type 1 diabetes mellitus Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas. (Human Disease Ontology, DOID_9744)
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Genes

258 genes co-occuring with the disease type 1 diabetes mellitus in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
INS insulin 3.21065
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.53527
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.0225
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.99872
GCG glucagon 1.96755
ALB albumin 1.96661
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.9328
HBA1 hemoglobin, alpha 1 1.89082
HBA2 hemoglobin, alpha 2 1.87331
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 1.76818
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.6507
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.62381
PTPRN protein tyrosine phosphatase, receptor type, N 1.59787
LAD1 ladinin 1 1.58626
HLA-C major histocompatibility complex, class I, C 1.46407
IGF1 insulin-like growth factor 1 (somatomedin C) 1.41227
PTPN3 protein tyrosine phosphatase, non-receptor type 3 1.40833
CD4 CD4 molecule 1.38952
IL1B interleukin 1, beta 1.38472
IGFBP1 insulin-like growth factor binding protein 1 1.28872
ICA1 islet cell autoantigen 1, 69kDa 1.28261
ACE angiotensin I converting enzyme 1.28217
SUMO4 small ubiquitin-like modifier 4 1.26865
HLA-A major histocompatibility complex, class I, A 1.23169
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.19532
PPY pancreatic polypeptide 1.18066
SST somatostatin 1.17808
CD79A CD79a molecule, immunoglobulin-associated alpha 1.17464
HLA-B major histocompatibility complex, class I, B 1.16606
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.15496
PTPRD protein tyrosine phosphatase, receptor type, D 1.14772
APOB apolipoprotein B 1.1194
IGFBP3 insulin-like growth factor binding protein 3 1.11772
IAPP islet amyloid polypeptide 1.1051
MICA MHC class I polypeptide-related sequence A 1.07908
TPO thyroid peroxidase 1.0669
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 1.0484
TNF tumor necrosis factor 1.03493
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.03198
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.02735
INSR insulin receptor 1.00668
C4A complement component 4A (Rodgers blood group) 1.00583
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.991065
INSM2 insulinoma-associated 2 0.961634
GCK glucokinase (hexokinase 4) 0.949519
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.94577
TG thyroglobulin 0.93497
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.906498
LPA lipoprotein, Lp(a) 0.890488
HLA-E major histocompatibility complex, class I, E 0.889668
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.889668
LEP leptin 0.88434
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.867549
BGLAP bone gamma-carboxyglutamate (gla) protein 0.865912
WDR11 WD repeat domain 11 0.843802
WFS1 Wolfram syndrome 1 (wolframin) 0.836427
AIRE autoimmune regulator 0.831099
GHR growth hormone receptor 0.816334
ICAM1 intercellular adhesion molecule 1 0.811411
REN renin 0.81018
ALLC allantoicase 0.795411
LTA lymphotoxin alpha 0.788442
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.765535
CFB complement factor B 0.754934
APOA1 apolipoprotein A-I 0.752898
HNF1A HNF1 homeobox A 0.74883
DNAH8 dynein, axonemal, heavy chain 8 0.748017
GHRH growth hormone releasing hormone 0.738676
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 0.737865
SOD2 superoxide dismutase 2, mitochondrial 0.735027
PAX4 paired box 4 0.733001
VWF von Willebrand factor 0.729357
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 0.716828
SOX13 SRY (sex determining region Y)-box 13 0.714005
NPPA natriuretic peptide A 0.706351
APOA2 apolipoprotein A-II 0.690293
PRSS16 protease, serine, 16 (thymus) 0.669936
NIT1 nitrilase 1 0.662784
IL2 interleukin 2 0.658422
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.656441
CSN1S1 casein alpha s1 0.641039
IL2RA interleukin 2 receptor, alpha 0.637102
TGFB1 transforming growth factor, beta 1 0.626888
POMC proopiomelanocortin 0.625711
HLA-DMA major histocompatibility complex, class II, DM alpha 0.615921
TRH thyrotropin-releasing hormone 0.612011
CD80 CD80 molecule 0.604201
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.595233
IFNA1 interferon, alpha 1 0.589001
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.578883
B2M beta-2-microglobulin 0.578106
IL10 interleukin 10 0.575772
FOXP3 forkhead box P3 0.567609
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.562558
AMBP alpha-1-microglobulin/bikunin precursor 0.558674
CRP C-reactive protein, pentraxin-related 0.556732
TRAC T cell receptor alpha constant 0.550911
IL4 interleukin 4 0.541605
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.53928
GPX5 glutathione peroxidase 5 0.535022
SLC30A10 solute carrier family 30, member 10 0.534635
GPX1 glutathione peroxidase 1 0.534635
GPX4 glutathione peroxidase 4 0.531928
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.531541
ZDHHC23 zinc finger, DHHC-type containing 23 0.531154
GIMAP5 GTPase, IMAP family member 5 0.522659
CAT catalase 0.51919
NEUROD1 neuronal differentiation 1 0.513033
SELL selectin L 0.507273
ATAD1 ATPase family, AAA domain containing 1 0.501909
LPL lipoprotein lipase 0.499614
MYDGF myeloid-derived growth factor 0.489691
CETP cholesteryl ester transfer protein, plasma 0.488549
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.484744
PTH parathyroid hormone 0.476014
VCAM1 vascular cell adhesion molecule 1 0.476014
ALPPL2 alkaline phosphatase, placental-like 2 0.468819
ALPP alkaline phosphatase, placental 0.468441
ALPL alkaline phosphatase, liver/bone/kidney 0.468063
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 0.46655
CSN2 casein beta 0.46655
HK1 hexokinase 1 0.46466
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.459373
CD5 CD5 molecule 0.452208
FURIN furin (paired basic amino acid cleaving enzyme) 0.452208
IL6 interleukin 6 0.451078
G6PC2 glucose-6-phosphatase, catalytic, 2 0.451078
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.437906
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.430393
OR6F1 olfactory receptor, family 6, subfamily F, member 1 0.428891
GHRL ghrelin/obestatin prepropeptide 0.423265
CPE carboxypeptidase E 0.421016
IGF2 insulin-like growth factor 2 0.420266
GLS2 glutaminase 2 (liver, mitochondrial) 0.419142
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.418768
BPIFB2 BPI fold containing family B, member 2 0.41727
PRDX4 peroxiredoxin 4 0.411657
CSH2 chorionic somatomammotropin hormone 2 0.410161
THBD thrombomodulin 0.407919
DYNLT1 dynein, light chain, Tctex-type 1 0.401572
IFIH1 interferon induced with helicase C domain 1 0.401572
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.398962
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) 0.395608
MPP1 membrane protein, palmitoylated 1, 55kDa 0.395608
MPHOSPH6 M-phase phosphoprotein 6 0.395608
GIF gastric intrinsic factor (vitamin B synthesis) 0.388538
STYX serine/threonine/tyrosine interacting protein 0.387051
PRF1 perforin 1 (pore forming protein) 0.383708
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.372587
SHPK sedoheptulokinase 0.36704
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 0.366671
GGCT gamma-glutamylcyclotransferase 0.364454
NELFCD negative elongation factor complex member C/D 0.362978
IARS isoleucyl-tRNA synthetase 0.353763
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.346409
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.340539
BBX bobby sox homolog (Drosophila) 0.33651
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.336144
APOO apolipoprotein O 0.335046
CD40 CD40 molecule, TNF receptor superfamily member 5 0.333218
COG2 component of oligomeric golgi complex 2 0.331756
NLRP14 NLR family, pyrin domain containing 14 0.324094
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.323002
FASLG Fas ligand (TNF superfamily, member 6) 0.317545
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.313915
APOC3 apolipoprotein C-III 0.312464
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.309204
CXCL10 chemokine (C-X-C motif) ligand 10 0.305948
IL1A interleukin 1, alpha 0.304864
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.300533
PDCD1 programmed cell death 1 0.298371
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.298371
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.297651
SHBG sex hormone-binding globulin 0.296931
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 0.293694
IGLV5-52 immunoglobulin lambda variable 5-52 0.287952
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.286877
CAPSL calcyphosine-like 0.286519
UFL1 UFM1-specific ligase 1 0.28616
RPS15 ribosomal protein S15 0.285086
SELE selectin E 0.283297
OR13J1 olfactory receptor, family 13, subfamily J, member 1 0.282225
CD40LG CD40 ligand 0.278297
ISL1 ISL LIM homeobox 1 0.270464
SDC2 syndecan 2 0.265494
CCL2 chemokine (C-C motif) ligand 2 0.260184
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.258417
IL18 interleukin 18 0.257358
TADA1 transcriptional adaptor 1 0.250663
APOE apolipoprotein E 0.250311
TF transferrin 0.249608
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.248905
PLGLB1 plasminogen-like B1 0.243645
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.241895
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.241196
FBXL7 F-box and leucine-rich repeat protein 7 0.240497
PDX1 pancreatic and duodenal homeobox 1 0.239101
SCO1 SCO1 cytochrome c oxidase assembly protein 0.235616
HMX1 H6 family homeobox 1 0.233878
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.233183
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.231795
PRL prolactin 0.230755
GPR83 G protein-coupled receptor 83 0.22937
CP ceruloplasmin (ferroxidase) 0.226262
DLL1 delta-like 1 (Drosophila) 0.225917
PER2 period circadian clock 2 0.225229
HADH hydroxyacyl-CoA dehydrogenase 0.218034
GLO1 glyoxalase I 0.215653
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.213959
IL1RN interleukin 1 receptor antagonist 0.212945
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 0.212271
FRMPD1 FERM and PDZ domain containing 1 0.208579
PLG plasminogen 0.207245
THY1 Thy-1 cell surface antigen 0.20658
TUBB4B tubulin, beta 4B class IVb 0.20658
FN1 fibronectin 1 0.204593
PTPRC protein tyrosine phosphatase, receptor type, C 0.201962
GH1 growth hormone 1 0.199681
ART3 ADP-ribosyltransferase 3 0.199681
CABIN1 calcineurin binding protein 1 0.19742
MGAM maltase-glucoamylase 0.19742
CD3D CD3d molecule, delta (CD3-TCR complex) 0.196139
DPT dermatopontin 0.193915
AFP alpha-fetoprotein 0.192657
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.191097
GANC glucosidase, alpha; neutral C 0.190786
PGM1 phosphoglucomutase 1 0.189859
CD86 CD86 molecule 0.188632
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.187415
NOS3 nitric oxide synthase 3 (endothelial cell) 0.18621
LEPR leptin receptor 0.184424
GAST gastrin 0.183541
SCN2A sodium channel, voltage gated, type II alpha subunit 0.182086
SP7 Sp7 transcription factor 0.181798
CBR1 carbonyl reductase 1 0.180084
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 0.17952
DMXL2 Dmx-like 2 0.179239
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.176485
SOST sclerostin 0.173571
GIP gastric inhibitory polypeptide 0.173314
TCHH trichohyalin 0.172291
TLR4 toll-like receptor 4 0.172291
PON1 paraoxonase 1 0.172038
PLAT plasminogen activator, tissue 0.170789
HP haptoglobin 0.168854
HLA-DOB major histocompatibility complex, class II, DO beta 0.168148
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.166544
HPR haptoglobin-related protein 0.165217
AGTR1 angiotensin II receptor, type 1 0.161331
HSPA4 heat shock 70kDa protein 4 0.161139
ZNF410 zinc finger protein 410 0.160948
TTC3 tetratricopeptide repeat domain 3 0.160021
EDN1 endothelin 1 0.159658
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.159658
ADRB2 adrenoceptor beta 2, surface 0.159124
DLX3 distal-less homeobox 3 0.158434
RETN resistin 0.157929
PER1 period circadian clock 1 0.157765