type 1 diabetes mellitus Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas. (Human Disease Ontology, DOID_9744)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:9744
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Genes

170 genes associated with the disease type 1 diabetes mellitus in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 4.12722
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 3.60873
C6ORF10 chromosome 6 open reading frame 10 3.45343
INS insulin 3.44783
C6ORF47 chromosome 6 open reading frame 47 3.23488
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.2235
NOTCH4 notch 4 3.19889
PRRC2A proline-rich coiled-coil 2A 3.19256
BAG6 BCL2-associated athanogene 6 3.151
PPT2 palmitoyl-protein thioesterase 2 3.14258
HSPA1L heat shock 70kDa protein 1-like 3.13712
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.1343
VWA7 von Willebrand factor A domain containing 7 3.12096
TNXB tenascin XB 3.10532
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 3.09783
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 3.09036
HLA-DOB major histocompatibility complex, class II, DO beta 3.05269
HSPA1B heat shock 70kDa protein 1B 3.04239
MICB MHC class I polypeptide-related sequence B 3.0243
STK19 serine/threonine kinase 19 2.94494
C2 complement component 2 2.94075
CFB complement factor B 2.93484
MSH5 mutS homolog 5 2.92481
SLC44A4 solute carrier family 44, member 4 2.92276
APOM apolipoprotein M 2.91213
BTNL2 butyrophilin-like 2 2.77295
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 2.76022
IL2RA interleukin 2 receptor, alpha 2.40229
SH2B3 SH2B adaptor protein 3 2.39626
RPS26 ribosomal protein S26 2.28654
ERBB3 erb-b2 receptor tyrosine kinase 3 2.20043
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.14079
GPANK1 G patch domain and ankyrin repeats 1 2.13278
IGF2 insulin-like growth factor 2 2.09814
CLEC16A C-type lectin domain family 16, member A 1.93944
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.92727
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.90896
TCF19 transcription factor 19 1.8787
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.8787
BRD2 bromodomain containing 2 1.8787
CUX2 cut-like homeobox 2 1.8787
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.8787
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.8787
HCP5 HLA complex P5 (non-protein coding) 1.8787
C6ORF15 chromosome 6 open reading frame 15 1.8787
MICA MHC class I polypeptide-related sequence A 1.85618
CTSH cathepsin H 1.81431
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.80795
HLA-C major histocompatibility complex, class I, C 1.79991
HLA-B major histocompatibility complex, class I, B 1.7969
IFIH1 interferon induced with helicase C domain 1 1.77455
FLOT1 flotillin 1 1.76899
HCG18 HLA complex group 18 (non-protein coding) 1.74025
ABHD16A abhydrolase domain containing 16A 1.72655
LOC100287329 uncharacterized LOC100287329 1.72042
KIAA1109 KIAA1109 1.7088
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 1.70863
GSDMB gasdermin B 1.70502
RNF39 ring finger protein 39 1.69097
DPCR1 diffuse panbronchiolitis critical region 1 1.68245
GPSM3 G-protein signaling modulator 3 1.67639
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.66787
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.65612
GLIS3 GLIS family zinc finger 3 1.65612
FCRL3 Fc receptor-like 3 1.63837
SIRPG signal-regulatory protein gamma 1.63837
CCDC101 coiled-coil domain containing 101 1.63363
CD69 CD69 molecule 1.62029
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.61785
PRKD2 protein kinase D2 1.60875
ZNRD1 zinc ribbon domain containing 1 1.60002
LY6G5B lymphocyte antigen 6 complex, locus G5B 1.59682
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.59373
LMO7 LIM domain 7 1.59102
TRIM31 tripartite motif containing 31 1.58215
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.57701
TYK2 tyrosine kinase 2 1.57556
MEG3 maternally expressed 3 (non-protein coding) 1.57556
TRIM40 tripartite motif containing 40 1.57006
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene) 1.55873
AGER advanced glycosylation end product-specific receptor 1.55418
LOC100294145 uncharacterized LOC100294145 1.55208
HCG23 HLA complex group 23 (non-protein coding) 1.54808
PPP1R18 protein phosphatase 1, regulatory subunit 18 1.54
MUC21 mucin 21, cell surface associated 1.52268
CD226 CD226 molecule 1.50906
VARS2 valyl-tRNA synthetase 2, mitochondrial 1.49169
UBASH3A ubiquitin associated and SH3 domain containing A 1.48714
TH tyrosine hydroxylase 1.47656
EFR3B EFR3 homolog B (S. cerevisiae) 1.46277
HCG9 HLA complex group 9 (non-protein coding) 1.46232
SKAP2 src kinase associated phosphoprotein 2 1.45471
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.43969
GAB3 GRB2-associated binding protein 3 1.43537
HCG26 HLA complex group 26 (non-protein coding) 1.42668
AFF3 AF4/FMR2 family, member 3 1.42467
POU5F1 POU class 5 homeobox 1 1.40417
COL1A2 collagen, type I, alpha 2 1.40115
IL10 interleukin 10 1.39371
LY6G5C lymphocyte antigen 6 complex, locus G5C 1.3869
BNC2 basonuclin 2 1.36236
LTA lymphotoxin alpha 1.3566
LST1 leukocyte specific transcript 1 1.35187
CLEC2D C-type lectin domain family 2, member D 1.34719
SNORD48 small nucleolar RNA, C/D box 48 1.3316
PSORS1C3 psoriasis susceptibility 1 candidate 3 (non-protein coding) 1.3308
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.32506
C1QTNF6 C1q and tumor necrosis factor related protein 6 1.32422
PRKCQ protein kinase C, theta 1.31635
ERBB4 erb-b2 receptor tyrosine kinase 4 1.28906
PGM1 phosphoglucomutase 1 1.25477
IL2 interleukin 2 1.24194
JAZF1-AS1 JAZF1 antisense RNA 1 1.24194
DNAH2 dynein, axonemal, heavy chain 2 1.24194
ZFP36L1 ZFP36 ring finger protein-like 1 1.22228
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.22209
HPSE2 heparanase 2 (inactive) 1.21019
AQP4-AS1 AQP4 antisense RNA 1 1.19609
CENPW centromere protein W 1.1572
RNF10 ring finger protein 10 1.14463
LPAR3 lysophosphatidic acid receptor 3 1.14463
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 1.12739
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 1.10764
TENM2 teneurin transmembrane protein 2 1.07748
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 1.07599
FSTL4 follistatin-like 4 1.04846
NRIP1 nuclear receptor interacting protein 1 1.0164
CFDP1 craniofacial development protein 1 1.01307
DNAH8 dynein, axonemal, heavy chain 8 1.00653
IL7R interleukin 7 receptor 0.986376
CAPSL calcyphosine-like 0.986376
EFCAB8 EF-hand calcium binding domain 8 0.971169
MAPK14 mitogen-activated protein kinase 14 0.957195
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.931899
GRIK2 glutamate receptor, ionotropic, kainate 2 0.93103
AMZ1 archaelysin family metallopeptidase 1 0.928472
PDE4A phosphodiesterase 4A, cAMP-specific 0.925175
CTSB cathepsin B 0.923572
ZNF451 zinc finger protein 451 0.897579
CNTN6 contactin 6 0.895044
AGBL1 ATP/GTP binding protein-like 1 0.892579
STAT4 signal transducer and activator of transcription 4 0.890183
HORMAD2 HORMA domain containing 2 0.889009
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.885252
APLF aprataxin and PNKP like factor 0.865448
AP4B1 adaptor-related protein complex 4, beta 1 subunit 0.845646
OPCML opioid binding protein/cell adhesion molecule-like 0.838994
ACOXL acyl-CoA oxidase-like 0.831584
TENM4 teneurin transmembrane protein 4 0.824363
SAA2 serum amyloid A2 0.822728
ZNF536 zinc finger protein 536 0.807358
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.807012
FUT2 fucosyltransferase 2 (secretor status included) 0.786631
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.780738
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.77375
TULP4 tubby like protein 4 0.772353
TMEM170A transmembrane protein 170A 0.764659
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.759585
THADA thyroid adenoma associated 0.751629
NCALD neurocalcin delta 0.743756
CDKN2B-AS1 CDKN2B antisense RNA 1 0.736216
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.732156
KANSL1 KAT8 regulatory NSL complex subunit 1 0.727991
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.717397
DUSP16 dual specificity phosphatase 16 0.699446
VGLL4 vestigial-like family member 4 0.695042
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 0.685698
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.678541
ZPBP2 zona pellucida binding protein 2 0.565109
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 0.531226