valproic acid-4446 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the valproic acid-4446 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRL3 adhesion G protein-coupled receptor L3
AIF1 allograft inflammatory factor 1
ARNT aryl hydrocarbon receptor nuclear translocator
ATF5 activating transcription factor 5
ATM ATM serine/threonine kinase
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATXN2L ataxin 2-like
BET1L Bet1 golgi vesicular membrane trafficking protein-like
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CCR9 chemokine (C-C motif) receptor 9
CD52 CD52 molecule
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLSTN3 calsyntenin 3
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
CXXC4 CXXC finger protein 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYTH4 cytohesin 4
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DES desmin
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSC2 desmocollin 2
EDNRA endothelin receptor type A
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPHB2 EPH receptor B2
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC1 exosome component 1
FAM13C family with sequence similarity 13, member C
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FHL5 four and a half LIM domains 5
FRMD8 FERM domain containing 8
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLB1L galactosidase, beta 1-like
GLS glutaminase
GP2 glycoprotein 2 (zymogen granule membrane)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRK5 G protein-coupled receptor kinase 5
HAB1 B1 for mucin
HGFAC HGF activator
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IL1R2 interleukin 1 receptor, type II
INSL4 insulin-like 4 (placenta)
JAK3 Janus kinase 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLHL35 kelch-like family member 35
KLK11 kallikrein-related peptidase 11
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LRRK1 leucine-rich repeat kinase 1
LTB4R leukotriene B4 receptor
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK8 mitogen-activated protein kinase 8
MDFI MyoD family inhibitor
MMP7 matrix metallopeptidase 7
MPZ myelin protein zero
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTMR7 myotubularin related protein 7
MYO15A myosin XVA
NOVA2 neuro-oncological ventral antigen 2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NRF1 nuclear respiratory factor 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ONECUT2 one cut homeobox 2
PCDHGA10 protocadherin gamma subfamily A, 10
PGLYRP1 peptidoglycan recognition protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKP4 plakophilin 4
PLEK pleckstrin
PLXNB2 plexin B2
PODNL1 podocan-like 1
POU5F1B POU class 5 homeobox 1B
PRKCE protein kinase C, epsilon
PSG9 pregnancy specific beta-1-glycoprotein 9
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF2 ring finger protein 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SAFB scaffold attachment factor B
SFRP4 secreted frizzled-related protein 4
SH3BP2 SH3-domain binding protein 2
SIRPA signal-regulatory protein alpha
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SYT5 synaptotagmin V
TMPRSS15 transmembrane protease, serine 15
TP53I11 tumor protein p53 inducible protein 11
TULP2 tubby like protein 2
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZFP64 ZFP64 zinc finger protein
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM23 ADAM metallopeptidase domain 23
AFF4 AF4/FMR2 family, member 4
ALPK1 alpha-kinase 1
ANKH ANKH inorganic pyrophosphate transport regulator
ATAD5 ATPase family, AAA domain containing 5
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP4 bone morphogenetic protein 4
BNC1 basonuclin 1
CAPN15 calpain 15
CCDC186 coiled-coil domain containing 186
CEMIP cell migration inducing protein, hyaluronan binding
CES3 carboxylesterase 3
CIDEC cell death-inducing DFFA-like effector c
CLDN14 claudin 14
CLIC3 chloride intracellular channel 3
COBL cordon-bleu WH2 repeat protein
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CSF1R colony stimulating factor 1 receptor
DNAH7 dynein, axonemal, heavy chain 7
EFNB1 ephrin-B1
EGFL7 EGF-like-domain, multiple 7
EPHA4 EPH receptor A4
ETV6 ets variant 6
EXD3 exonuclease 3'-5' domain containing 3
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF23 fibroblast growth factor 23
FKBP5 FK506 binding protein 5
FRK fyn-related Src family tyrosine kinase
FRMD1 FERM domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HDAC5 histone deacetylase 5
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIST1H2BJ histone cluster 1, H2bj
HIST1H4C histone cluster 1, H4c
HIST2H2AA3 histone cluster 2, H2aa3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IFNA14 interferon, alpha 14
IL22 interleukin 22
INF2 inverted formin, FH2 and WH2 domain containing
IRF2BP1 interferon regulatory factor 2 binding protein 1
KPNA5 karyopherin alpha 5 (importin alpha 6)
LINC00597 long intergenic non-protein coding RNA 597
LMO7 LIM domain 7
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAP6D1 MAP6 domain containing 1
MCTP2 multiple C2 domains, transmembrane 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MN1 meningioma (disrupted in balanced translocation) 1
MSRA methionine sulfoxide reductase A
MT1M metallothionein 1M
MUC3A mucin 3A, cell surface associated
MXRA8 matrix-remodelling associated 8
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKX3-2 NK3 homeobox 2
NOL10 nucleolar protein 10
PADI1 peptidyl arginine deiminase, type I
PAQR5 progestin and adipoQ receptor family member V
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PICK1 protein interacting with PRKCA 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLA1A phospholipase A1 member A
PLSCR2 phospholipid scramblase 2
POMT2 protein-O-mannosyltransferase 2
PRKG2 protein kinase, cGMP-dependent, type II
PTPRH protein tyrosine phosphatase, receptor type, H
PTPRS protein tyrosine phosphatase, receptor type, S
RNF122 ring finger protein 122
S100A3 S100 calcium binding protein A3
SAMD9 sterile alpha motif domain containing 9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCIN scinderin
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMR3A submaxillary gland androgen regulated protein 3A
SPTBN2 spectrin, beta, non-erythrocytic 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TELO2 telomere maintenance 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TMEM177 transmembrane protein 177
TMEM206 transmembrane protein 206
TPCN1 two pore segment channel 1
TRAF2 TNF receptor-associated factor 2
TUBB2B tubulin, beta 2B class IIb
VGF VGF nerve growth factor inducible
WNT16 wingless-type MMTV integration site family, member 16
YY2 YY2 transcription factor
ZNF446 zinc finger protein 446
ZNF639 zinc finger protein 639
ZNF768 zinc finger protein 768