trimethadione-4086 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the trimethadione-4086 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACTN2 actinin, alpha 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
ALDOB aldolase B, fructose-bisphosphate
ANKH ANKH inorganic pyrophosphate transport regulator
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APOA4 apolipoprotein A-IV
APOE apolipoprotein E
ARHGAP26 Rho GTPase activating protein 26
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC64 coiled-coil domain containing 64
CEP152 centrosomal protein 152kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL3A1 collagen, type III, alpha 1
COMT catechol-O-methyltransferase
CTSS cathepsin S
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
DRICH1 aspartate-rich 1
DSG3 desmoglein 3
DTNA dystrobrevin, alpha
EML2 echinoderm microtubule associated protein like 2
FAM174B family with sequence similarity 174, member B
FBXO40 F-box protein 40
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXF1 forkhead box F1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GPR17 G protein-coupled receptor 17
GUCA1B guanylate cyclase activator 1B (retina)
HAL histidine ammonia-lyase
HBS1L HBS1-like translational GTPase
HOXD13 homeobox D13
IGFBP7 insulin-like growth factor binding protein 7
KCNK10 potassium channel, two pore domain subfamily K, member 10
KLK10 kallikrein-related peptidase 10
KLK7 kallikrein-related peptidase 7
LDB3 LIM domain binding 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK11 mitogen-activated protein kinase 11
MEFV Mediterranean fever
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MYL10 myosin, light chain 10, regulatory
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYO1B myosin IB
NF1 neurofibromin 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OR3A3 olfactory receptor, family 3, subfamily A, member 3
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PALM paralemmin
PAOX polyamine oxidase (exo-N4-amino)
PBX1 pre-B-cell leukemia homeobox 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDE4B phosphodiesterase 4B, cAMP-specific
PGAP3 post-GPI attachment to proteins 3
PHF3 PHD finger protein 3
PLA2G5 phospholipase A2, group V
PLCD1 phospholipase C, delta 1
PMS2P4 postmeiotic segregation increased 2 pseudogene 4
POM121L2 POM121 transmembrane nucleoporin-like 2
PPAP2C phosphatidic acid phosphatase type 2C
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYY peptide YY
RASAL2 RAS protein activator like 2
RB1 retinoblastoma 1
RDH16 retinol dehydrogenase 16 (all-trans)
RIMS3 regulating synaptic membrane exocytosis 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF43 ring finger protein 43
RPL13 ribosomal protein L13
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCAPER S-phase cyclin A-associated protein in the ER
SERHL2 serine hydrolase-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SOCS3 suppressor of cytokine signaling 3
SRSF7 serine/arginine-rich splicing factor 7
SUGP1 SURP and G patch domain containing 1
SYT12 synaptotagmin XII
TEX13A testis expressed 13A
TEX15 testis expressed 15
TFCP2L1 transcription factor CP2-like 1
TFEB transcription factor EB
TMPRSS3 transmembrane protease, serine 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRA T cell receptor alpha locus
TRPM1 transient receptor potential cation channel, subfamily M, member 1
UST uronyl-2-sulfotransferase
VWA5A von Willebrand factor A domain containing 5A

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACE angiotensin I converting enzyme
ACYP2 acylphosphatase 2, muscle type
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANP32A-IT1 ANP32A intronic transcript 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARR3 arrestin 3, retinal (X-arrestin)
ATAT1 alpha tubulin acetyltransferase 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BAGE B melanoma antigen
BTF3P12 basic transcription factor 3 pseudogene 12
CAPN15 calpain 15
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD82 CD82 molecule
CGA glycoprotein hormones, alpha polypeptide
CGREF1 cell growth regulator with EF-hand domain 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTFR ciliary neurotrophic factor receptor
CXORF21 chromosome X open reading frame 21
DAGLA diacylglycerol lipase, alpha
DDN dendrin
DENND2D DENN/MADD domain containing 2D
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNM3 dynamin 3
DSPP dentin sialophosphoprotein
EFCAB2 EF-hand calcium binding domain 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO5 exonuclease 5
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
GAS8 growth arrest-specific 8
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPATCH2L G patch domain containing 2-like
GPC3 glypican 3
GRTP1 growth hormone regulated TBC protein 1
HIST1H3F histone cluster 1, H3f
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFNA17 interferon, alpha 17
IPO8 importin 8
KDM8 lysine (K)-specific demethylase 8
KLF1 Kruppel-like factor 1 (erythroid)
LIME1 Lck interacting transmembrane adaptor 1
LMO7 LIM domain 7
LOXL3 lysyl oxidase-like 3
LY86 lymphocyte antigen 86
MAL mal, T-cell differentiation protein
MGP matrix Gla protein
MTA2 metastasis associated 1 family, member 2
MTCP1 mature T-cell proliferation 1
MTSS1L metastasis suppressor 1-like
MYO1F myosin IF
NEUROD4 neuronal differentiation 4
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NOL4 nucleolar protein 4
NPIPB15 nuclear pore complex interacting protein family, member B15
NPVF neuropeptide VF precursor
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
OSMR oncostatin M receptor
PAX9 paired box 9
PLA2G1B phospholipase A2, group IB (pancreas)
PLBD1 phospholipase B domain containing 1
PLD3 phospholipase D family, member 3
PODXL2 podocalyxin-like 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR15L proline rich 15-like
QPCTL glutaminyl-peptide cyclotransferase-like
QSER1 glutamine and serine rich 1
RAB40A RAB40A, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFPL1S RFPL1 antisense RNA 1
SAMD9 sterile alpha motif domain containing 9
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SNTA1 syntrophin, alpha 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TFDP3 transcription factor Dp family, member 3
THRB thyroid hormone receptor, beta
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM212 transmembrane protein 212
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TUBA4B tubulin, alpha 4b
USP20 ubiquitin specific peptidase 20
VNN1 vanin 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMAT5 zinc finger, matrin-type 5
ZNF37BP zinc finger protein 37B, pseudogene
ZNF862 zinc finger protein 862