type 2 diabetes Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group metabolic (Genetic Association Database)
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Genes

359 genes associated with the disease type 2 diabetes in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACAA2 acetyl-CoA acyltransferase 2
ACACB acetyl-CoA carboxylase beta
ACAD10 acyl-CoA dehydrogenase family, member 10
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACSS2 acyl-CoA synthetase short-chain family member 2
ADAM30 ADAM metallopeptidase domain 30
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY5 adenylate cyclase 5
ADD1 adducin 1 (alpha)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHI1 Abelson helper integration site 1
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANGPTL3 angiopoietin-like 3
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLN apelin
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOC4 apolipoprotein C-IV
APOE apolipoprotein E
AQP2 aquaporin 2 (collecting duct)
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG9B autophagy related 9B
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL7B B-cell CLL/lymphoma 7B
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BUD13 BUD13 homolog (S. cerevisiae)
C1ORF110 chromosome 1 open reading frame 110
C1ORF167 chromosome 1 open reading frame 167
C2CD4A C2 calcium-dependent domain containing 4A
C2CD4B C2 calcium-dependent domain containing 4B
C5 complement component 5
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAMTA1 calmodulin binding transcription activator 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPN10 calpain 10
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CAT catalase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC123 cell division cycle 123
CDCA3 cell division cycle associated 3
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CETP cholesteryl ester transfer protein, plasma
CHN2 chimerin 2
CLCC1 chloride channel CLIC-like 1
CLCN6 chloride channel, voltage-sensitive 6
COX1
CPVL carboxypeptidase, vitellogenic-like
CRP C-reactive protein, pentraxin-related
CRTC2 CREB regulated transcription coactivator 2
CRY2 cryptochrome circadian clock 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCD dermcidin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DGKB diacylglycerol kinase, beta 90kDa
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DUSP9 dual specificity phosphatase 9
EDN1 endothelin 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ETV5 ets variant 5
EXT2 exostosin glycosyltransferase 2
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FABP1 fatty acid binding protein 1, liver
FABP2 fatty acid binding protein 2, intestinal
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF2 fibroblast growth factor 2 (basic)
FRMD3 FERM domain containing 3
FTO fat mass and obesity associated
G6PC2 glucose-6-phosphatase, catalytic, 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GC group-specific component (vitamin D binding protein)
GCG glucagon
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHRL ghrelin/obestatin prepropeptide
GIP gastric inhibitory polypeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GREM1 gremlin 1, DAN family BMP antagonist
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAVCR1 hepatitis A virus cellular receptor 1
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA1 high mobility group AT-hook 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL13 interleukin 13
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
INS insulin
INSIG1 insulin induced gene 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB6 integrin, beta 6
JAZF1 JAZF zinc finger 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCTD12 potassium channel tetramerization domain containing 12
KCTD15 potassium channel tetramerization domain containing 15
KIF11 kinesin family member 11
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF15 Kruppel-like factor 15
KLF16 Kruppel-like factor 16
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LEPROT leptin receptor overlapping transcript
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LINC00271 long intergenic non-protein coding RNA 271
LIPC lipase, hepatic
LIPG lipase, endothelial
LMNA lamin A/C
LPIN2 lipin 2
LPL lipoprotein lipase
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
MADD MAP-kinase activating death domain
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MBL2 mannose-binding lectin (protein C) 2, soluble
MC4R melanocortin 4 receptor
MCF2L2 MCF.2 cell line derived transforming sequence-like 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLXIPL MLX interacting protein-like
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MMP2 matrix metallopeptidase 2
MMP26 matrix metallopeptidase 26
MMP3 matrix metallopeptidase 3
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MT-ND3 NADH dehydrogenase, subunit 3 (complex I)
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-TK tRNA
MT-TQ tRNA
MT-TR tRNA
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
MVK mevalonate kinase
MYH9 myosin, heavy chain 9, non-muscle
NAMPT nicotinamide phosphoribosyltransferase
ND1
NEGR1 neuronal growth regulator 1
NEUROG3 neurogenin 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRC5 NLR family, CARD domain containing 5
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH2 notch 2
NPC1 Niemann-Pick disease, type C1
NPPA natriuretic peptide A
NPY neuropeptide Y
NRF1 nuclear respiratory factor 1
OGG1 8-oxoguanine DNA glycosylase
PBX1 pre-B-cell leukemia homeobox 1
PBX2 pre-B-cell leukemia homeobox 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDX1 pancreatic and duodenal homeobox 1
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKLR pyruvate kinase, liver and RBC
PKN2 protein kinase N2
PLTP phospholipid transfer protein
PON1 paraoxonase 1
PON2 paraoxonase 2
POU2F1 POU class 2 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PROX1 prospero homeobox 1
PTER phosphotriesterase related
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRS protein tyrosine phosphatase, receptor type, S
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASAL2 RAS protein activator like 2
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP4 retinol binding protein 4, plasma
RETN resistin
RHOA ras homolog family member A
RHOQ ras homolog family member Q
RXRG retinoid X receptor, gamma
SARS seryl-tRNA synthetase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC16B SEC16 homolog B (S. cerevisiae)
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B1 SH2B adaptor protein 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC35G5 solute carrier family 35, member G5
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMAD6 SMAD family member 6
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SNAP23 synaptosomal-associated protein, 23kDa
SNTG1 syntrophin, gamma 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
SRR serine racemase
STK11 serine/threonine kinase 11
STK32C serine/threonine kinase 32C
STK33 serine/threonine kinase 33
STRA13 stimulated by retinoic acid 13
STRA6 stimulated by retinoic acid 6
STXBP3 syntaxin binding protein 3
STXBP4 syntaxin binding protein 4
SUMO4 small ubiquitin-like modifier 4
SYN2 synapsin II
TBL2 transducin (beta)-like 2
TCF20 transcription factor 20 (AR1)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFB1M transcription factor B1, mitochondrial
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THADA thyroid adenoma associated
TLR4 toll-like receptor 4
TMEM18 transmembrane protein 18
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRIB1 tribbles pseudokinase 1
TRNE
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
TSPAN9 tetraspanin 9
TTC39B tetratricopeptide repeat domain 39B
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UTS2 urotensin 2
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP3 vesicle-associated membrane protein 3
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WFS1 Wolfram syndrome 1 (wolframin)