trimipramine-4083 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trimipramine-4083 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOL3 apolipoprotein L, 3
AQP4 aquaporin 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASIC4 acid sensing (proton gated) ion channel family member 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
B9D2 B9 protein domain 2
BAIAP3 BAI1-associated protein 3
BATF basic leucine zipper transcription factor, ATF-like
C11ORF16 chromosome 11 open reading frame 16
CACNG5 calcium channel, voltage-dependent, gamma subunit 5
CCNG2 cyclin G2
CD209 CD209 molecule
CD6 CD6 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMP1 cementum protein 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN6 chloride channel, voltage-sensitive 6
CLDN1 claudin 1
COL14A1 collagen, type XIV, alpha 1
CRHR2 corticotropin releasing hormone receptor 2
CSF1R colony stimulating factor 1 receptor
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DOK2 docking protein 2, 56kDa
EFR3B EFR3 homolog B (S. cerevisiae)
ETV6 ets variant 6
EVX1 even-skipped homeobox 1
FGF18 fibroblast growth factor 18
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GK glycerol kinase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNMT histamine N-methyltransferase
HOXD13 homeobox D13
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IL12B interleukin 12B
IL6 interleukin 6
IZUMO4 IZUMO family member 4
JAG1 jagged 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNIP2 Kv channel interacting protein 2
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
LINC00341 long intergenic non-protein coding RNA 341
LPL lipoprotein lipase
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
METTL7A methyltransferase like 7A
MLANA melan-A
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NHLH2 nescient helix loop helix 2
NMUR1 neuromedin U receptor 1
NPC1 Niemann-Pick disease, type C1
NPR1 natriuretic peptide receptor 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAX5 paired box 5
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEKHS1 pleckstrin homology domain containing, family S member 1
PML promyelocytic leukemia
PNPLA2 patatin-like phospholipase domain containing 2
POU5F1B POU class 5 homeobox 1B
PPARD peroxisome proliferator-activated receptor delta
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RIF1 replication timing regulatory factor 1
RRAD Ras-related associated with diabetes
SARM1 sterile alpha and TIR motif containing 1
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC17A2 solute carrier family 17, member 2
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOS2 son of sevenless homolog 2 (Drosophila)
SOX21 SRY (sex determining region Y)-box 21
SPX spexin hormone
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STX3 syntaxin 3
SUGP1 SURP and G patch domain containing 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TAAR5 trace amine associated receptor 5
TBX2 T-box 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TMEM206 transmembrane protein 206
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TTLL1 tubulin tyrosine ligase-like family member 1
VAX2 ventral anterior homeobox 2
ZBTB20 zinc finger and BTB domain containing 20
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
AEN apoptosis enhancing nuclease
AMDHD2 amidohydrolase domain containing 2
ANP32A-IT1 ANP32A intronic transcript 1
ANXA10 annexin A10
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARR3 arrestin 3, retinal (X-arrestin)
ARRB2 arrestin, beta 2
ARSJ arylsulfatase family, member J
ASB6 ankyrin repeat and SOCS box containing 6
AXIN1 axin 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCL2L2 BCL2-like 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CAMKMT calmodulin-lysine N-methyltransferase
CCDC85C coiled-coil domain containing 85C
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD3EAP CD3e molecule, epsilon associated protein
CD79B CD79b molecule, immunoglobulin-associated beta
CENPO centromere protein O
CHMP6 charged multivesicular body protein 6
CNN1 calponin 1, basic, smooth muscle
CUZD1 CUB and zona pellucida-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXORF21 chromosome X open reading frame 21
DHRS11 dehydrogenase/reductase (SDR family) member 11
E2F8 E2F transcription factor 8
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EVPL envoplakin
FAM86C1 family with sequence similarity 86, member C1
FBXO2 F-box protein 2
FGL1 fibrinogen-like 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD1C GRAM domain containing 1C
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H3F histone cluster 1, H3f
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KRT6A keratin 6A, type II
KRT86 keratin 86, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMO7 LIM domain 7
LOC257152 uncharacterized LOC257152
LRP4 low density lipoprotein receptor-related protein 4
LYPD1 LY6/PLAUR domain containing 1
LZTR1 leucine-zipper-like transcription regulator 1
MFSD6 major facilitator superfamily domain containing 6
MGC12488
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLYCD malonyl-CoA decarboxylase
MMP9 matrix metallopeptidase 9
MPP1 membrane protein, palmitoylated 1, 55kDa
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTCP1 mature T-cell proliferation 1
MUC3A mucin 3A, cell surface associated
NOTCH1 notch 1
NPFFR1 neuropeptide FF receptor 1
NT5DC3 5'-nucleotidase domain containing 3
PADI1 peptidyl arginine deiminase, type I
PALMD palmdelphin
PLBD1 phospholipase B domain containing 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POM121 POM121 transmembrane nucleoporin
PPAP2B phosphatidic acid phosphatase type 2B
PRR15L proline rich 15-like
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAYSD1 SAYSVFN motif domain containing 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDF2 stromal cell-derived factor 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLITRK5 SLIT and NTRK-like family, member 5
SLN sarcolipin
SP140L SP140 nuclear body protein-like
SSTR4 somatostatin receptor 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STEAP4 STEAP family member 4
TUBA3C tubulin, alpha 3c
TUBG2 tubulin, gamma 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WDR18 WD repeat domain 18
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB6 zinc finger and BTB domain containing 6
ZNF268 zinc finger protein 268
ZNF528 zinc finger protein 528
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768
ZW10 zw10 kinetochore protein