type ii diabetes mellitus Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.|A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity. (Experimental Factor Ontology, EFO_0001360)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa04930.html
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Genes

42 proteins participating in the type ii diabetes mellitus pathway from the KEGG Pathways dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ADIPOQ adiponectin, C1Q and collagen domain containing
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
GCK glucokinase (hexokinase 4)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
PDX1 pancreatic and duodenal homeobox 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKLR pyruvate kinase, liver and RBC
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
TNF tumor necrosis factor