trichostatin A-5981 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-5981 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGTR1 angiotensin II receptor, type 1
AIM1L absent in melanoma 1-like
AMBRA1 autophagy/beclin-1 regulator 1
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
CA5B carbonic anhydrase VB, mitochondrial
CACYBP calcyclin binding protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFAP69 cilia and flagella associated protein 69
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN1 claudin 1
CLTCL1 clathrin, heavy chain-like 1
COL11A2 collagen, type XI, alpha 2
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
DENND3 DENN/MADD domain containing 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EDNRA endothelin receptor type A
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA3 ephrin-A3
EGR2 early growth response 2
ELOVL4 ELOVL fatty acid elongase 4
FABP4 fatty acid binding protein 4, adipocyte
FAM102A family with sequence similarity 102, member A
FAM110B family with sequence similarity 110, member B
FAM134B family with sequence similarity 134, member B
FAM188A family with sequence similarity 188, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLCE glucuronic acid epimerase
GMPR guanosine monophosphate reductase
GUCY1B3 guanylate cyclase 1, soluble, beta 3
IL7 interleukin 7
ING2 inhibitor of growth family, member 2
INSIG1 insulin induced gene 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0895 KIAA0895
KIF5C kinesin family member 5C
KLF2 Kruppel-like factor 2
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAK male germ cell-associated kinase
MERTK MER proto-oncogene, tyrosine kinase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NPC1 Niemann-Pick disease, type C1
OASL 2'-5'-oligoadenylate synthetase-like
PDE4DIP phosphodiesterase 4D interacting protein
PLAG1 pleiomorphic adenoma gene 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPH peripherin
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAI2 retinoic acid induced 2
RANBP1 RAN binding protein 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RPL37A ribosomal protein L37a
RUNDC3B RUN domain containing 3B
SAP30 Sin3A-associated protein, 30kDa
SCD5 stearoyl-CoA desaturase 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STOM stomatin
STON1 stonin 1
SYT11 synaptotagmin XI
TBC1D2 TBC1 domain family, member 2
TBXA2R thromboxane A2 receptor
TFEC transcription factor EC
TJP3 tight junction protein 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
WDR19 WD repeat domain 19
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
ADNP activity-dependent neuroprotector homeobox
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARSJ arylsulfatase family, member J
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAG2 BCL2-associated athanogene 2
BCAR3 breast cancer anti-estrogen resistance 3
C11ORF63 chromosome 11 open reading frame 63
C1RL complement component 1, r subcomponent-like
C7ORF49 chromosome 7 open reading frame 49
C8ORF44 chromosome 8 open reading frame 44
CBR3 carbonyl reductase 3
CCDC94 coiled-coil domain containing 94
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COA7 cytochrome c oxidase assembly factor 7 (putative)
CUL1 cullin 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DEPDC1 DEP domain containing 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DUSP4 dual specificity phosphatase 4
ELF1 E74-like factor 1 (ets domain transcription factor)
FADD Fas (TNFRSF6)-associated via death domain
FAM169A family with sequence similarity 169, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GIN1 gypsy retrotransposon integrase 1
HAS2 hyaluronan synthase 2
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL7R interleukin 7 receptor
INHBB inhibin, beta B
ITPKB inositol-trisphosphate 3-kinase B
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
MEPCE methylphosphate capping enzyme
MTA2 metastasis associated 1 family, member 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHEJ1 nonhomologous end-joining factor 1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP12 poly (ADP-ribose) polymerase family, member 12
PCOLCE procollagen C-endopeptidase enhancer
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
POGK pogo transposable element with KRAB domain
POMT2 protein-O-mannosyltransferase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPCDC phosphopantothenoylcysteine decarboxylase
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTGFR prostaglandin F receptor (FP)
RBM4B RNA binding motif protein 4B
RIN2 Ras and Rab interactor 2
SCAF8 SR-related CTD-associated factor 8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMAGP small cell adhesion glycoprotein
SMG9 SMG9 nonsense mediated mRNA decay factor
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX12 SRY (sex determining region Y)-box 12
SRSF4 serine/arginine-rich splicing factor 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNPO synaptopodin
TEP1 telomerase-associated protein 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGIF1 TGFB-induced factor homeobox 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMC5 transmembrane channel-like 5
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRABD TraB domain containing
TRIB3 tribbles pseudokinase 3
URGCP upregulator of cell proliferation
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
VWA9 von Willebrand factor A domain containing 9
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZC3H4 zinc finger CCCH-type containing 4
ZNF532 zinc finger protein 532
ZNF692 zinc finger protein 692
ZNF711 zinc finger protein 711
ZNF76 zinc finger protein 76