valproic acid-5211 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the valproic acid-5211 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
AHCYL2 adenosylhomocysteinase-like 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ATF7IP activating transcription factor 7 interacting protein
BLZF1 basic leucine zipper nuclear factor 1
BNC2 basonuclin 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
C7ORF69 chromosome 7 open reading frame 69
CAMK1D calcium/calmodulin-dependent protein kinase ID
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC28B coiled-coil domain containing 28B
CEND1 cell cycle exit and neuronal differentiation 1
CEP112 centrosomal protein 112kDa
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNTNAP2 contactin associated protein-like 2
COL11A2 collagen, type XI, alpha 2
CTIF CBP80/20-dependent translation initiation factor
CUL7 cullin 7
DOK4 docking protein 4
DRD1 dopamine receptor D1
DTX3 deltex 3, E3 ubiquitin ligase
EFNA3 ephrin-A3
EMP3 epithelial membrane protein 3
FBXO41 F-box protein 41
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GJA8 gap junction protein, alpha 8, 50kDa
GLP1R glucagon-like peptide 1 receptor
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
HIST1H1D histone cluster 1, H1d
HMOX1 heme oxygenase 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF5C kinesin family member 5C
KIFC1 kinesin family member C1
LAMC3 laminin, gamma 3
LAMP1 lysosomal-associated membrane protein 1
LHX6 LIM homeobox 6
LIN7A lin-7 homolog A (C. elegans)
LMF2 lipase maturation factor 2
LMNB1 lamin B1
MAL mal, T-cell differentiation protein
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKL1 megakaryoblastic leukemia (translocation) 1
MPL MPL proto-oncogene, thrombopoietin receptor
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NOX1 NADPH oxidase 1
NPM3 nucleophosmin/nucleoplasmin 3
PARD6B par-6 family cell polarity regulator beta
PBX2 pre-B-cell leukemia homeobox 2
PCDHA9 protocadherin alpha 9
PCLO piccolo presynaptic cytomatrix protein
PDLIM5 PDZ and LIM domain 5
PGR progesterone receptor
PICK1 protein interacting with PRKCA 1
PIGR polymeric immunoglobulin receptor
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX2 PBX/knotted 1 homeobox 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POFUT1 protein O-fucosyltransferase 1
PTCRA pre T-cell antigen receptor alpha
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRM protein tyrosine phosphatase, receptor type, M
RAB6A RAB6A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RUSC2 RUN and SH3 domain containing 2
SECTM1 secreted and transmembrane 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SNCG synuclein, gamma (breast cancer-specific protein 1)
SNX13 sorting nexin 13
SORT1 sortilin 1
TBXA2R thromboxane A2 receptor
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TECPR2 tectonin beta-propeller repeat containing 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM63A transmembrane protein 63A
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRPC1 transient receptor potential cation channel, subfamily C, member 1
USP2 ubiquitin specific peptidase 2
WDTC1 WD and tetratricopeptide repeats 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF37BP zinc finger protein 37B, pseudogene
ZNF639 zinc finger protein 639
ZNF821 zinc finger protein 821
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ADCY6 adenylate cyclase 6
AKR1C2 aldo-keto reductase family 1, member C2
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALS2CL ALS2 C-terminal like
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARPIN actin-related protein 2/3 complex inhibitor
ARSB arylsulfatase B
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C11ORF30 chromosome 11 open reading frame 30
C3ORF52 chromosome 3 open reading frame 52
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX4 chromobox homolog 4
CD82 CD82 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDT1 chromatin licensing and DNA replication factor 1
CFD complement factor D (adipsin)
CIR1 corepressor interacting with RBPJ, 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CTDNEP1 CTD nuclear envelope phosphatase 1
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUL9 cullin 9
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DUSP8 dual specificity phosphatase 8
FANCC Fanconi anemia, complementation group C
FBRS fibrosin
GID4 GID complex subunit 4
GUSBP3 glucuronidase, beta pseudogene 3
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H1E histone cluster 1, H1e
HYI hydroxypyruvate isomerase (putative)
IL22 interleukin 22
IL4R interleukin 4 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INCENP inner centromere protein antigens 135/155kDa
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF9 interferon regulatory factor 9
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIF13B kinesin family member 13B
KLF3 Kruppel-like factor 3 (basic)
KLHL26 kelch-like family member 26
KLHL28 kelch-like family member 28
KPTN kaptin (actin binding protein)
KRT13 keratin 13, type I
LAMA3 laminin, alpha 3
LAMP3 lysosomal-associated membrane protein 3
LIG4 ligase IV, DNA, ATP-dependent
LOC100272216 uncharacterized LOC100272216
LZTR1 leucine-zipper-like transcription regulator 1
MAP1S microtubule-associated protein 1S
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MNX1 motor neuron and pancreas homeobox 1
MRPS18C mitochondrial ribosomal protein S18C
N4BP3 NEDD4 binding protein 3
NBEAL2 neurobeachin-like 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PILRB paired immunoglobin-like type 2 receptor beta
PLD3 phospholipase D family, member 3
POMT2 protein-O-mannosyltransferase 2
PRODH proline dehydrogenase (oxidase) 1
QPCTL glutaminyl-peptide cyclotransferase-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RNF31 ring finger protein 31
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
S100A9 S100 calcium binding protein A9
SIX1 SIX homeobox 1
SLIT2 slit homolog 2 (Drosophila)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
TMEM212 transmembrane protein 212
TMPRSS3 transmembrane protease, serine 3
TNS2 tensin 2
TSSC4 tumor suppressing subtransferable candidate 4
UBQLN4 ubiquilin 4
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WBP2 WW domain binding protein 2
ZNF446 zinc finger protein 446
ZNF573 zinc finger protein 573