trifluoperazine-910 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trifluoperazine-910 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOE apolipoprotein E
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BST1 bone marrow stromal cell antigen 1
CCNG2 cyclin G2
CD58 CD58 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CGA glycoprotein hormones, alpha polypeptide
COL1A1 collagen, type I, alpha 1
CPN2 carboxypeptidase N, polypeptide 2
CRELD1 cysteine-rich with EGF-like domains 1
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYHR1 cysteine/histidine-rich 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
FADS3 fatty acid desaturase 3
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL1 four and a half LIM domains 1
FNDC3A fibronectin type III domain containing 3A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXJ3 forkhead box J3
GAMT guanidinoacetate N-methyltransferase
GEM GTP binding protein overexpressed in skeletal muscle
GRB7 growth factor receptor-bound protein 7
GSK3A glycogen synthase kinase 3 alpha
HDAC5 histone deacetylase 5
HIST1H3B histone cluster 1, H3b
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IL1R1 interleukin 1 receptor, type I
INADL InaD-like (Drosophila)
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
KREMEN2 kringle containing transmembrane protein 2
LHX6 LIM homeobox 6
LPIN1 lipin 1
LZTFL1 leucine zipper transcription factor-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MBTD1 mbt domain containing 1
MIR622 microRNA 622
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MVK mevalonate kinase
MXD4 MAX dimerization protein 4
NDRG1 N-myc downstream regulated 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKX3-2 NK3 homeobox 2
NRP2 neuropilin 2
NT5M 5',3'-nucleotidase, mitochondrial
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G3 phospholipase A2, group III
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
RIMS2 regulating synaptic membrane exocytosis 2
RNASE4 ribonuclease, RNase A family, 4
RND1 Rho family GTPase 1
RRBP1 ribosome binding protein 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOX9 SRY (sex determining region Y)-box 9
SPATA1 spermatogenesis associated 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRCAP Snf2-related CREBBP activator protein
ST20 suppressor of tumorigenicity 20
SUGP1 SURP and G patch domain containing 1
THBS3 thrombospondin 3
TLE4 transducin-like enhancer of split 4
TMEM259 transmembrane protein 259
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TREX1 three prime repair exonuclease 1
TRIM2 tripartite motif containing 2
TRIM23 tripartite motif containing 23
UBE2D2 ubiquitin-conjugating enzyme E2D 2
ZNF350 zinc finger protein 350
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
APIP APAF1 interacting protein
ASB6 ankyrin repeat and SOCS box containing 6
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C14ORF93 chromosome 14 open reading frame 93
C16ORF59 chromosome 16 open reading frame 59
C22ORF29 chromosome 22 open reading frame 29
CAMKMT calmodulin-lysine N-methyltransferase
CCDC25 coiled-coil domain containing 25
CCNE2 cyclin E2
CCNO cyclin O
CDK8 cyclin-dependent kinase 8
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CEP72 centrosomal protein 72kDa
CEP97 centrosomal protein 97kDa
DBR1 debranching RNA lariats 1
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
EEA1 early endosome antigen 1
ELOVL4 ELOVL fatty acid elongase 4
ESRP2 epithelial splicing regulatory protein 2
FAM155B family with sequence similarity 155, member B
FOXC1 forkhead box C1
FURIN furin (paired basic amino acid cleaving enzyme)
GPALPP1 GPALPP motifs containing 1
GSTM2 glutathione S-transferase mu 2 (muscle)
HIRA histone cell cycle regulator
HMHA1 histocompatibility (minor) HA-1
HOXC10 homeobox C10
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFT22 intraflagellar transport 22
IPP intracisternal A particle-promoted polypeptide
IRAK4 interleukin-1 receptor-associated kinase 4
KCNK15 potassium channel, two pore domain subfamily K, member 15
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIN7B lin-7 homolog B (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LOC100287590 uncharacterized LOC100287590
LRP3 low density lipoprotein receptor-related protein 3
LYPD3 LY6/PLAUR domain containing 3
MAGOHB mago-nashi homolog B (Drosophila)
MAP9 microtubule-associated protein 9
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEIS1 Meis homeobox 1
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MT1HL1 metallothionein 1H-like 1
MYNN myoneurin
NAG18 NAG18 mRNA
NLRX1 NLR family member X1
NUPL2 nucleoporin like 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARD6A par-6 family cell polarity regulator alpha
PCBP4 poly(rC) binding protein 4
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMCH pro-melanin-concentrating hormone
PTK6 protein tyrosine kinase 6
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBL1 retinoblastoma-like 1
RCL1 RNA terminal phosphate cyclase-like 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNMTL1 RNA methyltransferase like 1
SAMD9 sterile alpha motif domain containing 9
SCAP SREBF chaperone
SCN1B sodium channel, voltage gated, type I beta subunit
SLC35F6 solute carrier family 35, member F6
SNX10 sorting nexin 10
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TM7SF3 transmembrane 7 superfamily member 3
TMEM168 transmembrane protein 168
TMEM183A transmembrane protein 183A
TMEM38B transmembrane protein 38B
TMPRSS4 transmembrane protease, serine 4
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TUBA4A tubulin, alpha 4a
UBE2W ubiquitin-conjugating enzyme E2W (putative)
USB1 U6 snRNA biogenesis 1
WDR60 WD repeat domain 60
WDR76 WD repeat domain 76
ZC3H3 zinc finger CCCH-type containing 3
ZFP30 ZFP30 zinc finger protein
ZNF212 zinc finger protein 212
ZNF254 zinc finger protein 254
ZNF35 zinc finger protein 35
ZNF668 zinc finger protein 668
ZNF85 zinc finger protein 85
ZW10 zw10 kinetochore protein