trichostatin A-6709 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-6709 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP68 centrosomal protein 68kDa
CFAP69 cilia and flagella associated protein 69
CLMN calmin (calponin-like, transmembrane)
COL21A1 collagen, type XXI, alpha 1
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
DLX2 distal-less homeobox 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL4 ELOVL fatty acid elongase 4
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPPK1 epiplakin 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM46C family with sequence similarity 46, member C
FAM69A family with sequence similarity 69, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
HOXA1 homeobox A1
IRF6 interferon regulatory factor 6
JAKMIP2 janus kinase and microtubule interacting protein 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
LIFR leukemia inhibitory factor receptor alpha
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAK male germ cell-associated kinase
MAP2K3 mitogen-activated protein kinase kinase 3
MED25 mediator complex subunit 25
MFAP3L microfibrillar-associated protein 3-like
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MMP1 matrix metallopeptidase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR5A2 nuclear receptor subfamily 5, group A, member 2
PCDH17 protocadherin 17
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RBM12B-AS1 RBM12B antisense RNA 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RPL10 ribosomal protein L10
RPL14 ribosomal protein L14
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SKI SKI proto-oncogene
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORBS1 sorbin and SH3 domain containing 1
SOSTDC1 sclerostin domain containing 1
SSBP2 single-stranded DNA binding protein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STOM stomatin
STON1 stonin 1
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM9 tripartite motif containing 9
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UBE2I ubiquitin-conjugating enzyme E2I
USP2 ubiquitin specific peptidase 2
VWA5A von Willebrand factor A domain containing 5A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ADAT1 adenosine deaminase, tRNA-specific 1
ADGRG6 adhesion G protein-coupled receptor G6
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
BCAR3 breast cancer anti-estrogen resistance 3
BGLAP bone gamma-carboxyglutamate (gla) protein
CAMK1 calcium/calmodulin-dependent protein kinase I
CASD1 CAS1 domain containing 1
CHM choroideremia (Rab escort protein 1)
CUL1 cullin 1
CYTH2 cytohesin 2
DDA1 DET1 and DDB1 associated 1
DEAF1 DEAF1 transcription factor
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
EMP3 epithelial membrane protein 3
FAIM Fas apoptotic inhibitory molecule
FAM60A family with sequence similarity 60, member A
FOXA1 forkhead box A1
FZD8 frizzled class receptor 8
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GJC1 gap junction protein, gamma 1, 45kDa
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
ICT1 immature colon carcinoma transcript 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ISOC2 isochorismatase domain containing 2
ITPKB inositol-trisphosphate 3-kinase B
KEAP1 kelch-like ECH-associated protein 1
KIAA0753 KIAA0753
KIRREL kin of IRRE like (Drosophila)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LZTR1 leucine-zipper-like transcription regulator 1
MALL mal, T-cell differentiation protein-like
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
MFSD5 major facilitator superfamily domain containing 5
MPDU1 mannose-P-dolichol utilization defect 1
MPI mannose phosphate isomerase
MRPL28 mitochondrial ribosomal protein L28
MRPS34 mitochondrial ribosomal protein S34
NABP2 nucleic acid binding protein 2
NCAPH non-SMC condensin I complex, subunit H
NME6 NME/NM23 nucleoside diphosphate kinase 6
NMI N-myc (and STAT) interactor
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PEF1 penta-EF-hand domain containing 1
PLK1 polo-like kinase 1
PPAN peter pan homolog (Drosophila)
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PUF60 poly-U binding splicing factor 60KDa
RBM4B RNA binding motif protein 4B
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIN2 Ras and Rab interactor 2
RNH1 ribonuclease/angiogenin inhibitor 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A4 S100 calcium binding protein A4
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD6 SET domain containing 6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMAGP small cell adhesion glycoprotein
SMYD5 SMYD family member 5
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
STBD1 starch binding domain 1
STX5 syntaxin 5
TARBP2 TAR (HIV-1) RNA binding protein 2
TCTN1 tectonic family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOE1 target of EGR1, member 1 (nuclear)
TRAPPC2L trafficking protein particle complex 2-like
TRIM16 tripartite motif containing 16
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
U2AF1 U2 small nuclear RNA auxiliary factor 1
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
VWA9 von Willebrand factor A domain containing 9
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR74 WD repeat domain 74
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZFP69B ZFP69 zinc finger protein B
ZMAT5 zinc finger, matrin-type 5
ZNF16 zinc finger protein 16
ZNF532 zinc finger protein 532
ZNF692 zinc finger protein 692
ZNF804A zinc finger protein 804A