trichostatin A-6916 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the trichostatin A-6916 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACYP1 acylphosphatase 1, erythrocyte (common) type
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CEP76 centrosomal protein 76kDa
CLGN calmegin
CLMN calmin (calponin-like, transmembrane)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CXADR coxsackie virus and adenovirus receptor
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL4 dihydropyrimidinase-like 4
EAF2 ELL associated factor 2
ELOVL4 ELOVL fatty acid elongase 4
EPOR erythropoietin receptor
EVI5 ecotropic viral integration site 5
FKBP1B FK506 binding protein 1B, 12.6 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GCA grancalcin, EF-hand calcium binding protein
GEM GTP binding protein overexpressed in skeletal muscle
GLCE glucuronic acid epimerase
GLRX glutaredoxin (thioltransferase)
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA2 heat shock 70kDa protein 2
KCTD13 potassium channel tetramerization domain containing 13
KIAA0895 KIAA0895
KIDINS220 kinase D-interacting substrate, 220kDa
KIF16B kinesin family member 16B
KIF3A kinesin family member 3A
KIF5C kinesin family member 5C
LIMA1 LIM domain and actin binding 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MICB MHC class I polypeptide-related sequence B
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MTM1 myotubularin 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK1 NIMA-related kinase 1
NPC1 Niemann-Pick disease, type C1
NUP62CL nucleoporin 62kDa C-terminal like
NXN nucleoredoxin
PAIP2B poly(A) binding protein interacting protein 2B
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIKFYVE phosphoinositide kinase, FYVE finger containing
PPARD peroxisome proliferator-activated receptor delta
PRPH peripherin
PTCH1 patched 1
RAB40B RAB40B, member RAS oncogene family
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RP2 retinitis pigmentosa 2 (X-linked recessive)
RTN2 reticulon 2
RUNDC3B RUN domain containing 3B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGR SH3 domain binding glutamate-rich protein
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SNN stannin
SNX1 sorting nexin 1
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK17A serine/threonine kinase 17a
STON1 stonin 1
STXBP1 syntaxin binding protein 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYT11 synaptotagmin XI
TOX4 TOX high mobility group box family member 4
TUFT1 tuftelin 1
WDR19 WD repeat domain 19
WDR47 WD repeat domain 47
WDR60 WD repeat domain 60
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
AP4M1 adaptor-related protein complex 4, mu 1 subunit
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARAF A-Raf proto-oncogene, serine/threonine kinase
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BATF basic leucine zipper transcription factor, ATF-like
BAX BCL2-associated X protein
BCAR3 breast cancer anti-estrogen resistance 3
C9ORF91 chromosome 9 open reading frame 91
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC94 coiled-coil domain containing 94
CCND1 cyclin D1
CCNL2 cyclin L2
CDC37 cell division cycle 37
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
COA7 cytochrome c oxidase assembly factor 7 (putative)
COG7 component of oligomeric golgi complex 7
CRIP2 cysteine-rich protein 2
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUL1 cullin 1
CYC1 cytochrome c-1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCPS decapping enzyme, scavenger
DDA1 DET1 and DDB1 associated 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
ELF4 E74-like factor 4 (ets domain transcription factor)
ESRP2 epithelial splicing regulatory protein 2
FAM57A family with sequence similarity 57, member A
FAR2 fatty acyl CoA reductase 2
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
GABPB1 GA binding protein transcription factor, beta subunit 1
GTF2IRD1 GTF2I repeat domain containing 1
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
LMNB1 lamin B1
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MPDU1 mannose-P-dolichol utilization defect 1
MPPED2 metallophosphoesterase domain containing 2
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PEF1 penta-EF-hand domain containing 1
PGD phosphogluconate dehydrogenase
PLK1 polo-like kinase 1
POGK pogo transposable element with KRAB domain
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PPAP2C phosphatidic acid phosphatase type 2C
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRCC papillary renal cell carcinoma (translocation-associated)
PRMT1 protein arginine methyltransferase 1
PRR15L proline rich 15-like
PSENEN presenilin enhancer gamma secretase subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM23 RNA binding motif protein 23
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFMBT1 Scm-like with four mbt domains 1
SH2D4A SH2 domain containing 4A
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SMG9 SMG9 nonsense mediated mRNA decay factor
SMYD5 SMYD family member 5
SNORA21 small nucleolar RNA, H/ACA box 21
STC2 stanniocalcin 2
SYTL2 synaptotagmin-like 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOE1 target of EGR1, member 1 (nuclear)
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSSC4 tumor suppressing subtransferable candidate 4
UBE2M ubiquitin-conjugating enzyme E2M
USP21 ubiquitin specific peptidase 21
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAV1 vav 1 guanine nucleotide exchange factor
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR74 WD repeat domain 74
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZIC1 Zic family member 1
ZNF692 zinc finger protein 692