trifluoperazine-2389 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trifluoperazine-2389 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
AURKA aurora kinase A
BAGE B melanoma antigen
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C1ORF68 chromosome 1 open reading frame 68
CAPN2 calpain 2, (m/II) large subunit
CCNG2 cyclin G2
CD58 CD58 molecule
CDC25C cell division cycle 25C
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLEC4E C-type lectin domain family 4, member E
CLUAP1 clusterin associated protein 1
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COQ6 coenzyme Q6 monooxygenase
CRELD1 cysteine-rich with EGF-like domains 1
CSF3 colony stimulating factor 3 (granulocyte)
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLX2 distal-less homeobox 2
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EDNRA endothelin receptor type A
EFNA3 ephrin-A3
EMC3 ER membrane protein complex subunit 3
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FAM46C family with sequence similarity 46, member C
FGF16 fibroblast growth factor 16
FOXG1 forkhead box G1
FXYD2 FXYD domain containing ion transport regulator 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GMPR guanosine monophosphate reductase
GPNMB glycoprotein (transmembrane) nmb
HDAC7 histone deacetylase 7
HEXIM1 hexamethylene bis-acetamide inducible 1
HFE hemochromatosis
HOXB6 homeobox B6
HPX hemopexin
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL27RA interleukin 27 receptor, alpha
IRS4 insulin receptor substrate 4
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCTD2 potassium channel tetramerization domain containing 2
KIAA1107 KIAA1107
KLF2 Kruppel-like factor 2
LAD1 ladinin 1
LPIN1 lipin 1
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAN1A2 mannosidase, alpha, class 1A, member 2
MBOAT2 membrane bound O-acyltransferase domain containing 2
MOB3B MOB kinase activator 3B
MPZ myelin protein zero
MTMR8 myotubularin related protein 8
NF1 neurofibromin 1
NPEPL1 aminopeptidase-like 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR7A10 olfactory receptor, family 7, subfamily A, member 10
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PARVB parvin, beta
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHB1 protocadherin beta 1
PCDHGB5 protocadherin gamma subfamily B, 5
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRX periaxin
PTCRA pre T-cell antigen receptor alpha
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RELN reelin
RHBDD3 rhomboid domain containing 3
ROR1 receptor tyrosine kinase-like orphan receptor 1
RUNDC3A RUN domain containing 3A
RUNX1 runt-related transcription factor 1
SELPLG selectin P ligand
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SFRP5 secreted frizzled-related protein 5
SH3PXD2A SH3 and PX domains 2A
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SPAG4 sperm associated antigen 4
SPRR1B small proline-rich protein 1B
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSBP2 single-stranded DNA binding protein 2
TBKBP1 TBK1 binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D4 TSC22 domain family, member 4
TTLL3 tubulin tyrosine ligase-like family member 3
TULP2 tubby like protein 2
UGCG UDP-glucose ceramide glucosyltransferase
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF280B zinc finger protein 280B
ZNF34 zinc finger protein 34
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACAD10 acyl-CoA dehydrogenase family, member 10
ADTRP androgen-dependent TFPI-regulating protein
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOBR apolipoprotein B receptor
AXIN1 axin 1
BACE1 beta-site APP-cleaving enzyme 1
BTBD2 BTB (POZ) domain containing 2
C16ORF59 chromosome 16 open reading frame 59
C22ORF46 chromosome 22 open reading frame 46
C9ORF40 chromosome 9 open reading frame 40
CCL2 chemokine (C-C motif) ligand 2
CCNT1 cyclin T1
CD82 CD82 molecule
CDA cytidine deaminase
CDR2L cerebellar degeneration-related protein 2-like
CENPT centromere protein T
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPTP ceramide-1-phosphate transfer protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSL cathepsin L
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
E4F1 E4F transcription factor 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHBP1L1 EH domain binding protein 1-like 1
ENDOG endonuclease G
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FAM118A family with sequence similarity 118, member A
FAM160B2 family with sequence similarity 160, member B2
FAM184A family with sequence similarity 184, member A
FCHO1 FCH domain only 1
FLCN folliculin
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GRPR gastrin-releasing peptide receptor
GRWD1 glutamate-rich WD repeat containing 1
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HYAL2 hyaluronoglucosaminidase 2
IGFLR1 IGF-like family receptor 1
IL4R interleukin 4 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ISOC2 isochorismatase domain containing 2
JADE3 jade family PHD finger 3
METTL16 methyltransferase like 16
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MON1B MON1 secretory trafficking family member B
MPDU1 mannose-P-dolichol utilization defect 1
MPI mannose phosphate isomerase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTA2 metastasis associated 1 family, member 2
MXD3 MAX dimerization protein 3
MYO5C myosin VC
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NHEJ1 nonhomologous end-joining factor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NTSR1 neurotensin receptor 1 (high affinity)
PADI1 peptidyl arginine deiminase, type I
PARG poly (ADP-ribose) glycohydrolase
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PDZD7 PDZ domain containing 7
PFAS phosphoribosylformylglycinamidine synthase
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PMCH pro-melanin-concentrating hormone
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PYCRL pyrroline-5-carboxylate reductase-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARS arginyl-tRNA synthetase
RFTN1 raftlin, lipid raft linker 1
RFWD3 ring finger and WD repeat domain 3
RFXAP regulatory factor X-associated protein
RGS19 regulator of G-protein signaling 19
SCAI suppressor of cancer cell invasion
SHARPIN SHANK-associated RH domain interactor
SIRT6 sirtuin 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
STARD3 StAR-related lipid transfer (START) domain containing 3
TMEM156 transmembrane protein 156
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
URGCP upregulator of cell proliferation
USP27X ubiquitin specific peptidase 27, X-linked
WDR60 WD repeat domain 60
ZBTB39 zinc finger and BTB domain containing 39
ZC4H2 zinc finger, C4H2 domain containing
ZNF222 zinc finger protein 222
ZNF37BP zinc finger protein 37B, pseudogene
ZNF551 zinc finger protein 551
ZNF667 zinc finger protein 667