trophoblastic neoplasm Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A germ cell and embryonal cancer that derives_from trophoblastic tissue. (Human Disease Ontology, DOID_4085)
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Genes

190 genes co-occuring with the disease trophoblastic neoplasm in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
NLRP7 NLR family, pyrin domain containing 7 2.43047
CSH2 chorionic somatomammotropin hormone 2 2.11291
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.08637
KHDC3L KH domain containing 3-like, subcortical maternal complex member 1.86506
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.84681
CTSC cathepsin C 1.67367
INHA inhibin, alpha 1.59251
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.42762
PSG9 pregnancy specific beta-1-glycoprotein 9 1.42147
LGALS1 lectin, galactoside-binding, soluble, 1 1.32454
NLRP2 NLR family, pyrin domain containing 2 1.22475
PHLDA2 pleckstrin homology-like domain, family A, member 2 1.1439
STARD7 StAR-related lipid transfer (START) domain containing 7 1.11772
ZC2HC1B zinc finger, C2HC-type containing 1B 1.10889
TFPI2 tissue factor pathway inhibitor 2 1.09881
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 1.09167
RNF130 ring finger protein 130 1.09167
PSG1 pregnancy specific beta-1-glycoprotein 1 1.0606
AFP alpha-fetoprotein 1.01807
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 1.01596
PAEP progestagen-associated endometrial protein 0.897051
HLA-G major histocompatibility complex, class I, G 0.886389
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.858952
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 0.849945
HSPE1 heat shock 10kDa protein 1 0.847898
PSG6 pregnancy specific beta-1-glycoprotein 6 0.836427
SNTG1 syntrophin, gamma 1 0.792951
MCM7 minichromosome maintenance complex component 7 0.788033
CGB chorionic gonadotropin, beta polypeptide 0.781479
CGB8 chorionic gonadotropin, beta polypeptide 8 0.78066
PSG2 pregnancy specific beta-1-glycoprotein 2 0.778204
ERV3-1 endogenous retrovirus group 3, member 1 0.768801
LIG3 ligase III, DNA, ATP-dependent 0.764718
NLRP5 NLR family, pyrin domain containing 5 0.73746
TP53 tumor protein p53 0.724502
MCAM melanoma cell adhesion molecule 0.720058
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.687091
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.686291
CLIC1 chloride intracellular channel 1 0.683493
FRRS1L ferric-chelate reductase 1-like 0.678701
MMP12 matrix metallopeptidase 12 0.669538
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.665166
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.637889
GH2 growth hormone 2 0.635135
PLAGL1 pleiomorphic adenoma gene-like 1 0.631205
LNPEP leucyl/cystinyl aminopeptidase 0.624535
KRT18 keratin 18, type I 0.617094
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 0.61162
PSG5 pregnancy specific beta-1-glycoprotein 5 0.597571
ZFP57 ZFP57 zinc finger protein 0.583941
SGCE sarcoglycan, epsilon 0.575383
ZFYVE1 zinc finger, FYVE domain containing 1 0.569163
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 0.566831
ANOS1 anosmin 1 0.546256
KRT7 keratin 7, type II 0.544705
KIF7 kinesin family member 7 0.542379
HAS1 hyaluronan synthase 1 0.537344
PCTP phosphatidylcholine transfer protein 0.536183
KISS1 KiSS-1 metastasis-suppressor 0.51842
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.518034
CDC123 cell division cycle 123 0.514956
EBAG9 estrogen receptor binding site associated, antigen, 9 0.51188
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.506123
TLE4 transducin-like enhancer of split 4 0.495411
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.488549
ALPPL2 alkaline phosphatase, placental-like 2 0.486646
ALPP alkaline phosphatase, placental 0.486266
ALPL alkaline phosphatase, liver/bone/kidney 0.485505
TRH thyrotropin-releasing hormone 0.482084
PGM1 phosphoglucomutase 1 0.480566
HMP19 HMP19 protein 0.466928
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.46655
HLA-A major histocompatibility complex, class I, A 0.46466
CSHL1 chorionic somatomammotropin hormone-like 1 0.463905
PGF placental growth factor 0.448441
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.440538
MEFV Mediterranean fever 0.434524
SNRPN small nuclear ribonucleoprotein polypeptide N 0.433021
IGFBP1 insulin-like growth factor binding protein 1 0.425139
PRL prolactin 0.422515
SDC3 syndecan 3 0.41727
CAPN1 calpain 1, (mu/I) large subunit 0.41465
IGF2 insulin-like growth factor 2 0.413153
MMP23B matrix metallopeptidase 23B 0.412405
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.412405
FASLG Fas ligand (TNF superfamily, member 6) 0.410161
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.406425
PZP pregnancy-zone protein 0.400453
DUOXA1 dual oxidase maturation factor 1 0.398216
PROK1 prokineticin 1 0.393746
SYN2 synapsin II 0.391513
GALP galanin-like peptide 0.388538
ERBB2 erb-b2 receptor tyrosine kinase 2 0.385565
RHCE Rh blood group, CcEe antigens 0.382223
USP1 ubiquitin specific peptidase 1 0.371477
F2R coagulation factor II (thrombin) receptor 0.36704
CDKN2A cyclin-dependent kinase inhibitor 2A 0.364085
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.359657
FOXJ1 forkhead box J1 0.345675
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 0.343106
TMEM245 transmembrane protein 245 0.342006
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.340906
TIMP2 TIMP metallopeptidase inhibitor 2 0.331756
RNH1 ribonuclease/angiogenin inhibitor 1 0.323365
GPC1 glypican 1 0.308118
NMS neuromedin S 0.304864
SYN3 synapsin III 0.304864
ZNF436 zinc finger protein 436 0.302337
PEG3 paternally expressed 3 0.301615
BTG2 BTG family, member 2 0.300894
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.298371
IL2 interleukin 2 0.296211
EGFR epidermal growth factor receptor 0.292257
PALLD palladin, cytoskeletal associated protein 0.287235
PCNA proliferating cell nuclear antigen 0.285086
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.277227
HLA-C major histocompatibility complex, class I, C 0.274732
RAET1E retinoic acid early transcript 1E 0.273308
PI3 peptidase inhibitor 3, skin-derived 0.273308
SHF Src homology 2 domain containing F 0.272597
MUC3A mucin 3A, cell surface associated 0.269398
PTPRJ protein tyrosine phosphatase, receptor type, J 0.269043
RHD Rh blood group, D antigen 0.262306
LGALS7 lectin, galactoside-binding, soluble, 7 0.260891
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.254888
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.253479
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.242945
POLL polymerase (DNA directed), lambda 0.241895
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.23666
SOX3 SRY (sex determining region Y)-box 3 0.232142
KISS1R KISS1 receptor 0.232142
CGB7 chorionic gonadotropin, beta polypeptide 7 0.22937
CGB5 chorionic gonadotropin, beta polypeptide 5 0.227988
FANCB Fanconi anemia, complementation group B 0.222479
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.221108
RRM2 ribonucleotide reductase M2 0.218374
RFC2 replication factor C (activator 1) 2, 40kDa 0.217352
CSF1R colony stimulating factor 1 receptor 0.217012
PEG10 paternally expressed 10 0.211934
MMP9 matrix metallopeptidase 9 0.208914
SLC22A18 solute carrier family 22, member 18 0.207578
ESD esterase D 0.207578
GH1 growth hormone 1 0.20229
FOXD3 forkhead box D3 0.199033
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.19742
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 0.196779
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.196779
IGFBP7 insulin-like growth factor binding protein 7 0.196459
ZNF185 zinc finger protein 185 (LIM domain) 0.190786
HBA1 hemoglobin, alpha 1 0.188022
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.18472
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.180937
DCN decorin 0.174354
HBA2 hemoglobin, alpha 2 0.172038
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.171485
ROM1 retinal outer segment membrane protein 1 0.171286
ERAP1 endoplasmic reticulum aminopeptidase 1 0.168381
ANGPT2 angiopoietin 2 0.166768
MMP2 matrix metallopeptidase 2 0.166544
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.166544
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.165217
EED embryonic ectoderm development 0.164571
HIC1 hypermethylated in cancer 1 0.162707
ANGPT1 angiopoietin 1 0.162109
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.162109
SH2B3 SH2B adaptor protein 3 0.161331
NEFL neurofilament, light polypeptide 0.160021
ADAM12 ADAM metallopeptidase domain 12 0.159658
ERBB4 erb-b2 receptor tyrosine kinase 4 0.15948
HRAS Harvey rat sarcoma viral oncogene homolog 0.158266
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.146155
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.138206
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.136768
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.136661
MUC4 mucin 4, cell surface associated 0.134742
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.121236
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.121162
NANOG Nanog homeobox 0.120827
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.120678
LAP3 leucine aminopeptidase 3 0.120601
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.120024
CD34 CD34 molecule 0.119468
LEP leptin 0.119227
HPN hepsin 0.118775
KRT5 keratin 5, type II 0.118442
CD68 CD68 molecule 0.118399
STAT2 signal transducer and activator of transcription 2, 113kDa 0.118272
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.118187
F8 coagulation factor VIII, procoagulant component 0.11806
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.117933