trihexyphenidyl-4133 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trihexyphenidyl-4133 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADAM22 ADAM metallopeptidase domain 22
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
ALOX5 arachidonate 5-lipoxygenase
ATF3 activating transcription factor 3
ATG13 autophagy related 13
ATN1 atrophin 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BMP8A bone morphogenetic protein 8a
C18ORF25 chromosome 18 open reading frame 25
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CARD9 caspase recruitment domain family, member 9
CAV3 caveolin 3
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC14A cell division cycle 14A
CLCN6 chloride channel, voltage-sensitive 6
CLDN11 claudin 11
CLTA clathrin, light chain A
COBLL1 cordon-bleu WH2 repeat protein-like 1
CRISP2 cysteine-rich secretory protein 2
CTAGE5 CTAGE family, member 5
CTGF connective tissue growth factor
DAPK3 death-associated protein kinase 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOCK10 dedicator of cytokinesis 10
EGR1 early growth response 1
FAM129A family with sequence similarity 129, member A
FAM182B family with sequence similarity 182, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR85 G protein-coupled receptor 85
GRIK5 glutamate receptor, ionotropic, kainate 5
GSTM5 glutathione S-transferase mu 5
HIF3A hypoxia inducible factor 3, alpha subunit
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXA11 homeobox A11
HSPG2 heparan sulfate proteoglycan 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGSF6 immunoglobulin superfamily, member 6
ING2 inhibitor of growth family, member 2
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF25-AS1 KIF25 antisense RNA 1
KLF2 Kruppel-like factor 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2D myocyte enhancer factor 2D
METTL16 methyltransferase like 16
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MOGAT2 monoacylglycerol O-acyltransferase 2
MUC3B mucin 3B, cell surface associated
MXD4 MAX dimerization protein 4
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEU3 sialidase 3 (membrane sialidase)
NF1 neurofibromin 1
NTS neurotensin
OR7A17 olfactory receptor, family 7, subfamily A, member 17
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PLSCR3 phospholipid scramblase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2F2 POU class 2 homeobox 2
RGS10 regulator of G-protein signaling 10
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RORC RAR-related orphan receptor C
SASH3 SAM and SH3 domain containing 3
SCN5A sodium channel, voltage gated, type V alpha subunit
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC35G2 solute carrier family 35, member G2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SSPN sarcospan
SYNJ1 synaptojanin 1
SYT2 synaptotagmin II
TEX14 testis expressed 14
TGFB2 transforming growth factor, beta 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOR4A torsin family 4, member A
TRIM3 tripartite motif containing 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WNT10B wingless-type MMTV integration site family, member 10B
ZNF155 zinc finger protein 155
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADGRG2 adhesion G protein-coupled receptor G2
ASIC3 acid sensing (proton gated) ion channel 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAHCC1 BAH domain and coiled-coil containing 1
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C2ORF27A chromosome 2 open reading frame 27A
C5AR1 complement component 5a receptor 1
C7ORF69 chromosome 7 open reading frame 69
CD53 CD53 molecule
CEP131 centrosomal protein 131kDa
CLCN5 chloride channel, voltage-sensitive 5
CNGB3 cyclic nucleotide gated channel beta 3
CORT cortistatin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRMP1 collapsin response mediator protein 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DENND5B DENN/MADD domain containing 5B
DNAL4 dynein, axonemal, light chain 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
EN2 engrailed homeobox 2
ERCC2 excision repair cross-complementation group 2
EVPL envoplakin
EXOC6B exocyst complex component 6B
FAAH fatty acid amide hydrolase
FBXL6 F-box and leucine-rich repeat protein 6
FBXL8 F-box and leucine-rich repeat protein 8
FBXO31 F-box protein 31
GAMT guanidinoacetate N-methyltransferase
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HIST1H4A histone cluster 1, H4a
HP1BP3 heterochromatin protein 1, binding protein 3
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IL11RA interleukin 11 receptor, alpha
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KIAA0754 KIAA0754
KLF1 Kruppel-like factor 1 (erythroid)
KLHL25 kelch-like family member 25
KRT83 keratin 83, type II
LEFTY1 left-right determination factor 1
LTC4S leukotriene C4 synthase
MAPK10 mitogen-activated protein kinase 10
MOCS3 molybdenum cofactor synthesis 3
MVD mevalonate (diphospho) decarboxylase
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NDRG4 NDRG family member 4
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPY4R neuropeptide Y receptor Y4
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGP phosphoglycolate phosphatase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMEL premelanosome protein
POLH polymerase (DNA directed), eta
PORCN porcupine homolog (Drosophila)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PROL1 proline rich, lacrimal 1
PTPRM protein tyrosine phosphatase, receptor type, M
RAB3D RAB3D, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNF122 ring finger protein 122
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPUSD2 RNA pseudouridylate synthase domain containing 2
S100A2 S100 calcium binding protein A2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A6 solute carrier family 16, member 6
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPTBN2 spectrin, beta, non-erythrocytic 2
STAB2 stabilin 2
TAOK1 TAO kinase 1
TEP1 telomerase-associated protein 1
TEX40 testis expressed 40
TLR5 toll-like receptor 5
TM4SF4 transmembrane 4 L six family member 4
TNS2 tensin 2
TRAIP TRAF interacting protein
TSNAXIP1 translin-associated factor X interacting protein 1
TTLL1 tubulin tyrosine ligase-like family member 1
UNC119 unc-119 homolog (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
XYLT2 xylosyltransferase II
ZBTB44 zinc finger and BTB domain containing 44
ZNF37BP zinc finger protein 37B, pseudogene
ZNF41 zinc finger protein 41