valproic acid-5574 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the valproic acid-5574 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ACACB acetyl-CoA carboxylase beta
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDOB aldolase B, fructose-bisphosphate
AQP4 aquaporin 4
ATAT1 alpha tubulin acetyltransferase 1
BGN biglycan
C14ORF105 chromosome 14 open reading frame 105
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CD248 CD248 molecule, endosialin
CD48 CD48 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDHR2 cadherin-related family member 2
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLDN17 claudin 17
CLIC2 chloride intracellular channel 2
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CTNS cystinosin, lysosomal cystine transporter
CYHR1 cysteine/histidine-rich 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCHS2 dachsous cadherin-related 2
DFNB31 deafness, autosomal recessive 31
DLL3 delta-like 3 (Drosophila)
DLX2 distal-less homeobox 2
DNAH7 dynein, axonemal, heavy chain 7
DPF1 D4, zinc and double PHD fingers family 1
DRD2 dopamine receptor D2
DTX3 deltex 3, E3 ubiquitin ligase
DZIP1 DAZ interacting zinc finger protein 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FADS3 fatty acid desaturase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGFR1OP FGFR1 oncogene partner
FRMPD1 FERM and PDZ domain containing 1
FSCN1 fascin actin-bundling protein 1
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GGT1 gamma-glutamyltransferase 1
GJA9 gap junction protein, alpha 9, 59kDa
GP2 glycoprotein 2 (zymogen granule membrane)
HAB1 B1 for mucin
HFE hemochromatosis
HP haptoglobin
INHA inhibin, alpha
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRS4 insulin receptor substrate 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCTD17 potassium channel tetramerization domain containing 17
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LAMA4 laminin, alpha 4
LAT2 linker for activation of T cells family, member 2
LEFTY2 left-right determination factor 2
LHX1 LIM homeobox 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRP12 low density lipoprotein receptor-related protein 12
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MUC6 mucin 6, oligomeric mucus/gel-forming
MVB12B multivesicular body subunit 12B
NELL2 NEL-like 2 (chicken)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NRG1 neuregulin 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUDCD3 NudC domain containing 3
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDGFD platelet derived growth factor D
PEG3 paternally expressed 3
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PQLC3 PQ loop repeat containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
RIMS2 regulating synaptic membrane exocytosis 2
RLN1 relaxin 1
RUFY3 RUN and FYVE domain containing 3
RUNX1 runt-related transcription factor 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
SLURP1 secreted LY6/PLAUR domain containing 1
SSX3 synovial sarcoma, X breakpoint 3
SYNPO synaptopodin
TBXA2R thromboxane A2 receptor
TCF3 transcription factor 3
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP63 tumor protein p63
TUBA3C tubulin, alpha 3c
VGLL3 vestigial-like family member 3
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
APH1A APH1A gamma secretase subunit
APOLD1 apolipoprotein L domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP11B ATPase, class VI, type 11B
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX4 chromobox homolog 4
CCDC69 coiled-coil domain containing 69
CCNO cyclin O
CHKB choline kinase beta
CLDN15 claudin 15
CLSPN claspin
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRLF1 cytokine receptor-like factor 1
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF17 DDB1 and CUL4 associated factor 17
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
ERCC6 excision repair cross-complementation group 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO46 F-box protein 46
FBXO5 F-box protein 5
FOXC1 forkhead box C1
GSTCD glutathione S-transferase, C-terminal domain containing
HCFC1 host cell factor C1
HOXA4 homeobox A4
KAT2A K(lysine) acetyltransferase 2A
KLF2 Kruppel-like factor 2
KPNA4 karyopherin alpha 4 (importin alpha 3)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC100286895 cell division cycle 27 homolog pseudogene
LUC7L LUC7-like (S. cerevisiae)
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NEK11 NIMA-related kinase 11
NT5DC3 5'-nucleotidase domain containing 3
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PGP phosphoglycolate phosphatase
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
POLL polymerase (DNA directed), lambda
PROS1 protein S (alpha)
PTDSS2 phosphatidylserine synthase 2
PTPRS protein tyrosine phosphatase, receptor type, S
PYCRL pyrroline-5-carboxylate reductase-like
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
RSF1 remodeling and spacing factor 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC3 syndecan 3
SGCE sarcoglycan, epsilon
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGMS1 sphingomyelin synthase 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLMO1 slowmo homolog 1 (Drosophila)
SREBF1 sterol regulatory element binding transcription factor 1
TBX19 T-box 19
TCTN1 tectonic family member 1
TESK1 testis-specific kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TLR5 toll-like receptor 5
TM6SF1 transmembrane 6 superfamily member 1
TMEM104 transmembrane protein 104
TMEM120B transmembrane protein 120B
TMEM2 transmembrane protein 2
TMEM53 transmembrane protein 53
TMEM62 transmembrane protein 62
TPTE transmembrane phosphatase with tensin homology
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM25 tripartite motif containing 25
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UNKL unkempt family zinc finger-like
VPS9D1 VPS9 domain containing 1
WDR43 WD repeat domain 43
ZBTB44 zinc finger and BTB domain containing 44
ZC3H3 zinc finger CCCH-type containing 3
ZIC1 Zic family member 1
ZNF134 zinc finger protein 134
ZNF141 zinc finger protein 141
ZNF442 zinc finger protein 442
ZNF532 zinc finger protein 532
ZNF747 zinc finger protein 747