trimethylcolchicinic acid-4202 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the trimethylcolchicinic acid-4202 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOT11 acyl-CoA thioesterase 11
ACVR1B activin A receptor, type IB
ADCY10 adenylate cyclase 10 (soluble)
ALK anaplastic lymphoma receptor tyrosine kinase
ANKH ANKH inorganic pyrophosphate transport regulator
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APC adenomatous polyposis coli
APLP2 amyloid beta (A4) precursor-like protein 2
ASPN asporin
BAGE B melanoma antigen
BATF basic leucine zipper transcription factor, ATF-like
C14ORF93 chromosome 14 open reading frame 93
C17ORF70 chromosome 17 open reading frame 70
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC28B coiled-coil domain containing 28B
CCDC71 coiled-coil domain containing 71
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
ELOVL2 ELOVL fatty acid elongase 2
ERO1LB ERO1-like beta (S. cerevisiae)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FKBP10 FK506 binding protein 10, 65 kDa
FN1 fibronectin 1
FRZB frizzled-related protein
FSCN3 fascin actin-bundling protein 3, testicular
GAL3ST4 galactose-3-O-sulfotransferase 4
GK3P glycerol kinase 3 pseudogene
GOLGA2 golgin A2
GOLGA6A golgin A6 family, member A
GPR21 G protein-coupled receptor 21
HAP1 huntingtin-associated protein 1
HBB hemoglobin, beta
HEATR6 HEAT repeat containing 6
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOMER3 homer scaffolding protein 3
HSF2BP heat shock transcription factor 2 binding protein
IL18R1 interleukin 18 receptor 1
INPP5J inositol polyphosphate-5-phosphatase J
IQCK IQ motif containing K
KRT7 keratin 7, type II
LEF1 lymphoid enhancer-binding factor 1
LRP1 low density lipoprotein receptor-related protein 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGEA5 melanoma antigen family A5
MEF2D myocyte enhancer factor 2D
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MUC3A mucin 3A, cell surface associated
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NF1 neurofibromin 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NUDC nudC nuclear distribution protein
OSGIN2 oxidative stress induced growth inhibitor family member 2
PALMD palmdelphin
PAWR PRKC, apoptosis, WT1, regulator
PDLIM3 PDZ and LIM domain 3
PDLIM5 PDZ and LIM domain 5
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PHF20L1 PHD finger protein 20-like 1
PKN2 protein kinase N2
PTGDR2 prostaglandin D2 receptor 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PVR poliovirus receptor
QPCTL glutaminyl-peptide cyclotransferase-like
RAB36 RAB36, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1 retinoblastoma 1
RBFA ribosome binding factor A (putative)
RBMS3 RNA binding motif, single stranded interacting protein 3
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RHEB Ras homolog enriched in brain
RPS14 ribosomal protein S14
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SMO smoothened, frizzled class receptor
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTBN1 spectrin, beta, non-erythrocytic 1
TDO2 tryptophan 2,3-dioxygenase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIK TRAF2 and NCK interacting kinase
TWF1 twinfilin actin binding protein 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WSB1 WD repeat and SOCS box containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF589 zinc finger protein 589
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ADAM2 ADAM metallopeptidase domain 2
ADAM23 ADAM metallopeptidase domain 23
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
C14ORF105 chromosome 14 open reading frame 105
C16ORF45 chromosome 16 open reading frame 45
C22ORF46 chromosome 22 open reading frame 46
C8A complement component 8, alpha polypeptide
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CLDN1 claudin 1
CLEC16A C-type lectin domain family 16, member A
CLTCL1 clathrin, heavy chain-like 1
CNN1 calponin 1, basic, smooth muscle
CORO1A coronin, actin binding protein, 1A
CPPED1 calcineurin-like phosphoesterase domain containing 1
DNAL4 dynein, axonemal, light chain 4
ELP6 elongator acetyltransferase complex subunit 6
ERN2 endoplasmic reticulum to nucleus signaling 2
FRMPD1 FERM and PDZ domain containing 1
GMPR guanosine monophosphate reductase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HDAC5 histone deacetylase 5
HIST1H2AI histone cluster 1, H2ai
HIST1H2AK histone cluster 1, H2ak
HIST1H3F histone cluster 1, H3f
ICOS inducible T-cell co-stimulator
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFT140 intraflagellar transport 140
IL15RA interleukin 15 receptor, alpha
ITGB7 integrin, beta 7
JUNB jun B proto-oncogene
KANSL3 KAT8 regulatory NSL complex subunit 3
KDM5C lysine (K)-specific demethylase 5C
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
LOC157562 uncharacterized LOC157562
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MED9 mediator complex subunit 9
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MNX1 motor neuron and pancreas homeobox 1
MRPL41 mitochondrial ribosomal protein L41
MTCP1 mature T-cell proliferation 1
MTSS1L metastasis suppressor 1-like
MXD3 MAX dimerization protein 3
MYO1F myosin IF
NACA2 nascent polypeptide-associated complex alpha subunit 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PCDH12 protocadherin 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLBD1 phospholipase B domain containing 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRSS53 protease, serine, 53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
RGCC regulator of cell cycle
RNF39 ring finger protein 39
S1PR1 sphingosine-1-phosphate receptor 1
SAYSD1 SAYSVFN motif domain containing 1
SCG2 secretogranin II
SDAD1 SDA1 domain containing 1
SENP7 SUMO1/sentrin specific peptidase 7
SERGEF secretion regulating guanine nucleotide exchange factor
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SMAD7 SMAD family member 7
SOX12 SRY (sex determining region Y)-box 12
SOX21 SRY (sex determining region Y)-box 21
SPTBN2 spectrin, beta, non-erythrocytic 2
SUGCT succinyl-CoA:glutarate-CoA transferase
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBKBP1 TBK1 binding protein 1
TESPA1 thymocyte expressed, positive selection associated 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLN1 talin 1
TMPRSS4 transmembrane protease, serine 4
TRABD TraB domain containing
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPAN2 tetraspanin 2
UGT8 UDP glycosyltransferase 8
USP20 ubiquitin specific peptidase 20
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
XAB2 XPA binding protein 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB6 zinc finger and BTB domain containing 6
ZNF286A zinc finger protein 286A