tyloxapol-3074 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the tyloxapol-3074 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACVRL1 activin A receptor type II-like 1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALOX5 arachidonate 5-lipoxygenase
ARMCX1 armadillo repeat containing, X-linked 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
B9D1 B9 protein domain 1
BIN1 bridging integrator 1
CD248 CD248 molecule, endosialin
CFAP45 cilia and flagella associated protein 45
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL10A1 collagen, type X, alpha 1
COL17A1 collagen, type XVII, alpha 1
COL1A1 collagen, type I, alpha 1
CYB561 cytochrome b561
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCAF15 DDB1 and CUL4 associated factor 15
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DLX4 distal-less homeobox 4
EFNA4 ephrin-A4
EGFR epidermal growth factor receptor
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
FAM155A family with sequence similarity 155, member A
FAM76A family with sequence similarity 76, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXO40 F-box protein 40
FCAR Fc fragment of IgA receptor
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF18 fibroblast growth factor 18
FGF4 fibroblast growth factor 4
FUBP1 far upstream element (FUSE) binding protein 1
GHRHR growth hormone releasing hormone receptor
GPC4 glypican 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GSK3A glycogen synthase kinase 3 alpha
HABP4 hyaluronan binding protein 4
HDAC6 histone deacetylase 6
HOXC8 homeobox C8
HOXD11 homeobox D11
INO80D INO80 complex subunit D
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIAA0513 KIAA0513
KLC2 kinesin light chain 2
KRT85 keratin 85, type II
LAMA4 laminin, alpha 4
LINC00474 long intergenic non-protein coding RNA 474
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGOH2P mago-nashi homolog 2, pseudogene
MB myoglobin
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCM3AP minichromosome maintenance complex component 3 associated protein
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MLXIPL MLX interacting protein-like
MPZL1 myelin protein zero-like 1
MYCT1 myc target 1
MYL10 myosin, light chain 10, regulatory
MYO6 myosin VI
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
NRF1 nuclear respiratory factor 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PDE8B phosphodiesterase 8B
PDPN podoplanin
PLCE1 phospholipase C, epsilon 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PNPLA3 patatin-like phospholipase domain containing 3
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTMS parathymosin
RAB40A RAB40A, member RAS oncogene family
RBMS2 RNA binding motif, single stranded interacting protein 2
RPL10 ribosomal protein L10
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SH2D3A SH2 domain containing 3A
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIX3 SIX homeobox 3
SLAMF8 SLAM family member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLIT2 slit homolog 2 (Drosophila)
SMAD6 SMAD family member 6
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX12 SRY (sex determining region Y)-box 12
SPON1 spondin 1, extracellular matrix protein
STAT2 signal transducer and activator of transcription 2, 113kDa
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAT tyrosine aminotransferase
TCF3 transcription factor 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMPRSS3 transmembrane protease, serine 3
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TTLL5 tubulin tyrosine ligase-like family member 5
VSIG10 V-set and immunoglobulin domain containing 10
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ANKRD40 ankyrin repeat domain 40
ARF5 ADP-ribosylation factor 5
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
AZU1 azurocidin 1
BAG4 BCL2-associated athanogene 4
BIK BCL2-interacting killer (apoptosis-inducing)
C1ORF21 chromosome 1 open reading frame 21
CAPN15 calpain 15
CCNT1 cyclin T1
CDADC1 cytidine and dCMP deaminase domain containing 1
CHML choroideremia-like (Rab escort protein 2)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNR2 cannabinoid receptor 2 (macrophage)
COL4A2 collagen, type IV, alpha 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CTSG cathepsin G
CXCL2 chemokine (C-X-C motif) ligand 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DUSP2 dual specificity phosphatase 2
EMC9 ER membrane protein complex subunit 9
ENDOG endonuclease G
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC2 excision repair cross-complementation group 2
ERI3 ERI1 exoribonuclease family member 3
EXOSC1 exosome component 1
FAM57A family with sequence similarity 57, member A
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FEM1C fem-1 homolog c (C. elegans)
FGL1 fibrinogen-like 1
FHL3 four and a half LIM domains 3
FHOD1 formin homology 2 domain containing 1
FKBP5 FK506 binding protein 5
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GPR27 G protein-coupled receptor 27
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIRA histone cell cycle regulator
HIST1H2BN histone cluster 1, H2bn
HIST1H4J histone cluster 1, H4j
IDI2-AS1 IDI2 antisense RNA 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRX5 iroquois homeobox 5
ITGA10 integrin, alpha 10
ITPKC inositol-trisphosphate 3-kinase C
KAT2A K(lysine) acetyltransferase 2A
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIF24 kinesin family member 24
LIN7A lin-7 homolog A (C. elegans)
LINC00260 long intergenic non-protein coding RNA 260
LINC00339 long intergenic non-protein coding RNA 339
LY6E lymphocyte antigen 6 complex, locus E
MAGEH1 melanoma antigen family H1
MCTP2 multiple C2 domains, transmembrane 2
MEFV Mediterranean fever
MRPS34 mitochondrial ribosomal protein S34
MTCP1 mature T-cell proliferation 1
NDE1 nudE neurodevelopment protein 1
NT5M 5',3'-nucleotidase, mitochondrial
PARP11 poly (ADP-ribose) polymerase family, member 11
PERP PERP, TP53 apoptosis effector
PES1 pescadillo ribosomal biogenesis factor 1
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLTP phospholipid transfer protein
PRAF2 PRA1 domain family, member 2
PTAFR platelet-activating factor receptor
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFXAP regulatory factor X-associated protein
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN1 Ras and Rab interactor 1
RPAP1 RNA polymerase II associated protein 1
RPP25 ribonuclease P/MRP 25kDa subunit
S100A12 S100 calcium binding protein A12
SIRT6 sirtuin 6
SKI SKI proto-oncogene
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
TCTA T-cell leukemia translocation altered
TEC tec protein tyrosine kinase
TMC5 transmembrane channel-like 5
TMEM246 transmembrane protein 246
TRPS1 trichorhinophalangeal syndrome I
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN14 tetraspanin 14
TSSC4 tumor suppressing subtransferable candidate 4
TTC26 tetratricopeptide repeat domain 26
ZDHHC11 zinc finger, DHHC-type containing 11
ZHX2 zinc fingers and homeoboxes 2
ZNF215 zinc finger protein 215
ZNF324 zinc finger protein 324
ZNF426 zinc finger protein 426
ZNF493 zinc finger protein 493