trichostatin A-7105 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-7105 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADRB2 adrenoceptor beta 2, surface
AGFG2 ArfGAP with FG repeats 2
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BMP6 bone morphogenetic protein 6
C2CD2L C2CD2-like
C8ORF60 chromosome 8 open reading frame 60
CACTIN cactin, spliceosome C complex subunit
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHKA choline kinase alpha
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CPA4 carboxypeptidase A4
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSNK1E casein kinase 1, epsilon
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA3 ephrin-A3
EFNB2 ephrin-B2
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
FABP4 fatty acid binding protein 4, adipocyte
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXO1 forkhead box O1
FSCN1 fascin actin-bundling protein 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCDH glutaryl-CoA dehydrogenase
GMPR guanosine monophosphate reductase
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1FX H1 histone family, member X
HBEGF heparin-binding EGF-like growth factor
HSPA2 heat shock 70kDa protein 2
IL11 interleukin 11
IL1RAP interleukin 1 receptor accessory protein
INSIG1 insulin induced gene 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAP2K3 mitogen-activated protein kinase kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
NEU1 sialidase 1 (lysosomal sialidase)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
PCDH9 protocadherin 9
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK2 polo-like kinase 2
PLXNA3 plexin A3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPH peripherin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB3B RAB3B, member RAS oncogene family
RAI2 retinoic acid induced 2
RBBP6 retinoblastoma binding protein 6
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORBS1 sorbin and SH3 domain containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STOM stomatin
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TAOK3 TAO kinase 3
TBPL1 TBP-like 1
TPMT thiopurine S-methyltransferase
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM29 tripartite motif containing 29
TRIM62 tripartite motif containing 62
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APH1A APH1A gamma secretase subunit
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATAD2B ATPase family, AAA domain containing 2B
ATF1 activating transcription factor 1
BAG2 BCL2-associated athanogene 2
BCAR3 breast cancer anti-estrogen resistance 3
BHLHE41 basic helix-loop-helix family, member e41
BRD1 bromodomain containing 1
C11ORF30 chromosome 11 open reading frame 30
C1ORF216 chromosome 1 open reading frame 216
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CLCF1 cardiotrophin-like cytokine factor 1
COIL coilin
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DUSP4 dual specificity phosphatase 4
E2F8 E2F transcription factor 8
EYA4 EYA transcriptional coactivator and phosphatase 4
FADD Fas (TNFRSF6)-associated via death domain
FAIM Fas apoptotic inhibitory molecule
FAM50B family with sequence similarity 50, member B
FAM60A family with sequence similarity 60, member A
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HMGB3P1 high mobility group box 3 pseudogene 1
IL33 interleukin 33
INHBB inhibin, beta B
ITPKB inositol-trisphosphate 3-kinase B
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIFC1 kinesin family member C1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MEPCE methylphosphate capping enzyme
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NSD1 nuclear receptor binding SET domain protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORC2 origin recognition complex, subunit 2
PALMD palmdelphin
PARP12 poly (ADP-ribose) polymerase family, member 12
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
QRICH1 glutamine-rich 1
RBM23 RNA binding motif protein 23
RBM4B RNA binding motif protein 4B
RIN2 Ras and Rab interactor 2
RNF220 ring finger protein 220
SCAF8 SR-related CTD-associated factor 8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SFMBT1 Scm-like with four mbt domains 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIM2 single-minded family bHLH transcription factor 2
SLC35F2 solute carrier family 35, member F2
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMAGP small cell adhesion glycoprotein
SRSF4 serine/arginine-rich splicing factor 4
SRSF8 serine/arginine-rich splicing factor 8
STAG1 stromal antigen 1
TCEAL1 transcription elongation factor A (SII)-like 1
TRIB3 tribbles pseudokinase 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
URGCP upregulator of cell proliferation
VEGFC vascular endothelial growth factor C
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZC3H7A zinc finger CCCH-type containing 7A
ZNF248 zinc finger protein 248
ZNF282 zinc finger protein 282
ZNF532 zinc finger protein 532
ZNF692 zinc finger protein 692