trichostatin A-6546 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-6546 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADGRB2 adhesion G protein-coupled receptor B2
AGTR1 angiotensin II receptor, type 1
AKAP13 A kinase (PRKA) anchor protein 13
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
CCNA1 cyclin A1
CCSER2 coiled-coil serine-rich protein 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DENND3 DENN/MADD domain containing 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNB2 ephrin-B2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPPK1 epiplakin 1
FABP4 fatty acid binding protein 4, adipocyte
FYN FYN proto-oncogene, Src family tyrosine kinase
GABARAPL1 GABA(A) receptor-associated protein like 1
GCDH glutaryl-CoA dehydrogenase
GLS glutaminase
GMPR guanosine monophosphate reductase
GTF2B general transcription factor IIB
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H1FX H1 histone family, member X
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
INSIG1 insulin induced gene 1
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF13B kinesin family member 13B
KIF5C kinesin family member 5C
LINC00341 long intergenic non-protein coding RNA 341
LPIN1 lipin 1
MAX MYC associated factor X
MLF1 myeloid leukemia factor 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP1 matrix metallopeptidase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN3 neurexin 3
OASL 2'-5'-oligoadenylate synthetase-like
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPL periplakin
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RNF24 ring finger protein 24
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RWDD2A RWD domain containing 2A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK4 serine/threonine kinase 4
STOM stomatin
STON1 stonin 1
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TJP3 tight junction protein 3
TRIM9 tripartite motif containing 9
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
ZFP36 ZFP36 ring finger protein
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARSJ arylsulfatase family, member J
BANP BTG3 associated nuclear protein
BCAR3 breast cancer anti-estrogen resistance 3
BRD1 bromodomain containing 1
C1ORF216 chromosome 1 open reading frame 216
C9ORF91 chromosome 9 open reading frame 91
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CLCF1 cardiotrophin-like cytokine factor 1
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUL1 cullin 1
DUSP4 dual specificity phosphatase 4
E2F8 E2F transcription factor 8
EGF epidermal growth factor
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FADD Fas (TNFRSF6)-associated via death domain
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GBX2 gastrulation brain homeobox 2
GIN1 gypsy retrotransposon integrase 1
GPR87 G protein-coupled receptor 87
GPRC5C G protein-coupled receptor, class C, group 5, member C
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
ITPKB inositol-trisphosphate 3-kinase B
KCTD15 potassium channel tetramerization domain containing 15
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
MLPH melanophilin
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MSL1 male-specific lethal 1 homolog (Drosophila)
MTRF1 mitochondrial translational release factor 1
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PXDC1 PX domain containing 1
RBM23 RNA binding motif protein 23
RIN2 Ras and Rab interactor 2
RPAP1 RNA polymerase II associated protein 1
S100A4 S100 calcium binding protein A4
SCAF8 SR-related CTD-associated factor 8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SETMAR SET domain and mariner transposase fusion gene
SH2D4A SH2 domain containing 4A
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35F2 solute carrier family 35, member F2
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLTM SAFB-like, transcription modulator
SMAGP small cell adhesion glycoprotein
SRSF4 serine/arginine-rich splicing factor 4
STBD1 starch binding domain 1
TCEAL1 transcription elongation factor A (SII)-like 1
TCERG1 transcription elongation regulator 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TGIF1 TGFB-induced factor homeobox 1
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
UNKL unkempt family zinc finger-like
URGCP upregulator of cell proliferation
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WDR6 WD repeat domain 6
XBP1 X-box binding protein 1
ZBED1 zinc finger, BED-type containing 1
ZBTB38 zinc finger and BTB domain containing 38
ZC3H4 zinc finger CCCH-type containing 4
ZNF134 zinc finger protein 134
ZNF16 zinc finger protein 16
ZNF165 zinc finger protein 165
ZNF239 zinc finger protein 239
ZNF787 zinc finger protein 787