troglitazone-6191 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the troglitazone-6191 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRB3 adrenoceptor beta 3
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGFG2 ArfGAP with FG repeats 2
AHNAK2 AHNAK nucleoprotein 2
ALDOB aldolase B, fructose-bisphosphate
APOM apolipoprotein M
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AVPR1A arginine vasopressin receptor 1A
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
BHMT2 betaine--homocysteine S-methyltransferase 2
BLVRA biliverdin reductase A
BPI bactericidal/permeability-increasing protein
BTF3P12 basic transcription factor 3 pseudogene 12
BTNL3 butyrophilin-like 3
C1ORF68 chromosome 1 open reading frame 68
C3ORF18 chromosome 3 open reading frame 18
CCDC186 coiled-coil domain containing 186
CCDC82 coiled-coil domain containing 82
CCDC9 coiled-coil domain containing 9
CD1E CD1e molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC42 cell division cycle 42
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDHR1 cadherin-related family member 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP41 centrosomal protein 41kDa
CSNK1E casein kinase 1, epsilon
DCN decorin
DIO2 deiodinase, iodothyronine, type II
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
EXTL1 exostosin-like glycosyltransferase 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM107A family with sequence similarity 107, member A
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF6 fibroblast growth factor 6
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GJC2 gap junction protein, gamma 2, 47kDa
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
HIPK2 homeodomain interacting protein kinase 2
HIST1H4E histone cluster 1, H4e
HOXA10 homeobox A10
HOXA7 homeobox A7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA2 heat shock 70kDa protein 2
IL16 interleukin 16
IL22 interleukin 22
INHBA inhibin, beta A
IRS1 insulin receptor substrate 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
LINC00216 long intergenic non-protein coding RNA 216
LOC644450 uncharacterized LOC644450
LRP4 low density lipoprotein receptor-related protein 4
LY6G5C lymphocyte antigen 6 complex, locus G5C
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED25 mediator complex subunit 25
MMP10 matrix metallopeptidase 10
MST1L macrophage stimulating 1-like
MTMR7 myotubularin related protein 7
NF2 neurofibromin 2 (merlin)
OSBPL10 oxysterol binding protein-like 10
PACS1 phosphofurin acidic cluster sorting protein 1
PAX5 paired box 5
PCDHGA3 protocadherin gamma subfamily A, 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLSCR3 phospholipid scramblase 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD51B RAD51 paralog B
RPL10L ribosomal protein L10-like
SECTM1 secreted and transmembrane 1
SHOX2 short stature homeobox 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNED1 sushi, nidogen and EGF-like domains 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPPL2B signal peptide peptidase like 2B
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPK2 SRSF protein kinase 2
TLN2 talin 2
TMEM53 transmembrane protein 53
TNK1 tyrosine kinase, non-receptor, 1
TXNRD3 thioredoxin reductase 3
UPP1 uridine phosphorylase 1
WDR55 WD repeat domain 55
WWOX WW domain containing oxidoreductase
YBX2 Y box binding protein 2
ZC3H13 zinc finger CCCH-type containing 13
ZNF132 zinc finger protein 132
ZNF362 zinc finger protein 362

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACP5 acid phosphatase 5, tartrate resistant
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ATAT1 alpha tubulin acetyltransferase 1
CDADC1 cytidine and dCMP deaminase domain containing 1
CDK3 cyclin-dependent kinase 3
CHPF chondroitin polymerizing factor
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CORT cortistatin
CPA4 carboxypeptidase A4
CTH cystathionine gamma-lyase
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DEAF1 DEAF1 transcription factor
DSPP dentin sialophosphoprotein
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ENO2 enolase 2 (gamma, neuronal)
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
EPHB6 EPH receptor B6
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMD1 FERM domain containing 1
FUZ fuzzy planar cell polarity protein
GAA glucosidase, alpha; acid
HIST1H2BI histone cluster 1, H2bi
HIST1H2BJ histone cluster 1, H2bj
HIST1H3G histone cluster 1, H3g
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JUNB jun B proto-oncogene
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM7A lysine (K)-specific demethylase 7A
KIAA1024 KIAA1024
KLF1 Kruppel-like factor 1 (erythroid)
LHFP lipoma HMGIC fusion partner
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LMBR1L limb development membrane protein 1-like
LMNB1 lamin B1
LOC157562 uncharacterized LOC157562
MAGEB2 melanoma antigen family B2
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEGF8 multiple EGF-like-domains 8
MON1B MON1 secretory trafficking family member B
MRAS muscle RAS oncogene homolog
MTA2 metastasis associated 1 family, member 2
MVD mevalonate (diphospho) decarboxylase
MYO15A myosin XVA
NACA2 nascent polypeptide-associated complex alpha subunit 2
NPIPB15 nuclear pore complex interacting protein family, member B15
PAQR4 progestin and adipoQ receptor family member IV
PAQR6 progestin and adipoQ receptor family member VI
PARP16 poly (ADP-ribose) polymerase family, member 16
PDE12 phosphodiesterase 12
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIPOX pipecolic acid oxidase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
POR P450 (cytochrome) oxidoreductase
PRAMEF11 PRAME family member 11
PRKCZ protein kinase C, zeta
PRY PTPN13-like, Y-linked
PYGB phosphorylase, glycogen; brain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS19 regulator of G-protein signaling 19
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RNF25 ring finger protein 25
SCGB2A2 secretoglobin, family 2A, member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SNRPN small nuclear ribonucleoprotein polypeptide N
STK25 serine/threonine kinase 25
SUGP1 SURP and G patch domain containing 1
TET3 tet methylcytosine dioxygenase 3
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMOD1 tropomodulin 1
TNNT1 troponin T type 1 (skeletal, slow)
TRIM9 tripartite motif containing 9
TRPS1 trichorhinophalangeal syndrome I
TSPYL2 TSPY-like 2
USP18 ubiquitin specific peptidase 18
USP6 ubiquitin specific peptidase 6
VSIG10 V-set and immunoglobulin domain containing 10
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB25 zinc finger and BTB domain containing 25
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF324 zinc finger protein 324
ZNF862 zinc finger protein 862