type i diabetes mellitus Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.|Diabetes mellitus characterized by insulin deficiency, sudden onset, severe hyperglycemia, rapid progression to ketoacidosis, and death unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.|An autoimmune disease of endocrine system and is_a diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas. (Experimental Factor Ontology, EFO_0001359)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa04940.html
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Genes

44 proteins participating in the type i diabetes mellitus pathway from the KEGG Pathways dataset.

Symbol Name
CD28 CD28 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CPE carboxypeptidase E
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICA1 islet cell autoantigen 1, 69kDa
IFNG interferon, gamma
IL12A interleukin 12A
IL12B interleukin 12B
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
INS insulin
LTA lymphotoxin alpha
PRF1 perforin 1 (pore forming protein)
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
TNF tumor necrosis factor