trimipramine-3004 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the trimipramine-3004 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ANO1 anoctamin 1, calcium activated chloride channel
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASB1 ankyrin repeat and SOCS box containing 1
AXL AXL receptor tyrosine kinase
CA6 carbonic anhydrase VI
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC186 coiled-coil domain containing 186
CCSER2 coiled-coil serine-rich protein 2
CDH10 cadherin 10, type 2 (T2-cadherin)
CDK19 cyclin-dependent kinase 19
CHMP6 charged multivesicular body protein 6
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRMP1 collapsin response mediator protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DGKE diacylglycerol kinase, epsilon 64kDa
DUSP4 dual specificity phosphatase 4
EGLN3 egl-9 family hypoxia-inducible factor 3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENDOD1 endonuclease domain containing 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FGF22 fibroblast growth factor 22
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GK3P glycerol kinase 3 pseudogene
GLP1R glucagon-like peptide 1 receptor
GRIK1 glutamate receptor, ionotropic, kainate 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIPK3 homeodomain interacting protein kinase 3
HIST1H2BC histone cluster 1, H2bc
HLA-F major histocompatibility complex, class I, F
INCENP inner centromere protein antigens 135/155kDa
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KMT2A lysine (K)-specific methyltransferase 2A
KRIT1 KRIT1, ankyrin repeat containing
KRT23 keratin 23, type I
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
MCM3AP minichromosome maintenance complex component 3 associated protein
MED15 mediator complex subunit 15
MLXIP MLX interacting protein
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NCOR2 nuclear receptor corepressor 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLRP1 NLR family, pyrin domain containing 1
NMT1 N-myristoyltransferase 1
NUCB1 nucleobindin 1
OLFM1 olfactomedin 1
OLIG2 oligodendrocyte lineage transcription factor 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAX5 paired box 5
PBX2 pre-B-cell leukemia homeobox 2
PCGF2 polycomb group ring finger 2
PDE4DIP phosphodiesterase 4D interacting protein
PDX1 pancreatic and duodenal homeobox 1
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PORCN porcupine homolog (Drosophila)
PRLR prolactin receptor
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGIS prostaglandin I2 (prostacyclin) synthase
QKI QKI, KH domain containing, RNA binding
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RDX radixin
RGS1 regulator of G-protein signaling 1
RNGTT RNA guanylyltransferase and 5'-phosphatase
RRBP1 ribosome binding protein 1
SFN stratifin
SLAMF7 SLAM family member 7
SLC12A8 solute carrier family 12, member 8
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMAD1 SMAD family member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX13 sorting nexin 13
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
TLK1 tousled-like kinase 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TPM3 tropomyosin 3
TPST1 tyrosylprotein sulfotransferase 1
TRIM49 tripartite motif containing 49
TRIP11 thyroid hormone receptor interactor 11
TRPS1 trichorhinophalangeal syndrome I
TUBA4B tubulin, alpha 4b
USP46 ubiquitin specific peptidase 46
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZNF500 zinc finger protein 500
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AIM2 absent in melanoma 2
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANO2 anoctamin 2, calcium activated chloride channel
APOC4 apolipoprotein C-IV
ARMCX4 armadillo repeat containing, X-linked 4
BEST1 bestrophin 1
C1ORF159 chromosome 1 open reading frame 159
C3ORF14 chromosome 3 open reading frame 14
C5ORF45 chromosome 5 open reading frame 45
C8A complement component 8, alpha polypeptide
CABP2 calcium binding protein 2
CASS4 Cas scaffolding protein family member 4
CCDC71 coiled-coil domain containing 71
CDHR2 cadherin-related family member 2
CDK20 cyclin-dependent kinase 20
CELP carboxyl ester lipase pseudogene
CENPO centromere protein O
CLDN3 claudin 3
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
DDN dendrin
DSPP dentin sialophosphoprotein
EBF2 early B-cell factor 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM102A family with sequence similarity 102, member A
FAM106A family with sequence similarity 106, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXO40 F-box protein 40
FGF23 fibroblast growth factor 23
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GBP2 guanylate binding protein 2, interferon-inducible
GPC3 glypican 3
GPR35 G protein-coupled receptor 35
GRPR gastrin-releasing peptide receptor
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HDAC7 histone deacetylase 7
HIST1H2AI histone cluster 1, H2ai
HOXB9 homeobox B9
HOXC10 homeobox C10
HOXD10 homeobox D10
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
JAM3 junctional adhesion molecule 3
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRT12 keratin 12, type I
LEFTY2 left-right determination factor 2
LOC100286895 cell division cycle 27 homolog pseudogene
LTBP2 latent transforming growth factor beta binding protein 2
LY6D lymphocyte antigen 6 complex, locus D
MAGEF1 melanoma antigen family F1
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYH4 myosin, heavy chain 4, skeletal muscle
NCS1 neuronal calcium sensor 1
NMUR1 neuromedin U receptor 1
NOL12 nucleolar protein 12
NPPB natriuretic peptide B
OSBP2 oxysterol binding protein 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PBOV1 prostate and breast cancer overexpressed 1
PCBP4 poly(rC) binding protein 4
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRB3 proline-rich protein BstNI subfamily 3
PRO2964 uncharacterized protein PRO2964
PRR4 proline rich 4 (lacrimal)
PTPRS protein tyrosine phosphatase, receptor type, S
RAB3A RAB3A, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM12B-AS1 RBM12B antisense RNA 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SCRT1 scratch family zinc finger 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFRP5 secreted frizzled-related protein 5
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
STX1A syntaxin 1A (brain)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCHH trichohyalin
TIAM2 T-cell lymphoma invasion and metastasis 2
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM212 transmembrane protein 212
TNNT1 troponin T type 1 (skeletal, slow)
TPSB2 tryptase beta 2 (gene/pseudogene)
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTLL1 tubulin tyrosine ligase-like family member 1
WASF3 WAS protein family, member 3
ZNF134 zinc finger protein 134
ZNF280A zinc finger protein 280A
ZNF484 zinc finger protein 484