triflupromazine-7466 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the triflupromazine-7466 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AKT2 v-akt murine thymoma viral oncogene homolog 2
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
B9D2 B9 protein domain 2
BAIAP3 BAI1-associated protein 3
C14ORF132 chromosome 14 open reading frame 132
C17ORF59 chromosome 17 open reading frame 59
C5ORF45 chromosome 5 open reading frame 45
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CC2D1A coiled-coil and C2 domain containing 1A
CCDC121 coiled-coil domain containing 121
COL1A1 collagen, type I, alpha 1
COPZ2 coatomer protein complex, subunit zeta 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPK2 death-associated protein kinase 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
F11R F11 receptor
FAM65A family with sequence similarity 65, member A
FAS Fas cell surface death receptor
FGF12 fibroblast growth factor 12
FHL1 four and a half LIM domains 1
GLRX glutaredoxin (thioltransferase)
GSTCD glutathione S-transferase, C-terminal domain containing
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LOC257152 uncharacterized LOC257152
LPIN1 lipin 1
LRRC8E leucine rich repeat containing 8 family, member E
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP9 microtubule-associated protein 9
MFAP3L microfibrillar-associated protein 3-like
MPDZ multiple PDZ domain protein
MRPS12 mitochondrial ribosomal protein S12
MVK mevalonate kinase
NEURL1 neuralized E3 ubiquitin protein ligase 1
NF2 neurofibromin 2 (merlin)
NIPAL2 NIPA-like domain containing 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G3 phospholipase A2, group III
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARA retinoic acid receptor, alpha
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A8 S100 calcium binding protein A8
SCAPER S-phase cyclin A-associated protein in the ER
SCARB1 scavenger receptor class B, member 1
SIRT3 sirtuin 3
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SP100 SP100 nuclear antigen
SRR serine racemase
STX1A syntaxin 1A (brain)
SUGP1 SURP and G patch domain containing 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBXA2R thromboxane A2 receptor
TEP1 telomerase-associated protein 1
TESK1 testis-specific kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THBS3 thrombospondin 3
TMEM2 transmembrane protein 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTLL3 tubulin tyrosine ligase-like family member 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VASH2 vasohibin 2
VPS9D1 VPS9 domain containing 1
WWC1 WW and C2 domain containing 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBED1 zinc finger, BED-type containing 1
ZNF211 zinc finger protein 211
ZNF44 zinc finger protein 44
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AEN apoptosis enhancing nuclease
ALS2CL ALS2 C-terminal like
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APH1A APH1A gamma secretase subunit
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATRN attractin
BAHD1 bromo adjacent homology domain containing 1
BCL9 B-cell CLL/lymphoma 9
C11ORF30 chromosome 11 open reading frame 30
C21ORF91 chromosome 21 open reading frame 91
C7ORF43 chromosome 7 open reading frame 43
C9ORF40 chromosome 9 open reading frame 40
CAPRIN2 caprin family member 2
CD82 CD82 molecule
CEP85 centrosomal protein 85kDa
CFAP44 cilia and flagella associated protein 44
CHML choroideremia-like (Rab escort protein 2)
CIDEC cell death-inducing DFFA-like effector c
CINP cyclin-dependent kinase 2 interacting protein
CISH cytokine inducible SH2-containing protein
CTAGE9 CTAGE family, member 9
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAL4 dynein, axonemal, light chain 4
DOCK1 dedicator of cytokinesis 1
EDAR ectodysplasin A receptor
ELMO3 engulfment and cell motility 3
ERCC4 excision repair cross-complementation group 4
FAN1 FANCD2/FANCI-associated nuclease 1
FBXL2 F-box and leucine-rich repeat protein 2
FBXO31 F-box protein 31
FBXO46 F-box protein 46
FER fer (fps/fes related) tyrosine kinase
FURIN furin (paired basic amino acid cleaving enzyme)
GADD45G growth arrest and DNA-damage-inducible, gamma
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLI3 GLI family zinc finger 3
GPR27 G protein-coupled receptor 27
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIRA histone cell cycle regulator
HIST1H4F histone cluster 1, H4f
HLA-J major histocompatibility complex, class I, J (pseudogene)
IL15RA interleukin 15 receptor, alpha
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
LGALS4 lectin, galactoside-binding, soluble, 4
LINS lines homolog (Drosophila)
LY6D lymphocyte antigen 6 complex, locus D
MANBA mannosidase, beta A, lysosomal
MCOLN1 mucolipin 1
MTRF1 mitochondrial translational release factor 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NEK11 NIMA-related kinase 11
NOTCH1 notch 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX26 peroxisomal biogenesis factor 26
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RCOR3 REST corepressor 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIPK4 receptor-interacting serine-threonine kinase 4
RNF2 ring finger protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
SH3BGR SH3 domain binding glutamate-rich protein
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SND1-IT1 SND1 intronic transcript 1
SOX12 SRY (sex determining region Y)-box 12
SOX3 SRY (sex determining region Y)-box 3
SREK1IP1 SREK1-interacting protein 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD5 StAR-related lipid transfer (START) domain containing 5
TCTN1 tectonic family member 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM51 transmembrane protein 51
TMPRSS4 transmembrane protease, serine 4
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRAF2 TNF receptor-associated factor 2
UNC119 unc-119 homolog (C. elegans)
USP36 ubiquitin specific peptidase 36
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR62 WD repeat domain 62
WDR76 WD repeat domain 76
YIPF1 Yip1 domain family, member 1
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF250 zinc finger protein 250
ZNF276 zinc finger protein 276
ZNF324 zinc finger protein 324
ZNF480 zinc finger protein 480
ZXDC ZXD family zinc finger C