trifluoperazine-421 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the trifluoperazine-421 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
AATK apoptosis-associated tyrosine kinase
ABHD2 abhydrolase domain containing 2
ACOT11 acyl-CoA thioesterase 11
ADRA1A adrenoceptor alpha 1A
AHCYL2 adenosylhomocysteinase-like 2
APOC1 apolipoprotein C-I
AQP3 aquaporin 3 (Gill blood group)
ARID4A AT rich interactive domain 4A (RBP1-like)
ASCL3 achaete-scute family bHLH transcription factor 3
ATF6 activating transcription factor 6
ATRN attractin
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
CAPN9 calpain 9
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CDK8 cyclin-dependent kinase 8
CENPI centromere protein I
COG5 component of oligomeric golgi complex 5
CRAT carnitine O-acetyltransferase
CRMP1 collapsin response mediator protein 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DSCAM Down syndrome cell adhesion molecule
DXO decapping exoribonuclease
E2F1 E2F transcription factor 1
E2F5 E2F transcription factor 5, p130-binding
EGR3 early growth response 3
ETV1 ets variant 1
FAM153A family with sequence similarity 153, member A
FKBP8 FK506 binding protein 8, 38kDa
FOLR1 folate receptor 1 (adult)
GON4L gon-4-like (C. elegans)
GRPR gastrin-releasing peptide receptor
HBP1 HMG-box transcription factor 1
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDI1 isopentenyl-diphosphate delta isomerase 1
IL6ST interleukin 6 signal transducer
INO80B INO80 complex subunit B
INSIG1 insulin induced gene 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JAKMIP2 janus kinase and microtubule interacting protein 2
KDM6B lysine (K)-specific demethylase 6B
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LPP LIM domain containing preferred translocation partner in lipoma
MAOA monoamine oxidase A
MAP2K4 mitogen-activated protein kinase kinase 4
MBD1 methyl-CpG binding domain protein 1
MLX MLX, MAX dimerization protein
MOB3B MOB kinase activator 3B
MOSPD2 motile sperm domain containing 2
MPPE1 metallophosphoesterase 1
MPPED1 metallophosphoesterase domain containing 1
MSMO1 methylsterol monooxygenase 1
MVK mevalonate kinase
MYO6 myosin VI
NOTCH3 notch 3
NPEPL1 aminopeptidase-like 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PAQR6 progestin and adipoQ receptor family member VI
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKN2 protein kinase N2
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PSG9 pregnancy specific beta-1-glycoprotein 9
RBL2 retinoblastoma-like 2
SAA4 serum amyloid A4, constitutive
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3PXD2A SH3 and PX domains 2A
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STAG2 stromal antigen 2
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYNRG synergin, gamma
SYT2 synaptotagmin II
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAOK2 TAO kinase 2
TGM5 transglutaminase 5
TMEM194A transmembrane protein 194A
TMPRSS5 transmembrane protease, serine 5
TRAFD1 TRAF-type zinc finger domain containing 1
UBE4B ubiquitination factor E4B
UBL3 ubiquitin-like 3
UBQLN4 ubiquilin 4
VAC14 Vac14 homolog (S. cerevisiae)
VRK3 vaccinia related kinase 3
WASF1 WAS protein family, member 1
WDR48 WD repeat domain 48
YIPF2 Yip1 domain family, member 2
ZNF638 zinc finger protein 638

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACSL5 acyl-CoA synthetase long-chain family member 5
AEN apoptosis enhancing nuclease
ANO10 anoctamin 10
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
AQP8 aquaporin 8
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASCC1 activating signal cointegrator 1 complex subunit 1
ASIC4 acid sensing (proton gated) ion channel family member 4
BAHD1 bromo adjacent homology domain containing 1
C16ORF59 chromosome 16 open reading frame 59
C1ORF159 chromosome 1 open reading frame 159
C2CD2 C2 calcium-dependent domain containing 2
CCNJL cyclin J-like
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CES3 carboxylesterase 3
CHAF1B chromatin assembly factor 1, subunit B (p60)
CLEC1A C-type lectin domain family 1, member A
CNGB3 cyclic nucleotide gated channel beta 3
CPB1 carboxypeptidase B1 (tissue)
CSN2 casein beta
CTNNBIP1 catenin, beta interacting protein 1
CUZD1 CUB and zona pellucida-like domains 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DUSP22 dual specificity phosphatase 22
E2F8 E2F transcription factor 8
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM76A family with sequence similarity 76, member A
FANCF Fanconi anemia, complementation group F
FGF6 fibroblast growth factor 6
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FSD1 fibronectin type III and SPRY domain containing 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GDF3 growth differentiation factor 3
GDF9 growth differentiation factor 9
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUCA2A guanylate cyclase activator 2A (guanylin)
HIST1H2AI histone cluster 1, H2ai
HOXC4 homeobox C4
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
IFNA14 interferon, alpha 14
IL15RA interleukin 15 receptor, alpha
IL17RA interleukin 17 receptor A
JAM2 junctional adhesion molecule 2
JOSD1 Josephin domain containing 1
KCNK15 potassium channel, two pore domain subfamily K, member 15
KRT32 keratin 32, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIAS lipoic acid synthetase
LIN7B lin-7 homolog B (C. elegans)
LINC01558 long intergenic non-protein coding RNA 1558
LRRC37A3 leucine rich repeat containing 37, member A3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6G6D lymphocyte antigen 6 complex, locus G6D
MAST3 microtubule associated serine/threonine kinase 3
MED23 mediator complex subunit 23
MED9 mediator complex subunit 9
MEGF6 multiple EGF-like-domains 6
METTL2B methyltransferase like 2B
MRPS2 mitochondrial ribosomal protein S2
MYO1F myosin IF
NARFL nuclear prelamin A recognition factor-like
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NLRX1 NLR family member X1
NRGN neurogranin (protein kinase C substrate, RC3)
PARD6A par-6 family cell polarity regulator alpha
PAX1 paired box 1
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PMP22 peripheral myelin protein 22
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RBP1 retinol binding protein 1, cellular
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCNM1 sodium channel modifier 1
SELL selectin L
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOD3 superoxide dismutase 3, extracellular
STAT4 signal transducer and activator of transcription 4
TMEM110 transmembrane protein 110
TNS2 tensin 2
TOE1 target of EGR1, member 1 (nuclear)
TRAF5 TNF receptor-associated factor 5
TRAPPC12 trafficking protein particle complex 12
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
VAX2 ventral anterior homeobox 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
ZNF354A zinc finger protein 354A
ZNHIT2 zinc finger, HIT-type containing 2