers and homeoboxes 2
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF10 zinc finger protein 10
ZNF493 zinc finger protein 493
ZNF510 zinc finger protein 510