type 1 diabetes mellitus Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas. (Human Disease Ontology, DOID_9744)
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Genes

144 genes associated with the disease type 1 diabetes mellitus in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.41121
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.28
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.24724
ASCL2 achaete-scute family bHLH transcription factor 2 2.16747
RSBN1 round spermatid basic protein 1 2.0599
IL2RA interleukin 2 receptor, alpha 1.98621
SH2B3 SH2B adaptor protein 3 1.97358
RNLS renalase, FAD-dependent amine oxidase 1.70133
MICA MHC class I polypeptide-related sequence A 1.63542
NOTCH4 notch 4 1.59286
PRRC2A proline-rich coiled-coil 2A 1.57113
LY6G6C lymphocyte antigen 6 complex, locus G6C 1.56115
C6ORF25 chromosome 6 open reading frame 25 1.56115
BAG6 BCL2-associated athanogene 6 1.55524
GPANK1 G patch domain and ankyrin repeats 1 1.54448
VWA7 von Willebrand factor A domain containing 7 1.47477
NEU1 sialidase 1 (lysosomal sialidase) 1.41058
HLA-C major histocompatibility complex, class I, C 1.37597
ERBB3 erb-b2 receptor tyrosine kinase 3 1.37597
TNXB tenascin XB 1.341
ATF6B activating transcription factor 6 beta 1.33613
HLA-DOB major histocompatibility complex, class II, DO beta 1.33613
IKZF4 IKAROS family zinc finger 4 (Eos) 1.258
HSPA1L heat shock 70kDa protein 1-like 1.24793
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.20753
STK19 serine/threonine kinase 19 1.18942
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 1.17894
MICB MHC class I polypeptide-related sequence B 1.17894
SLC44A4 solute carrier family 44, member 4 1.17894
APOM apolipoprotein M 1.17894
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.17894
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 1.17894
C6ORF47 chromosome 6 open reading frame 47 1.17894
HLA-B major histocompatibility complex, class I, B 1.17894
DPCR1 diffuse panbronchiolitis critical region 1 1.17894
CFB complement factor B 1.17894
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.17894
C6ORF15 chromosome 6 open reading frame 15 1.17894
CLEC16A C-type lectin domain family 16, member A 1.14929
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.14929
HORMAD2 HORMA domain containing 2 1.13588
MTMR3 myotubularin related protein 3 1.13588
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.09588
CTRB1 chymotrypsinogen B1 1.06123
CTSH cathepsin H 1.06123
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.02486
C6ORF48 chromosome 6 open reading frame 48 0.971299
RPP21 ribonuclease P/MRP 21kDa subunit 0.965481
RBM17 RNA binding motif protein 17 0.965481
ABHD16A abhydrolase domain containing 16A 0.945428
LTA lymphotoxin alpha 0.932337
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.932337
MUC21 mucin 21, cell surface associated 0.932337
CENPW centromere protein W 0.923046
TUBB tubulin, beta class I 0.923046
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.916033
KIAA1109 KIAA1109 0.916033
GSDMB gasdermin B 0.910378
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 0.894262
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.894262
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.894262
BRD2 bromodomain containing 2 0.872896
IER3 immediate early response 3 0.85991
NCR3 natural cytotoxicity triggering receptor 3 0.85991
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.85991
FCRL3 Fc receptor-like 3 0.817078
TRIM26 tripartite motif containing 26 0.817078
SIRPG signal-regulatory protein gamma 0.817078
PRRT1 proline-rich transmembrane protein 1 0.790827
CD69 CD69 molecule 0.790827
HLA-DMA major histocompatibility complex, class II, DM alpha 0.790827
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.790827
IFIH1 interferon induced with helicase C domain 1 0.790827
PRKD2 protein kinase D2 0.774217
ZNRD1 zinc ribbon domain containing 1 0.7623
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.752991
LY6G5B lymphocyte antigen 6 complex, locus G5B 0.752991
LMO7 LIM domain 7 0.745324
TRIM31 tripartite motif containing 31 0.73332
TYK2 tyrosine kinase 2 0.724323
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.724323
MEG3 maternally expressed 3 (non-protein coding) 0.724323
TRIM40 tripartite motif containing 40 0.724323
LY6G6F lymphocyte antigen 6 complex, locus G6F 0.69843
OR5V1 olfactory receptor, family 5, subfamily V, member 1 0.682635
HLA-E major histocompatibility complex, class I, E 0.682635
AIF1 allograft inflammatory factor 1 0.670996
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.670996
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.63207
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.602429
OR2H1 olfactory receptor, family 2, subfamily H, member 1 0.602429
IL10 interleukin 10 0.602429
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.602429
HIST1H3H histone cluster 1, H3h 0.58494
TH tyrosine hydroxylase 0.58494
HLA-J major histocompatibility complex, class I, J (pseudogene) 0.572184
EFR3B EFR3 homolog B (S. cerevisiae) 0.572184
LOC399716 uncharacterized LOC399716 0.572184
SKAP2 src kinase associated phosphoprotein 2 0.561725
HLA-DOA major histocompatibility complex, class II, DO alpha 0.561725
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.544585
RING1 ring finger protein 1 0.544585
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.544585
DLL1 delta-like 1 (Drosophila) 0.537125
GAB3 GRB2-associated binding protein 3 0.537125
NUPR1 nuclear protein, transcriptional regulator, 1 0.52461
CD226 CD226 molecule 0.52461
COL1A2 collagen, type I, alpha 2 0.486425
LY6G5C lymphocyte antigen 6 complex, locus G5C 0.486425
POU5F1 POU class 5 homeobox 1 0.486425
MAS1L MAS1 proto-oncogene like, G protein-coupled receptor 0.486425
COBL cordon-bleu WH2 repeat protein 0.449873
ZNF311 zinc finger protein 311 0.438544
HIST1H2BN histone cluster 1, H2bn 0.438544
ZNF438 zinc finger protein 438 0.438544
UBASH3A ubiquitin associated and SH3 domain containing A 0.403461
PRKCQ protein kinase C, theta 0.403461
IGF2-AS IGF2 antisense RNA 0.368757
IGF2 insulin-like growth factor 2 0.368757
INS insulin 0.368757
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.368757
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.368757
UMOD uromodulin 0.368757
PGM1 phosphoglucomutase 1 0.327313
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.327313
JAZF1 JAZF zinc finger 1 0.311576
IL2 interleukin 2 0.311576
DNAH2 dynein, axonemal, heavy chain 2 0.311576
FOSL2 FOS-like antigen 2 0.274608
HPSE2 heparanase 2 (inactive) 0.274608
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.256228
ZPBP2 zona pellucida binding protein 2 0.197766
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.197766
LPAR3 lysophosphatidic acid receptor 3 0.197766
IL2RB interleukin 2 receptor, beta 0.197766
FGF4 fibroblast growth factor 4 0.15771
TNP2 transition protein 2 (during histone to protamine replacement) 0.15771
GLIS3 GLIS family zinc finger 3 0.15771
NCOA1 nuclear receptor coactivator 1 0.126165
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.100789
IL25 interleukin 25 0.080593
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.080593
IL7R interleukin 7 receptor 0.052255
CAPSL calcyphosine-like 0.052255