type 2 diabetes mellitus Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly. (Human Disease Ontology, DOID_9352)
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Genes

273 genes associated with the disease type 2 diabetes mellitus in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
G6PC2 glucose-6-phosphatase, catalytic, 2 2.92288
MADD MAP-kinase activating death domain 2.47903
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.74367
PCSK1 proprotein convertase subtilisin/kexin type 1 1.62569
FN3KRP fructosamine 3 kinase related protein 1.61356
HK1 hexokinase 1 1.58223
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 1.47477
FTO fat mass and obesity associated 1.39702
GCK glucokinase (hexokinase 4) 1.39702
MAEA macrophage erythroblast attacher 1.37597
HFE hemochromatosis 1.36401
C2CD4A C2 calcium-dependent domain containing 4A 1.35663
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.24793
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.17894
ADRA2A adrenoceptor alpha 2A 1.13588
HHEX hematopoietically expressed homeobox 1.09588
GCKR glucokinase (hexokinase 4) regulator 1.09588
FADS1 fatty acid desaturase 1 1.07383
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.06123
CRY2 cryptochrome circadian clock 2 1.02486
TMPRSS6 transmembrane protease, serine 6 0.995303
GLIS3 GLIS family zinc finger 3 0.965481
MTNR1B melatonin receptor 1B 0.945428
CETP cholesteryl ester transfer protein, plasma 0.945428
APOC1 apolipoprotein C-I 0.932337
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.901326
GIPR gastric inhibitory polypeptide receptor 0.85991
PROX1 prospero homeobox 1 0.830123
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.817078
FITM2 fat storage-inducing transmembrane protein 2 0.817078
ARPIN actin-related protein 2/3 complex inhibitor 0.790827
GCC1 GRIP and coiled-coil domain containing 1 0.752991
ZFAND3 zinc finger, AN1-type domain 3 0.69843
LARP6 La ribonucleoprotein domain family, member 6 0.69843
PAX4 paired box 4 0.69843
PRC1 protein regulator of cytokinesis 1 0.69843
HNF4A hepatocyte nuclear factor 4, alpha 0.682635
DUSP9 dual specificity phosphatase 9 0.682635
SPC25 SPC25, NDC80 kinetochore complex component 0.661797
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.647573
TP53INP1 tumor protein p53 inducible nuclear protein 1 0.63207
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.63207
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.63207
THADA thyroid adenoma associated 0.63207
IGF1 insulin-like growth factor 1 (somatomedin C) 0.602429
FAM58A family with sequence similarity 58, member A 0.602429
C11ORF65 chromosome 11 open reading frame 65 0.58494
SRR serine racemase 0.58494
SGSM2 small G protein signaling modulator 2 0.58494
JAZF1 JAZF zinc finger 1 0.58494
SPTA1 spectrin, alpha, erythrocytic 1 0.58494
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.572184
HMGA2 high mobility group AT-hook 2 0.572184
ATP11AUN ATP11A upstream neighbor 0.561725
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.561725
SPRY2 sprouty homolog 2 (Drosophila) 0.552621
GRK5 G protein-coupled receptor kinase 5 0.544585
LAMA1 laminin, alpha 1 0.537125
PEPD peptidase D 0.52461
HMG20A high mobility group 20A 0.52461
CTBP1-AS2 CTBP1 antisense RNA 2 (head to head) 0.52461
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.52461
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.52461
ANK1 ankyrin 1, erythrocytic 0.52461
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.52461
WFS1 Wolfram syndrome 1 (wolframin) 0.52461
CDC123 cell division cycle 123 0.52461
KCNK16 potassium channel, two pore domain subfamily K, member 16 0.486425
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.486425
APOB apolipoprotein B 0.486425
HNF1A HNF1 homeobox A 0.486425
OASL 2'-5'-oligoadenylate synthetase-like 0.486425
ZMAT4 zinc finger, matrin-type 4 0.486425
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.464771
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.464771
SDHAF4 succinate dehydrogenase complex assembly factor 4 0.464771
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 0.464771
C2CD4B C2 calcium-dependent domain containing 4B 0.449873
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.449873
NOTCH2 notch 2 0.449873
ADCY5 adenylate cyclase 5 0.429338
FZD3 frizzled class receptor 3 0.4215
TMEM163 transmembrane protein 163 0.4215
PSRC1 proline/serine-rich coiled-coil 1 0.408752
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.403461
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.403461
MTAP methylthioadenosine phosphorylase 0.403461
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.403461
SNX7 sorting nexin 7 0.368757
AHI1 Abelson helper integration site 1 0.368757
DCD dermcidin 0.368757
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 0.368757
NOG noggin 0.368757
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 0.368757
THSD4 thrombospondin, type I, domain containing 4 0.345945
CXCR4 chemokine (C-X-C motif) receptor 4 0.327313
PCNXL2 pecanex-like 2 (Drosophila) 0.327313
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.327313
ARHGAP15 Rho GTPase activating protein 15 0.327313
LPL lipoprotein lipase 0.311576
CADPS Ca++-dependent secretion activator 0.297866
SEC61G Sec61 gamma subunit 0.297866
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.297866
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.297866
CAMTA1 calmodulin binding transcription activator 1 0.297866
ZSWIM3 zinc finger, SWIM-type containing 3 0.297866
CETN3 centrin, EF-hand protein, 3 0.285417
PCNX pecanex homolog (Drosophila) 0.285417
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.285417
ADAD2 adenosine deaminase domain containing 2 0.274608
IDE insulin-degrading enzyme 0.264872
AZIN1 antizyme inhibitor 1 0.264872
LIPC lipase, hepatic 0.256228
FAM155A family with sequence similarity 155, member A 0.256228
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.256228
PCBP3 poly(rC) binding protein 3 0.256228
SYT1 synaptotagmin I 0.256228
ZBTB20 zinc finger and BTB domain containing 20 0.256228
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.256228
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.256228
TSPAN8 tetraspanin 8 0.256228
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.256228
SLC31A2 solute carrier family 31 (copper transporter), member 2 0.256228
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.197766
HNF1B HNF1 homeobox B 0.197766
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.197766
MPHOSPH6 M-phase phosphoprotein 6 0.197766
TEDDM1 transmembrane epididymal protein 1 0.197766
RBMS1 RNA binding motif, single stranded interacting protein 1 0.197766
RBM26 RNA binding motif protein 26 0.197766
PDS5B PDS5 cohesin associated factor B 0.197766
ZNF385D zinc finger protein 385D 0.197766
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.197766
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 0.197766
KCNU1 potassium channel, subfamily U, member 1 0.197766
PPARG peroxisome proliferator-activated receptor gamma 0.197766
WISP1 WNT1 inducible signaling pathway protein 1 0.197766
STXBP6 syntaxin binding protein 6 (amisyn) 0.197766
RBM38 RNA binding motif protein 38 0.197766
RHOU ras homolog family member U 0.197766
BTG1 B-cell translocation gene 1, anti-proliferative 0.197766
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.197766
KIF11 kinesin family member 11 0.197766
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.15771
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.15771
AMPD3 adenosine monophosphate deaminase 3 0.15771
PDE4B phosphodiesterase 4B, cAMP-specific 0.15771
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.15771
CNTN6 contactin 6 0.15771
ZBTB16 zinc finger and BTB domain containing 16 0.15771
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.15771
PALM2 paralemmin 2 0.15771
ZPLD1 zona pellucida-like domain containing 1 0.15771
SPATA31B1P SPATA31 subfamily B, member 1, pseudogene 0.15771
PLAC9 placenta-specific 9 0.15771
ADIPOQ adiponectin, C1Q and collagen domain containing 0.126165
SCARB2 scavenger receptor class B, member 2 0.126165
TGFBR3 transforming growth factor, beta receptor III 0.126165
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.126165
CCBE1 collagen and calcium binding EGF domains 1 0.126165
NTN1 netrin 1 0.126165
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.126165
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.126165
VEGFA vascular endothelial growth factor A 0.126165
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.126165
GAS1 growth arrest-specific 1 0.126165
AKR1E2 aldo-keto reductase family 1, member E2 0.126165
HUNK hormonally up-regulated Neu-associated kinase 0.126165
TBC1D21 TBC1 domain family, member 21 0.126165
KLHL42 kelch-like family member 42 0.126165
ZFPM2 zinc finger protein, FOG family member 2 0.126165
HDAC9 histone deacetylase 9 0.126165
SNURF SNRPN upstream reading frame 0.126165
ZNF350 zinc finger protein 350 0.100789
MED13L mediator complex subunit 13-like 0.100789
SYK spleen tyrosine kinase 0.100789
ANXA11 annexin A11 0.100789
PTH1R parathyroid hormone 1 receptor 0.100789
SHROOM2 shroom family member 2 0.100789
ARID1B AT rich interactive domain 1B (SWI1-like) 0.100789
TCERG1L transcription elongation regulator 1-like 0.100789
PTPDC1 protein tyrosine phosphatase domain containing 1 0.100789
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.100789
PTGFRN prostaglandin F2 receptor inhibitor 0.100789
ACHE acetylcholinesterase (Yt blood group) 0.100789
FAM83B family with sequence similarity 83, member B 0.100789
ASS1P10 argininosuccinate synthetase 1 pseudogene 10 0.100789
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.100789
CDH13 cadherin 13 0.100789
POU5F1B POU class 5 homeobox 1B 0.100789
BPI bactericidal/permeability-increasing protein 0.100789
DGKB diacylglycerol kinase, beta 90kDa 0.100789
CASR calcium-sensing receptor 0.100789
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.100789
REEP3 receptor accessory protein 3 0.100789
ADGRV1 adhesion G protein-coupled receptor V1 0.100789
PRDM5 PR domain containing 5 0.100789
CCNJL cyclin J-like 0.100789
POM121L4P POM121 transmembrane nucleoporin-like 4 pseudogene 0.100789
SEC23A Sec23 homolog A (S. cerevisiae) 0.100789
PDZD2 PDZ domain containing 2 0.100789
PRKD1 protein kinase D1 0.080593
PTPRD protein tyrosine phosphatase, receptor type, D 0.080593
PTPRM protein tyrosine phosphatase, receptor type, M 0.080593
SEC16B SEC16 homolog B (S. cerevisiae) 0.080593
SEZ6L seizure related 6 homolog (mouse)-like 0.080593
AMY1A amylase, alpha 1A (salivary) 0.080593
BNC2 basonuclin 2 0.080593
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.080593
TMEM61 transmembrane protein 61 0.080593
CFB complement factor B 0.080593
TMEM135 transmembrane protein 135 0.080593
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.080593
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 0.080593
IGFBP3 insulin-like growth factor binding protein 3 0.080593
CHSY3 chondroitin sulfate synthase 3 0.064973
ALPP alkaline phosphatase, placental 0.064973
TRERF1 transcriptional regulating factor 1 0.064973
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 0.064973
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.064973
SLC44A3 solute carrier family 44, member 3 0.064973
XXYLT1 xyloside xylosyltransferase 1 0.064973
USP12 ubiquitin specific peptidase 12 0.064973
PEX5L peroxisomal biogenesis factor 5-like 0.064973
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 0.064973
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.064973
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.064973
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 0.064973
STAC SH3 and cysteine rich domain 0.064973
SAP30L SAP30-like 0.064973
TCEAL2 transcription elongation factor A (SII)-like 2 0.064973
SI sucrase-isomaltase (alpha-glucosidase) 0.052255
ZNF239 zinc finger protein 239 0.052255
CHUK conserved helix-loop-helix ubiquitous kinase 0.052255
LINC00523 long intergenic non-protein coding RNA 523 0.052255
IL1B interleukin 1, beta 0.052255
ANKRD50 ankyrin repeat domain 50 0.052255
PRL prolactin 0.052255
CCDC33 coiled-coil domain containing 33 0.052255
CPVL carboxypeptidase, vitellogenic-like 0.052255
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.052255
CDK1 cyclin-dependent kinase 1 0.052255
COL4A1 collagen, type IV, alpha 1 0.052255
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 0.052255
STK32C serine/threonine kinase 32C 0.052255
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.043246
C8ORF48 chromosome 8 open reading frame 48 0.043246
MACROD2 MACRO domain containing 2 0.043246
LPIN2 lipin 2 0.043246
CCDC92 coiled-coil domain containing 92 0.043246
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.043246
WWOX WW domain containing oxidoreductase 0.043246
TRAFD1 TRAF-type zinc finger domain containing 1 0.043246
PLS1 plastin 1 0.043246
KLHL1 kelch-like family member 1 0.043246
OR7E85P olfactory receptor, family 7, subfamily E, member 85 pseudogene 0.043246
RPL6 ribosomal protein L6 0.043246
OLIG2 oligodendrocyte lineage transcription factor 2 0.043246
PAPL iron/zinc purple acid phosphatase-like protein 0.043246
ICA1 islet cell autoantigen 1, 69kDa 0.043246
C1ORF95 chromosome 1 open reading frame 95 0.043246
ARGLU1 arginine and glutamate rich 1 0.035343
FOXP1 forkhead box P1 0.035343
KIAA1671 KIAA1671 0.035343
ZFAND6 zinc finger, AN1-type domain 6 0.035343
ULBP3 UL16 binding protein 3 0.035343
DSG3 desmoglein 3 0.035343
VAV2 vav 2 guanine nucleotide exchange factor 0.035343
TSPAN5 tetraspanin 5 0.035343
PTPRR protein tyrosine phosphatase, receptor type, R 0.035343
IL1A interleukin 1, alpha 0.035343
ANTXR2 anthrax toxin receptor 2 0.035343
ZNF608 zinc finger protein 608 0.035343