ubiquitin ligase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. (Gene Ontology, GO_0000151)
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Genes

645 proteins co-occuring with the ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDC20 cell division cycle 20 3.16046
SKP1 S-phase kinase-associated protein 1 2.75145
CUL1 cullin 1 2.64097
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.34241
PTTG1 pituitary tumor-transforming 1 2.23752
PARK2 parkin RBR E3 ubiquitin protein ligase 2.11876
CDC27 cell division cycle 27 2.06413
FBXO5 F-box protein 5 2.0503
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.04159
RNF31 ring finger protein 31 1.95512
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 1.85593
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 1.85456
CUL3 cullin 3 1.76626
CAND1 cullin-associated and neddylation-dissociated 1 1.75852
CCNB1 cyclin B1 1.73184
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.72557
ANAPC11 anaphase promoting complex subunit 11 1.71373
CDC16 cell division cycle 16 1.67568
FBXO43 F-box protein 43 1.64075
ANAPC5 anaphase promoting complex subunit 5 1.63896
CUL2 cullin 2 1.63539
CDC23 cell division cycle 23 1.63301
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 1.60651
SHARPIN SHANK-associated RH domain interactor 1.58795
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.58795
CDC34 cell division cycle 34 1.57531
UBE2S ubiquitin-conjugating enzyme E2S 1.57474
UBE2H ubiquitin-conjugating enzyme E2H 1.54404
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 1.54235
CDK1 cyclin-dependent kinase 1 1.54009
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 1.52371
BUB3 BUB3 mitotic checkpoint protein 1.51017
ANAPC10 anaphase promoting complex subunit 10 1.47627
CUL5 cullin 5 1.44347
PLK1 polo-like kinase 1 1.42542
ANAPC4 anaphase promoting complex subunit 4 1.38405
RNF4 ring finger protein 4 1.37243
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 1.36252
DDB1 damage-specific DNA binding protein 1, 127kDa 1.35156
CUL4B cullin 4B 1.34992
CUL4A cullin 4A 1.34938
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.33413
UBE2K ubiquitin-conjugating enzyme E2K 1.32546
CUL7 cullin 7 1.23192
CDK2 cyclin-dependent kinase 2 1.20705
BARD1 BRCA1 associated RING domain 1 1.18851
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 1.18697
UBE2M ubiquitin-conjugating enzyme E2M 1.1603
CDC14A cell division cycle 14A 1.13932
GMNN geminin, DNA replication inhibitor 1.13063
UBE2D2 ubiquitin-conjugating enzyme E2D 2 1.13012
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.12041
UBA3 ubiquitin-like modifier activating enzyme 3 1.11837
FBXW8 F-box and WD repeat domain containing 8 1.11021
CDT1 chromatin licensing and DNA replication factor 1 1.09086
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.07714
BCR breakpoint cluster region 1.07359
WEE1 WEE1 G2 checkpoint kinase 1.04683
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 1.03879
RARA retinoic acid receptor, alpha 1.00497
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 1.00399
CDC26 cell division cycle 26 0.991225
GLMN glomulin, FKBP associated protein 0.960227
CCNF cyclin F 0.95305
ANAPC13 anaphase promoting complex subunit 13 0.944956
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.933601
COPS5 COP9 signalosome subunit 5 0.933601
UBE2C ubiquitin-conjugating enzyme E2C 0.923728
FBXO45 F-box protein 45 0.891169
OTULIN OTU deubiquitinase with linear linkage specificity 0.888397
SPOP speckle-type POZ protein 0.868586
USP44 ubiquitin specific peptidase 44 0.852961
FLT3 fms-related tyrosine kinase 3 0.84791
AURKB aurora kinase B 0.83781
CDC6 cell division cycle 6 0.825418
CDCA3 cell division cycle associated 3 0.81257
CUEDC2 CUE domain containing 2 0.810735
RNF7 ring finger protein 7 0.802021
FBXO2 F-box protein 2 0.800645
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.800187
FBXO27 F-box protein 27 0.789191
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.787359
BRCA1 breast cancer 1, early onset 0.777755
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.774101
KEAP1 kelch-like ECH-associated protein 1 0.773188
NAE1 NEDD8 activating enzyme E1 subunit 1 0.764982
FBXO6 F-box protein 6 0.763617
ERLEC1 endoplasmic reticulum lectin 1 0.754983
KLHL3 kelch-like family member 3 0.750904
FBXL3 F-box and leucine-rich repeat protein 3 0.749999
ASB4 ankyrin repeat and SOCS box containing 4 0.747737
KCTD21 potassium channel tetramerization domain containing 21 0.747737
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.737363
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.734666
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.727047
OR5I1 olfactory receptor, family 5, subfamily I, member 1 0.726599
CDC20B cell division cycle 20B 0.726599
ANAPC2 anaphase promoting complex subunit 2 0.725258
UBE2F ubiquitin-conjugating enzyme E2F (putative) 0.723026
CDC25A cell division cycle 25A 0.720351
TP53 tumor protein p53 0.702185
MAGEA6 melanoma antigen family A6 0.701304
KLHL40 kelch-like family member 40 0.701304
FBXW2 F-box and WD repeat domain containing 2 0.690326
EVI5 ecotropic viral integration site 5 0.687701
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.683771
CHEK1 checkpoint kinase 1 0.67463
ANAPC7 anaphase promoting complex subunit 7 0.672894
DEPTOR DEP domain containing MTOR-interacting protein 0.671159
UBE2N ubiquitin-conjugating enzyme E2N 0.665962
FBXO25 F-box protein 25 0.661208
ANAPC16 anaphase promoting complex subunit 16 0.655172
TRIM25 tripartite motif containing 25 0.651299
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 0.647862
LRRC41 leucine rich repeat containing 41 0.645716
NEURL2 neuralized E3 ubiquitin protein ligase 2 0.644858
UBA1 ubiquitin-like modifier activating enzyme 1 0.642286
TRIM39-RPP21 TRIM39-RPP21 readthrough 0.641001
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.639289
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 0.638434
SUMO3 small ubiquitin-like modifier 3 0.63715
FBXL5 F-box and leucine-rich repeat protein 5 0.635868
PLK2 polo-like kinase 2 0.63544
UBD ubiquitin D 0.632024
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 0.631171
SGOL1 shugoshin-like 1 (S. pombe) 0.626909
GZMM granzyme M (lymphocyte met-ase 1) 0.620529
SUMO2 small ubiquitin-like modifier 2 0.61968
UBXN7 UBX domain protein 7 0.615013
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.613742
FBXO11 F-box protein 11 0.607818
UBE3A ubiquitin protein ligase E3A 0.603596
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.602752
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.602331
FBXL2 F-box and leucine-rich repeat protein 2 0.597697
CENPE centromere protein E, 312kDa 0.597276
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.597276
FBXW4 F-box and WD repeat domain containing 4 0.596435
FBXO22 F-box protein 22 0.596435
KLHL10 kelch-like family member 10 0.590133
KLHL2 kelch-like family member 2 0.588037
TRIM39 tripartite motif containing 39 0.587618
USP37 ubiquitin specific peptidase 37 0.576747
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.572994
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.572578
VPRBP Vpr (HIV-1) binding protein 0.571329
RNF111 ring finger protein 111 0.569248
FBXL12 F-box and leucine-rich repeat protein 12 0.567585
CDC25C cell division cycle 25C 0.563432
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.561772
UBE2A ubiquitin-conjugating enzyme E2A 0.558042
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.556387
CDCA5 cell division cycle associated 5 0.554732
UBE2I ubiquitin-conjugating enzyme E2I 0.552664
FBXW5 F-box and WD repeat domain containing 5 0.552251
FBXL16 F-box and leucine-rich repeat protein 16 0.547297
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.539472
FBXO9 F-box protein 9 0.536183
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.536183
KLHL20 kelch-like family member 20 0.533719
XPC xeroderma pigmentosum, complementation group C 0.52716
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.526341
USP15 ubiquitin specific peptidase 15 0.523067
FBXO18 F-box protein, helicase, 18 0.520615
RAE1 ribonucleic acid export 1 0.520206
UBE2T ubiquitin-conjugating enzyme E2T 0.516532
EGLN2 egl-9 family hypoxia-inducible factor 2 0.515308
CCNE1 cyclin E1 0.514085
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.510826
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.503099
NUSAP1 nucleolar and spindle associated protein 1 0.50107
UIMC1 ubiquitin interaction motif containing 1 0.500258
COMMD1 copper metabolism (Murr1) domain containing 1 0.498636
KLHL12 kelch-like family member 12 0.49499
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.490135
RAD18 RAD18 E3 ubiquitin protein ligase 0.486904
FBXW9 F-box and WD repeat domain containing 9 0.486096
ZC3HC1 zinc finger, C3HC-type containing 1 0.485693
TBCE tubulin folding cofactor E 0.485693
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.484886
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.482467
KLHL11 kelch-like family member 11 0.47844
SARAF store-operated calcium entry-associated regulatory factor 0.475223
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.473617
CKAP2L cytoskeleton associated protein 2-like 0.470005
CASC1 cancer susceptibility candidate 1 0.463997
CDC25B cell division cycle 25B 0.458006
KCTD6 potassium channel tetramerization domain containing 6 0.455613
FBXO4 F-box protein 4 0.454019
FBXL14 F-box and leucine-rich repeat protein 14 0.452825
CYLD cylindromatosis (turban tumor syndrome) 0.452427
RNF165 ring finger protein 165 0.447656
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 0.447656
ANK1 ankyrin 1, erythrocytic 0.445672
EGLN1 egl-9 family hypoxia-inducible factor 1 0.439728
CRBN cereblon 0.439333
USP33 ubiquitin specific peptidase 33 0.438146
CCAR1 cell division cycle and apoptosis regulator 1 0.432618
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 0.431435
RNF6 ring finger protein (C3H2C3 type) 6 0.430647
MAD2L1BP MAD2L1 binding protein 0.425924
RNF169 ring finger protein 169 0.412601
RNF123 ring finger protein 123 0.412601
TRIP13 thyroid hormone receptor interactor 13 0.41182
RAB9B RAB9B, member RAS oncogene family 0.408309
NUP98 nucleoporin 98kDa 0.402859
MDC1 mediator of DNA-damage checkpoint 1 0.399751
SAT2 spermidine/spermine N1-acetyltransferase family member 2 0.392388
C18ORF25 chromosome 18 open reading frame 25 0.391228
EGLN3 egl-9 family hypoxia-inducible factor 3 0.390841
NOTCH1 notch 1 0.390841
RHOBTB2 Rho-related BTB domain containing 2 0.387751
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.386208
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.381199
ANAPC1 anaphase promoting complex subunit 1 0.380045
TMEM189 transmembrane protein 189 0.379276
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.377354
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 0.375818
CCND1 cyclin D1 0.375818
SPOPL speckle-type POZ protein-like 0.374283
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.372749
MORF4L2 mortality factor 4 like 2 0.363185
ATM ATM serine/threonine kinase 0.362422
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.356705
KCTD11 potassium channel tetramerization domain containing 11 0.354802
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.354042
DUSP1 dual specificity phosphatase 1 0.350622
TK1 thymidine kinase 1, soluble 0.347967
RING1 ring finger protein 1 0.34645
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.345692
TMUB1 transmembrane and ubiquitin-like domain containing 1 0.344178
SPRTN SprT-like N-terminal domain 0.343799
CCNA2 cyclin A2 0.343421
MIIP migration and invasion inhibitory protein 0.341529
SPATC1 spermatogenesis and centriole associated 1 0.332472
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.330966
TAL2 T-cell acute lymphocytic leukemia 2 0.330589
DDB2 damage-specific DNA binding protein 2, 48kDa 0.329084
DGKI diacylglycerol kinase, iota 0.326078
KLHL7 kelch-like family member 7 0.323825
TRIM69 tripartite motif containing 69 0.3227
ORC6 origin recognition complex, subunit 6 0.321575
HOXC10 homeobox C10 0.321575
FBXO32 F-box protein 32 0.321201
USP12 ubiquitin specific peptidase 12 0.320451
CISH cytokine inducible SH2-containing protein 0.320451
RIPK2 receptor-interacting serine-threonine kinase 2 0.319328
KDM4A lysine (K)-specific demethylase 4A 0.319328
LRR1 leucine rich repeat protein 1 0.318579
RFWD3 ring finger and WD repeat domain 3 0.318205
HOXC5 homeobox C5 0.312971
DSN1 DSN1, MIS12 kinetochore complex component 0.312971
NUB1 negative regulator of ubiquitin-like proteins 1 0.309613
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.309613
KLHL22 kelch-like family member 22 0.30924
HINT1 histidine triad nucleotide binding protein 1 0.306632
TPR translocated promoter region, nuclear basket protein 0.304771
PML promyelocytic leukemia 0.303655
TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 0.30254
FAM64A family with sequence similarity 64, member A 0.302168
FER fer (fps/fes related) tyrosine kinase 0.301054
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.29623
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.29586
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.291787
POLH polymerase (DNA directed), eta 0.290678
MRFAP1 Morf4 family associated protein 1 0.290678
MYH11 myosin, heavy chain 11, smooth muscle 0.290308
ASB9 ankyrin repeat and SOCS box containing 9 0.289569
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.289199
RNF135 ring finger protein 135 0.287352
RTN4RL1 reticulon 4 receptor-like 1 0.286245
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.284769
BRWD1 bromodomain and WD repeat domain containing 1 0.279245
RNF25 ring finger protein 25 0.278877
FBXL15 F-box and leucine-rich repeat protein 15 0.278141
FBXL4 F-box and leucine-rich repeat protein 4 0.276304
MASTL microtubule associated serine/threonine kinase-like 0.276304
CAPRIN2 caprin family member 2 0.273734
USP47 ubiquitin specific peptidase 47 0.271533
TRRAP transformation/transcription domain-associated protein 0.268603
UBE3C ubiquitin protein ligase E3C 0.268237
NKX6-1 NK6 homeobox 1 0.267505
SMAD3 SMAD family member 3 0.265311
GRWD1 glutamate-rich WD repeat containing 1 0.264215
MINK1 misshapen-like kinase 1 0.260566
RHOBTB3 Rho-related BTB domain containing 3 0.260202
AURKA aurora kinase A 0.259109
DERL1 derlin 1 0.258016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.256561
AXIN1 axin 1 0.253653
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.251114
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.250026
ATR ATR serine/threonine kinase 0.249302
KIF18A kinesin family member 18A 0.247854
RHOBTB1 Rho-related BTB domain containing 1 0.247492
CD33 CD33 molecule 0.24713
USP39 ubiquitin specific peptidase 39 0.246046
RTN4RL2 reticulon 4 receptor-like 2 0.245685
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.243879
MIS12 MIS12 kinetochore complex component 0.243519
UBE2D1 ubiquitin-conjugating enzyme E2D 1 0.239197
COPS3 COP9 signalosome subunit 3 0.237042
FANCD2 Fanconi anemia, complementation group D2 0.237042
STAT2 signal transducer and activator of transcription 2, 113kDa 0.235249
CENPA centromere protein A 0.234533
PLK4 polo-like kinase 4 0.233817
USP1 ubiquitin specific peptidase 1 0.233101
CCNY cyclin Y 0.232386
CKS1B CDC28 protein kinase regulatory subunit 1B 0.232029
RAD21 RAD21 homolog (S. pombe) 0.231672
CRY2 cryptochrome circadian clock 2 0.230245
CD34 CD34 molecule 0.229888
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.223143
PLCZ1 phospholipase C, zeta 1 0.22173
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 0.221025
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.220673
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.218914
M6PR mannose-6-phosphate receptor (cation dependent) 0.217511
MOAP1 modulator of apoptosis 1 0.216111
BIRC6 baculoviral IAP repeat containing 6 0.215063
PCNA proliferating cell nuclear antigen 0.214714
MPEG1 macrophage expressed 1 0.214366
BRSK2 BR serine/threonine kinase 2 0.213322
DBF4 DBF4 zinc finger 0.211933
CDK4 cyclin-dependent kinase 4 0.21124
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.209513
MAK male germ cell-associated kinase 0.209169
MALT1 MALT1 paracaspase 0.207451
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.207108
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 0.205059
BIRC2 baculoviral IAP repeat containing 2 0.202684
WEE2 WEE1 homolog 2 (S. pombe) 0.202684
PRCC papillary renal cell carcinoma (translocation-associated) 0.202346
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.201672
METAP2 methionyl aminopeptidase 2 0.200999
KLF5 Kruppel-like factor 5 (intestinal) 0.196339
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.19601
IP6K1 inositol hexakisphosphate kinase 1 0.194045
SMAD2 SMAD family member 2 0.190495
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.189539
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.18859
DERL3 derlin 3 0.188274
SAMHD1 SAM domain and HD domain 1 0.188274
CDK14 cyclin-dependent kinase 14 0.18796
CCNO cyclin O 0.18796
PHF20 PHD finger protein 20 0.18796
FBXO3 F-box protein 3 0.18702
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.184853
E2F7 E2F transcription factor 7 0.184241
PDLIM2 PDZ and LIM domain 2 (mystique) 0.183631
FBXO24 F-box protein 24 0.182122
TOB2 transducer of ERBB2, 2 0.180634
DCPS decapping enzyme, scavenger 0.180045
TUBGCP3 tubulin, gamma complex associated protein 3 0.178877
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.178877
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.174635
INVS inversin 0.174087
EPT1 ethanolaminephosphotransferase 1 0.173543
PDCD2 programmed cell death 2 0.173543
MCM2 minichromosome maintenance complex component 2 0.171673
RTN4R reticulon 4 receptor 0.170371
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.169604
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.166884
PFDN5 prefoldin subunit 5 0.165697
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.165231
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.164089
EIF3M eukaryotic translation initiation factor 3, subunit M 0.162117
AURKAIP1 aurora kinase A interacting protein 1 0.161905
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.161693
KIFC1 kinesin family member C1 0.161275
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.159462
DDIT4 DNA-damage-inducible transcript 4 0.159268
CKAP2 cytoskeleton associated protein 2 0.159074
CDC5L cell division cycle 5-like 0.158315
HSF2 heat shock transcription factor 2 0.157397
GLI1 GLI family zinc finger 1 0.156688
NEUROD2 neuronal differentiation 2 0.156513
FAXDC2 fatty acid hydroxylase domain containing 2 0.156513
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.134753
STC1 stanniocalcin 1 0.129457
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.12694
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.125698
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.120543
CBX4 chromobox homolog 4 0.120324
PRC1 protein regulator of cytokinesis 1 0.119279
DIRC2 disrupted in renal carcinoma 2 0.118864
HSPA4 heat shock 70kDa protein 4 0.118168
KITLG KIT ligand 0.116208
BMI1 BMI1 proto-oncogene, polycomb ring finger 0.111814
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.111582
KDM2B lysine (K)-specific demethylase 2B 0.110816
CMA1 chymase 1, mast cell 0.109296
CBX7 chromobox homolog 7 0.108873
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.10597
CBX8 chromobox homolog 8 0.105018
ERCC5 excision repair cross-complementation group 5 0.104517
SENP6 SUMO1/sentrin specific peptidase 6 0.102951
ERCC2 excision repair cross-complementation group 2 0.102406
CBX2 chromobox homolog 2 0.101998
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.101941
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase 0.101873
SCML2 sex comb on midleg-like 2 (Drosophila) 0.101827
ERCC4 excision repair cross-complementation group 4 0.101725
DCX doublecortin 0.101623
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.101473
MCPH1 microcephalin 1 0.10138
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.101334
PHF8 PHD finger protein 8 0.101229
RNF2 ring finger protein 2 0.101055
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.10102
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.100776
HOXD10 homeobox D10 0.100278
FAN1 FANCD2/FANCI-associated nuclease 1 0.100029
METTL13 methyltransferase like 13 0.099922
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.09968
GLS glutaminase 0.099607
HELZ helicase with zinc finger 0.099595
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.099317
ASXL1 additional sex combs like transcriptional regulator 1 0.099159
H2AFJ H2A histone family, member J 0.098777
HIST1H2AJ histone cluster 1, H2aj 0.098777
HIST1H2AM histone cluster 1, H2am 0.098777
HIST1H2AD histone cluster 1, H2ad 0.098777
HIST1H2AH histone cluster 1, H2ah 0.098765
HIST1H2AG histone cluster 1, H2ag 0.098728
H2AFY2 H2A histone family, member Y2 0.098678
HIST1H2AE histone cluster 1, H2ae 0.098653
HIST1H2AB histone cluster 1, H2ab 0.098653
H2AFV H2A histone family, member V 0.098641
H2AFB1 H2A histone family, member B1 0.098555
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.09853
IL17RC interleukin 17 receptor C 0.09853
H2AFB2 H2A histone family, member B2 0.098443
H2AFY H2A histone family, member Y 0.098332
PCGF2 polycomb group ring finger 2 0.098258
LUZP6 leucine zipper protein 6 0.098119
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 0.098056
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.097981
CLTA clathrin, light chain A 0.097779
VCP valosin containing protein 0.097703
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.097628
CCL15 chemokine (C-C motif) ligand 15 0.097615
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.097363
GTSE1 G-2 and S-phase expressed 1 0.097324
CCNB2 cyclin B2 0.097311
SMC3 structural maintenance of chromosomes 3 0.097208
L3MBTL2 l(3)mbt-like 2 (Drosophila) 0.096553
CBX6 chromobox homolog 6 0.095597
XPA xeroderma pigmentosum, complementation group A 0.095304
MCM7 minichromosome maintenance complex component 7 0.095157
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.094703
RUNX1 runt-related transcription factor 1 0.094608
H2AFX H2A histone family, member X 0.093199
BCOR BCL6 corepressor 0.092977
FBXO44 F-box protein 44 0.092291
CNOT1 CCR4-NOT transcription complex, subunit 1 0.092249
HIST2H2AC histone cluster 2, H2ac 0.091769
HIST2H2AA3 histone cluster 2, H2aa3 0.091755
HIST2H2AA4 histone cluster 2, H2aa4 0.091755
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.091368
TCEA1 transcription elongation factor A (SII), 1 0.09124
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 0.09065
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.089981
IRS1 insulin receptor substrate 1 0.089584
RYBP RING1 and YY1 binding protein 0.089555
SOCS5 suppressor of cytokine signaling 5 0.089363
PCGF1 polycomb group ring finger 1 0.088051
MTF2 metal response element binding transcription factor 2 0.087461
E2F6 E2F transcription factor 6 0.087202
TRIM24 tripartite motif containing 24 0.087111
MUS81 MUS81 structure-specific endonuclease subunit 0.084663
SH2D1A SH2 domain containing 1A 0.084188
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.083887
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.083538
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.083313
H3F3A H3 histone, family 3A 0.083169
H3F3B H3 histone, family 3B (H3.3B) 0.083169
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.082671
PCGF6 polycomb group ring finger 6 0.082268
KIF20B kinesin family member 20B 0.081586
PHC1 polyhomeotic homolog 1 (Drosophila) 0.08157
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.081554
TACC3 transforming, acidic coiled-coil containing protein 3 0.081554
TDP1 tyrosyl-DNA phosphodiesterase 1 0.081521
NOD2 nucleotide-binding oligomerization domain containing 2 0.081505
TUBA1A tubulin, alpha 1a 0.08144
CCNA1 cyclin A1 0.081343
EPAS1 endothelial PAS domain protein 1 0.081211
YAF2 YY1 associated factor 2 0.081129
NINL ninein-like 0.080965
PIAS2 protein inhibitor of activated STAT, 2 0.080899
CARD11 caspase recruitment domain family, member 11 0.080751
FOXG1 forkhead box G1 0.080587
NCAM1 neural cell adhesion molecule 1 0.080439
LATS2 large tumor suppressor kinase 2 0.080242
NMRAL1 NmrA-like family domain containing 1 0.08021
VIM vimentin 0.080093
CDKN2A cyclin-dependent kinase inhibitor 2A 0.079844
CDX2 caudal type homeobox 2 0.079412
IGLV7-43 immunoglobulin lambda variable 7-43 0.079412
PHC3 polyhomeotic homolog 3 (Drosophila) 0.07913
NPHP3 nephronophthisis 3 (adolescent) 0.07898
ZFP42 ZFP42 zinc finger protein 0.078879
TNF tumor necrosis factor 0.078779
SLC39A2 solute carrier family 39 (zinc transporter), member 2 0.078477
PIAS4 protein inhibitor of activated STAT, 4 0.078393
PHC2 polyhomeotic homolog 2 (Drosophila) 0.078225
KIF4A kinesin family member 4A 0.078208
SKA3 spindle and kinetochore associated complex subunit 3 0.077873
LOXL1 lysyl oxidase-like 1 0.077856
MAST4 microtubule associated serine/threonine kinase family member 4 0.077839
USP11 ubiquitin specific peptidase 11 0.077703
DOT1L DOT1-like histone H3K79 methyltransferase 0.077466
RELN reelin 0.077466
SENP1 SUMO1/sentrin specific peptidase 1 0.077415
CRYBB2 crystallin, beta B2 0.077246
EPN1 epsin 1 0.077229
BCL10 B-cell CLL/lymphoma 10 0.077212
PGM3 phosphoglucomutase 3 0.077077
CENPH centromere protein H 0.076992
PRMT8 protein arginine methyltransferase 8 0.076975
CYCS cytochrome c, somatic 0.076891
ZW10 zw10 kinetochore protein 0.076789
PIAS1 protein inhibitor of activated STAT, 1 0.076755
NDC80 NDC80 kinetochore complex component 0.076619
BRD7 bromodomain containing 7 0.076379
LINGO1 leucine rich repeat and Ig domain containing 1 0.076294
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.075918
RAD52 RAD52 homolog (S. cerevisiae) 0.075559
HSPA1B heat shock 70kDa protein 1B 0.074663
RUVBL2 RuvB-like AAA ATPase 2 0.074577
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.074526
BRCA2 breast cancer 2, early onset 0.073884
IGF2 insulin-like growth factor 2 0.073797
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.073467
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.07319
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.073015
PHF19 PHD finger protein 19 0.072997
EED embryonic ectoderm development 0.072962
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.072787
DLL1 delta-like 1 (Drosophila) 0.072752
CD7 CD7 molecule 0.072455
ISG15 ISG15 ubiquitin-like modifier 0.072437
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.072298
CD19 CD19 molecule 0.071948
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.071895
MOV10 Mov10 RISC complex RNA helicase 0.07186
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.071842
TRIM9 tripartite motif containing 9 0.071736
FLNA filamin A, alpha 0.071648
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.071261
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.070962
CANX calnexin 0.070944
TOB1 transducer of ERBB2, 1 0.070909
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.070804
SFMBT1 Scm-like with four mbt domains 1 0.070467
NLK nemo-like kinase 0.070325
KIF14 kinesin family member 14 0.069847
PDCL3 phosducin-like 3 0.069724
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.069368
HSPA1A heat shock 70kDa protein 1A 0.068959
FBXO28 F-box protein 28 0.068941
CD9 CD9 molecule 0.068407
DEK DEK proto-oncogene 0.06839
SYP synaptophysin 0.067728
CHMP2A charged multivesicular body protein 2A 0.067567
ASCL2 achaete-scute family bHLH transcription factor 2 0.067335
WT1 Wilms tumor 1 0.067084
TAL1 T-cell acute lymphocytic leukemia 1 0.067048
MECOM MDS1 and EVI1 complex locus 0.06703
BRAP BRCA1 associated protein 0.066904
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.066761
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.066725
CLOCK clock circadian regulator 0.066617
KLF10 Kruppel-like factor 10 0.066563
PARVB parvin, beta 0.066455
HMBS hydroxymethylbilane synthase 0.066455
TWIST1 twist family bHLH transcription factor 1 0.066438
HOXC13 homeobox C13 0.066222
ASRGL1 asparaginase like 1 0.066079
MMP8 matrix metallopeptidase 8 0.065287
FBXO17 F-box protein 17 0.065124
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.06498
CREB1 cAMP responsive element binding protein 1 0.06498
CCND3 cyclin D3 0.064854
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.064692
UBC ubiquitin C 0.064548
ING3 inhibitor of growth family, member 3 0.064476
WNT1 wingless-type MMTV integration site family, member 1 0.064421
CIRBP cold inducible RNA binding protein 0.064186
PDGFB platelet-derived growth factor beta polypeptide 0.064168
BTG2 BTG family, member 2 0.063789
CLIP1 CAP-GLY domain containing linker protein 1 0.063771
BTK Bruton agammaglobulinemia tyrosine kinase 0.063771
RPS27A ribosomal protein S27a 0.063446
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.063301
GPI glucose-6-phosphate isomerase 0.063156
KMT2A lysine (K)-specific methyltransferase 2A 0.063156
NANOG Nanog homeobox 0.063084
JARID2 jumonji, AT rich interactive domain 2 0.062975
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.062957
UBB ubiquitin B 0.06274
HIPK2 homeodomain interacting protein kinase 2 0.06265
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.062541
STRA8 stimulated by retinoic acid 8 0.062541
NOD1 nucleotide-binding oligomerization domain containing 1 0.062487
SETD7 SET domain containing (lysine methyltransferase) 7 0.062378
COX5A cytochrome c oxidase subunit Va 0.062306
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.062161
KDM6A lysine (K)-specific demethylase 6A 0.06178
SRSF2 serine/arginine-rich splicing factor 2 0.061762
RAG1 recombination activating gene 1 0.061581
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.061345
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.061146
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.061037
KLF4 Kruppel-like factor 4 (gut) 0.060856
SMAD9 SMAD family member 9 0.060711
MAVS mitochondrial antiviral signaling protein 0.060656
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.060602
HLA-G major histocompatibility complex, class I, G 0.060402
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.060384
YY1 YY1 transcription factor 0.060312
ACHE acetylcholinesterase (Yt blood group) 0.060312
INSR insulin receptor 0.059967
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.059786
PCDH8 protocadherin 8 0.059768
HDAC7 histone deacetylase 7 0.059659
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.059586
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.059514
TRAF3 TNF receptor-associated factor 3 0.059477
CRY1 cryptochrome circadian clock 1 0.059441
SAE1 SUMO1 activating enzyme subunit 1 0.05926
MNX1 motor neuron and pancreas homeobox 1 0.059223
MYB v-myb avian myeloblastosis viral oncogene homolog 0.058679
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.058661
PHGDH phosphoglycerate dehydrogenase 0.058516
PRMT2 protein arginine methyltransferase 2 0.058444
HCFC1 host cell factor C1 0.058371
KMT2B lysine (K)-specific methyltransferase 2B 0.058298
UBE2B ubiquitin-conjugating enzyme E2B 0.057936
ACE angiotensin I converting enzyme 0.057791
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.057772
YAP1 Yes-associated protein 1 0.057519
EYA1 EYA transcriptional coactivator and phosphatase 1 0.05741
NEK2 NIMA-related kinase 2 0.05741