trichostatin A-981 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-981 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
BAIAP2 BAI1-associated protein 2
CCDC28A coiled-coil domain containing 28A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP2 cysteine and glycine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL4 dihydropyrimidinase-like 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB3 ephrin-B3
ELOVL4 ELOVL fatty acid elongase 4
EPOR erythropoietin receptor
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FYN FYN proto-oncogene, Src family tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IRF7 interferon regulatory factor 7
KIAA0513 KIAA0513
KIF5C kinesin family member 5C
LIMA1 LIM domain and actin binding 1
LMCD1 LIM and cysteine-rich domains 1
LYST lysosomal trafficking regulator
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MCOLN1 mucolipin 1
MITF microphthalmia-associated transcription factor
MLF1 myeloid leukemia factor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
OASL 2'-5'-oligoadenylate synthetase-like
PADI3 peptidyl arginine deiminase, type III
PAIP2B poly(A) binding protein interacting protein 2B
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLLP plasmolipin
PRPH peripherin
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RIPK4 receptor-interacting serine-threonine kinase 4
RND1 Rho family GTPase 1
RNFT2 ring finger protein, transmembrane 2
RPL3L ribosomal protein L3-like
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
RUNDC3B RUN domain containing 3B
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGR SH3 domain binding glutamate-rich protein
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SNAI2 snail family zinc finger 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STON1 stonin 1
SYT11 synaptotagmin XI
TIMP3 TIMP metallopeptidase inhibitor 3
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
ULBP2 UL16 binding protein 2
VIPR1 vasoactive intestinal peptide receptor 1
WDR19 WD repeat domain 19
WDR47 WD repeat domain 47
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF10 zinc finger protein 10
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
BANP BTG3 associated nuclear protein
BATF basic leucine zipper transcription factor, ATF-like
BCAR3 breast cancer anti-estrogen resistance 3
BPTF bromodomain PHD finger transcription factor
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C7ORF49 chromosome 7 open reading frame 49
CASD1 CAS1 domain containing 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC94 coiled-coil domain containing 94
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUL1 cullin 1
CXCL12 chemokine (C-X-C motif) ligand 12
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFCAB2 EF-hand calcium binding domain 2
EFNA1 ephrin-A1
EGR3 early growth response 3
FAM193A family with sequence similarity 193, member A
FAM57A family with sequence similarity 57, member A
FOXA1 forkhead box A1
FOXC1 forkhead box C1
FOXD1 forkhead box D1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GTF2IRD1 GTF2I repeat domain containing 1
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0125 KIAA0125
LMNB1 lamin B1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LUC7L2 LUC7-like 2 (S. cerevisiae)
MANSC1 MANSC domain containing 1
MCM9 minichromosome maintenance complex component 9
MEPCE methylphosphate capping enzyme
METTL4 methyltransferase like 4
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MSL1 male-specific lethal 1 homolog (Drosophila)
MSL2 male-specific lethal 2 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSD1 nuclear receptor binding SET domain protein 1
NUAK1 NUAK family, SNF1-like kinase, 1
PAPD7 PAP associated domain containing 7
PEX12 peroxisomal biogenesis factor 12
POGK pogo transposable element with KRAB domain
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRR15L proline rich 15-like
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM23 RNA binding motif protein 23
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SETD1B SET domain containing 1B
SFMBT1 Scm-like with four mbt domains 1
SIAH1 siah E3 ubiquitin protein ligase 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF4 serine/arginine-rich splicing factor 4
STC2 stanniocalcin 2
STRN4 striatin, calmodulin binding protein 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TMEM30B transmembrane protein 30B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOE1 target of EGR1, member 1 (nuclear)
TRAF5 TNF receptor-associated factor 5
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM8 tripartite motif containing 8
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
UBXN8 UBX domain protein 8
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZFHX3 zinc finger homeobox 3
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZNF692 zinc finger protein 692
ZNF787 zinc finger protein 787