triprolidine-7248 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the triprolidine-7248 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASAP1-IT1 ASAP1 intronic transcript 1
ATF3 activating transcription factor 3
ATP9B ATPase, class II, type 9B
BAIAP2 BAI1-associated protein 2
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
C7ORF26 chromosome 7 open reading frame 26
CD82 CD82 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUSP1 dual specificity phosphatase 1
ELOVL4 ELOVL fatty acid elongase 4
ELSPBP1 epididymal sperm binding protein 1
EPN1 epsin 1
FGF2 fibroblast growth factor 2 (basic)
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD2A GATA zinc finger domain containing 2A
GPR176 G protein-coupled receptor 176
GPRC5B G protein-coupled receptor, class C, group 5, member B
GREM1 gremlin 1, DAN family BMP antagonist
HCFC1 host cell factor C1
HDAC7 histone deacetylase 7
HLX H2.0-like homeobox
IFI35 interferon-induced protein 35
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
INHBB inhibin, beta B
ISG15 ISG15 ubiquitin-like modifier
KIF2A kinesin heavy chain member 2A
KMT2A lysine (K)-specific methyltransferase 2A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC730101 uncharacterized LOC730101
LRRK1 leucine-rich repeat kinase 1
MBNL2 muscleblind-like splicing regulator 2
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NCOA3 nuclear receptor coactivator 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PAWR PRKC, apoptosis, WT1, regulator
PDE12 phosphodiesterase 12
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PHTF2 putative homeodomain transcription factor 2
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTX3 pentraxin 3, long
R3HDM4 R3H domain containing 4
RAP1GAP2 RAP1 GTPase activating protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIF1 replication timing regulatory factor 1
RPL35A ribosomal protein L35a
RPL7 ribosomal protein L7
RUNX1-IT1 RUNX1 intronic transcript 1
S100A11 S100 calcium binding protein A11
SCARB1 scavenger receptor class B, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT6 sirtuin 6
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOCS2 suppressor of cytokine signaling 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TAPBPL TAP binding protein-like
TGFB2 transforming growth factor, beta 2
TMEM183A transmembrane protein 183A
TOR1AIP1 torsin A interacting protein 1
TRIM23 tripartite motif containing 23
TSSK2 testis-specific serine kinase 2
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
TUFT1 tuftelin 1
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WWC1 WW and C2 domain containing 1
ZHX2 zinc fingers and homeoboxes 2
ZNF702P zinc finger protein 702, pseudogene
ZNF84 zinc finger protein 84

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ANKHD1 ankyrin repeat and KH domain containing 1
APH1B APH1B gamma secretase subunit
AUH AU RNA binding protein/enoyl-CoA hydratase
AXIN1 axin 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
CCRL2 chemokine (C-C motif) receptor-like 2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEMIP cell migration inducing protein, hyaluronan binding
CHKB choline kinase beta
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN15 claudin 15
COL4A5 collagen, type IV, alpha 5
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYBB2P1 crystallin, beta B2 pseudogene 1
DET1 de-etiolated homolog 1 (Arabidopsis)
EFCAB2 EF-hand calcium binding domain 2
EFTUD1 elongation factor Tu GTP binding domain containing 1
ELP3 elongator acetyltransferase complex subunit 3
EML4 echinoderm microtubule associated protein like 4
ERCC8 excision repair cross-complementation group 8
FBP1 fructose-1,6-bisphosphatase 1
FBXL2 F-box and leucine-rich repeat protein 2
FBXO46 F-box protein 46
FLRT3 fibronectin leucine rich transmembrane protein 3
FPGS folylpolyglutamate synthase
GLI3 GLI family zinc finger 3
GMIP GEM interacting protein
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR4 G protein-coupled receptor 4
GPR87 G protein-coupled receptor 87
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H3G histone cluster 1, H3g
HOXA4 homeobox A4
HYAL3 hyaluronoglucosaminidase 3
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIAA0895 KIAA0895
KRBOX4 KRAB box domain containing 4
LPAR3 lysophosphatidic acid receptor 3
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LXN latexin
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP6D1 MAP6 domain containing 1
MFGE8 milk fat globule-EGF factor 8 protein
MYL5 myosin, light chain 5, regulatory
NAG18 NAG18 mRNA
NPM3 nucleophosmin/nucleoplasmin 3
NTSR1 neurotensin receptor 1 (high affinity)
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PACS1 phosphofurin acidic cluster sorting protein 1
PALMD palmdelphin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHC1 polyhomeotic homolog 1 (Drosophila)
PID1 phosphotyrosine interaction domain containing 1
PLCD1 phospholipase C, delta 1
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RIPPLY3 ripply transcriptional repressor 3
RPL13P5 ribosomal protein L13 pseudogene 5
RPL23AP32 ribosomal protein L23a pseudogene 32
SATB1 SATB homeobox 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A8 solute carrier family 12, member 8
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMA4 glucuronidase, beta pseudogene
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK25 serine/threonine kinase 25
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYTL2 synaptotagmin-like 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TENM4 teneurin transmembrane protein 4
TESPA1 thymocyte expressed, positive selection associated 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM104 transmembrane protein 104
TMEM51 transmembrane protein 51
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TUBA1A tubulin, alpha 1a
UNKL unkempt family zinc finger-like
ZNF177 zinc finger protein 177
ZNF227 zinc finger protein 227
ZNF273 zinc finger protein 273
ZNF350 zinc finger protein 350
ZNF415 zinc finger protein 415
ZNF629 zinc finger protein 629
ZNF701 zinc finger protein 701
ZNF862 zinc finger protein 862
ZNHIT2 zinc finger, HIT-type containing 2
ZSCAN26 zinc finger and SCAN domain containing 26