trifluoperazine-6341 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the trifluoperazine-6341 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADCY6 adenylate cyclase 6
ALB albumin
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATF6B activating transcription factor 6 beta
BTN3A3 butyrophilin, subfamily 3, member A3
C1ORF54 chromosome 1 open reading frame 54
C8ORF44 chromosome 8 open reading frame 44
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDRT1 CMT1A duplicated region transcript 1
CISH cytokine inducible SH2-containing protein
CNN1 calponin 1, basic, smooth muscle
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYTH1 cytohesin 1
DCTN1 dynactin 1
DDIT3 DNA-damage-inducible transcript 3
ELSPBP1 epididymal sperm binding protein 1
FAM189A1 family with sequence similarity 189, member A1
FGF1 fibroblast growth factor 1 (acidic)
FGF16 fibroblast growth factor 16
FOXO1 forkhead box O1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HPS1 Hermansky-Pudlak syndrome 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INO80B INO80 complex subunit B
INSIG1 insulin induced gene 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNK1 potassium channel, two pore domain subfamily K, member 1
KHK ketohexokinase (fructokinase)
LAMC2 laminin, gamma 2
LAX1 lymphocyte transmembrane adaptor 1
LDB1 LIM domain binding 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
MAP7 microtubule-associated protein 7
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRPL44 mitochondrial ribosomal protein L44
MT1M metallothionein 1M
MVK mevalonate kinase
NCALD neurocalcin delta
NOD1 nucleotide-binding oligomerization domain containing 1
NOL10 nucleolar protein 10
NR0B2 nuclear receptor subfamily 0, group B, member 2
NSD1 nuclear receptor binding SET domain protein 1
NUMA1 nuclear mitotic apparatus protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PHF7 PHD finger protein 7
PLCD1 phospholipase C, delta 1
PLD2 phospholipase D2
PLK3 polo-like kinase 3
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PTBP3 polypyrimidine tract binding protein 3
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SCN10A sodium channel, voltage gated, type X alpha subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SIRT4 sirtuin 4
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOS2 son of sevenless homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SRRT serrate, RNA effector molecule
STBD1 starch binding domain 1
STC1 stanniocalcin 1
STK16 serine/threonine kinase 16
STX16 syntaxin 16
TBC1D30 TBC1 domain family, member 30
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
THBD thrombomodulin
TMEM50B transmembrane protein 50B
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIB3 tribbles pseudokinase 3
TUBGCP2 tubulin, gamma complex associated protein 2
ULBP2 UL16 binding protein 2
UNC13A unc-13 homolog A (C. elegans)
USP20 ubiquitin specific peptidase 20
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ADGRF1 adhesion G protein-coupled receptor F1
ALPK1 alpha-kinase 1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF63 chromosome 11 open reading frame 63
C11ORF95 chromosome 11 open reading frame 95
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFAP44 cilia and flagella associated protein 44
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTPS1 CTP synthase 1
CUL9 cullin 9
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DGKZ diacylglycerol kinase, zeta
DPH2 DPH2 homolog (S. cerevisiae)
ELP3 elongator acetyltransferase complex subunit 3
ETV4 ets variant 4
EXOC5 exocyst complex component 5
F8 coagulation factor VIII, procoagulant component
FAM160B2 family with sequence similarity 160, member B2
FAM168B family with sequence similarity 168, member B
FAM192A family with sequence similarity 192, member A
FHOD3 formin homology 2 domain containing 3
FKBPL FK506 binding protein like
FUZ fuzzy planar cell polarity protein
FZD3 frizzled class receptor 3
GALE UDP-galactose-4-epimerase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR176 G protein-coupled receptor 176
GPR87 G protein-coupled receptor 87
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HIRA histone cell cycle regulator
HOXA4 homeobox A4
HOXC8 homeobox C8
IL7R interleukin 7 receptor
KDM5C lysine (K)-specific demethylase 5C
KIAA1462 KIAA1462
KIAA1549L KIAA1549-like
LIMS2 LIM and senescent cell antigen-like domains 2
LOC730101 uncharacterized LOC730101
MAGEH1 melanoma antigen family H1
MCM3 minichromosome maintenance complex component 3
MED15 mediator complex subunit 15
MICALL2 MICAL-like 2
MPDU1 mannose-P-dolichol utilization defect 1
MRPL28 mitochondrial ribosomal protein L28
MTG1 mitochondrial ribosome-associated GTPase 1
MYL9 myosin, light chain 9, regulatory
NABP2 nucleic acid binding protein 2
NHLRC2 NHL repeat containing 2
NPY1R neuropeptide Y receptor Y1
NRSN2 neurensin 2
PACS1 phosphofurin acidic cluster sorting protein 1
PLAC1 placenta-specific 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POMT2 protein-O-mannosyltransferase 2
PRR3 proline rich 3
QTRT1 queuine tRNA-ribosyltransferase 1
RIBC2 RIB43A domain with coiled-coils 2
RIN1 Ras and Rab interactor 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC46A3 solute carrier family 46, member 3
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SND1-IT1 SND1 intronic transcript 1
SNX5 sorting nexin 5
SOBP sine oculis binding protein homolog (Drosophila)
ST5 suppression of tumorigenicity 5
STAG3 stromal antigen 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SUGP1 SURP and G patch domain containing 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAOK1 TAO kinase 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TEX10 testis expressed 10
THEM6 thioesterase superfamily member 6
TM7SF2 transmembrane 7 superfamily member 2
TMEM57 transmembrane protein 57
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
UNG uracil-DNA glycosylase
VEGFB vascular endothelial growth factor B
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WASF3 WAS protein family, member 3
WDR46 WD repeat domain 46
WDR76 WD repeat domain 76
ZBTB48 zinc finger and BTB domain containing 48
ZNF180 zinc finger protein 180
ZNF254 zinc finger protein 254
ZNF623 zinc finger protein 623
ZXDC ZXD family zinc finger C