trimethoprim-4701 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the trimethoprim-4701 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK4 aarF domain containing kinase 4
ADM adrenomedullin
AHNAK AHNAK nucleoprotein
AKAP6 A kinase (PRKA) anchor protein 6
AMACR alpha-methylacyl-CoA racemase
ANGEL2 angel homolog 2 (Drosophila)
ANGPT4 angiopoietin 4
AQP3 aquaporin 3 (Gill blood group)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB1 arrestin, beta 1
ARTN artemin
BIRC3 baculoviral IAP repeat containing 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C11ORF63 chromosome 11 open reading frame 63
C1ORF105 chromosome 1 open reading frame 105
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CD34 CD34 molecule
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFAP45 cilia and flagella associated protein 45
CFAP69 cilia and flagella associated protein 69
CLCF1 cardiotrophin-like cytokine factor 1
CNTNAP2 contactin associated protein-like 2
CREB1 cAMP responsive element binding protein 1
CSPP1 centrosome and spindle pole associated protein 1
CYHR1 cysteine/histidine-rich 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DGKE diacylglycerol kinase, epsilon 64kDa
DIXDC1 DIX domain containing 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELOVL2 ELOVL fatty acid elongase 2
EPS8L1 EPS8-like 1
FANCA Fanconi anemia, complementation group A
FBXO21 F-box protein 21
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR3 fibroblast growth factor receptor 3
FMOD fibromodulin
FUS FUS RNA binding protein
GBP2 guanylate binding protein 2, interferon-inducible
GDAP1 ganglioside induced differentiation associated protein 1
GLRX3 glutaredoxin 3
GOLGA8B golgin A8 family, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMG20B high mobility group 20B
HRASLS2 HRAS-like suppressor 2
HSPG2 heparan sulfate proteoglycan 2
ICOSLG inducible T-cell co-stimulator ligand
IGHMBP2 immunoglobulin mu binding protein 2
INCENP inner centromere protein antigens 135/155kDa
ING4 inhibitor of growth family, member 4
INHBA inhibin, beta A
ITPK1 inositol-tetrakisphosphate 1-kinase
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP1 Kv channel interacting protein 1
KIAA0040 KIAA0040
LSP1 lymphocyte-specific protein 1
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MED31 mediator complex subunit 31
NDRG2 NDRG family member 2
OTUD4 OTU deubiquitinase 4
PCDHA6 protocadherin alpha 6
PDE3B phosphodiesterase 3B, cGMP-inhibited
PGR progesterone receptor
PHLDB1 pleckstrin homology-like domain, family B, member 1
PKN1 protein kinase N1
PLAU plasminogen activator, urokinase
PLD2 phospholipase D2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNA1 plexin A1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKCE protein kinase C, epsilon
PSG6 pregnancy specific beta-1-glycoprotein 6
QKI QKI, KH domain containing, RNA binding
RAB6A RAB6A, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCAND2P SCAN domain containing 2 pseudogene
SIPA1 signal-induced proliferation-associated 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRED2 sprouty-related, EVH1 domain containing 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
THRAP3 thyroid hormone receptor associated protein 3
TLDC1 TBC/LysM-associated domain containing 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
UBE3B ubiquitin protein ligase E3B
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VGF VGF nerve growth factor inducible
ZC3H7B zinc finger CCCH-type containing 7B
ZIC3 Zic family member 3
ZNF286A zinc finger protein 286A
ZNF318 zinc finger protein 318
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ARHGAP4 Rho GTPase activating protein 4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP11B ATPase, class VI, type 11B
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAG4 BCL2-associated athanogene 4
BFSP1 beaded filament structural protein 1, filensin
BHLHE41 basic helix-loop-helix family, member e41
C2ORF27A chromosome 2 open reading frame 27A
CADPS2 Ca++-dependent secretion activator 2
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPG capping protein (actin filament), gelsolin-like
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CEL carboxyl ester lipase
CGREF1 cell growth regulator with EF-hand domain 1
CIDEB cell death-inducing DFFA-like effector b
CLCN6 chloride channel, voltage-sensitive 6
CNR2 cannabinoid receptor 2 (macrophage)
CORT cortistatin
CSF1R colony stimulating factor 1 receptor
DEAF1 DEAF1 transcription factor
DTX2 deltex 2, E3 ubiquitin ligase
EGFL7 EGF-like-domain, multiple 7
EHD3 EH-domain containing 3
EIF5A2 eukaryotic translation initiation factor 5A2
ELSPBP1 epididymal sperm binding protein 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO5 exonuclease 5
FAM188A family with sequence similarity 188, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO31 F-box protein 31
FLJ21369 uncharacterized protein FLJ21369
GLRA1 glycine receptor, alpha 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HDAC11 histone deacetylase 11
IFT140 intraflagellar transport 140
IMPACT impact RWD domain protein
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KDM8 lysine (K)-specific demethylase 8
KLK5 kallikrein-related peptidase 5
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT31 keratin 31, type I
KRT86 keratin 86, type II
LARP6 La ribonucleoprotein domain family, member 6
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
NAT6 N-acetyltransferase 6 (GCN5-related)
NEUROD1 neuronal differentiation 1
NEUROD4 neuronal differentiation 4
NOL10 nucleolar protein 10
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAIP2B poly(A) binding protein interacting protein 2B
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PELI1 pellino E3 ubiquitin protein ligase 1
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLAT plasminogen activator, tissue
PMEL premelanosome protein
POMT2 protein-O-mannosyltransferase 2
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRR4 proline rich 4 (lacrimal)
PTPRS protein tyrosine phosphatase, receptor type, S
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS19 regulator of G-protein signaling 19
RIN1 Ras and Rab interactor 1
SAA3P serum amyloid A3 pseudogene
SAMD9 sterile alpha motif domain containing 9
SDC3 syndecan 3
SF3A2 splicing factor 3a, subunit 2, 66kDa
SKI SKI proto-oncogene
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TEP1 telomerase-associated protein 1
TIGD6 tigger transposable element derived 6
TMEM212 transmembrane protein 212
TRAIP TRAF interacting protein
TRAPPC2 trafficking protein particle complex 2
TRPC5 transient receptor potential cation channel, subfamily C, member 5
UBQLN4 ubiquilin 4
UPK2 uroplakin 2
VASH1 vasohibin 1
VEGFB vascular endothelial growth factor B
ZFHX3 zinc finger homeobox 3
ZFP69B ZFP69 zinc finger protein B
ZNF446 zinc finger protein 446
ZNF652 zinc finger protein 652
ZNF701 zinc finger protein 701