trichostatin A-5950 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-5950 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BMP6 bone morphogenetic protein 6
C16ORF45 chromosome 16 open reading frame 45
CCDC68 coiled-coil domain containing 68
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLTCL1 clathrin, heavy chain-like 1
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DPYSL4 dihydropyrimidinase-like 4
DUSP1 dual specificity phosphatase 1
EFNA3 ephrin-A3
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPPK1 epiplakin 1
FABP4 fatty acid binding protein 4, adipocyte
FAM110B family with sequence similarity 110, member B
FYN FYN proto-oncogene, Src family tyrosine kinase
GK glycerol kinase
GMPR guanosine monophosphate reductase
GTF2B general transcription factor IIB
H1FX H1 histone family, member X
IL11 interleukin 11
IL1RAP interleukin 1 receptor accessory protein
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
LAMC2 laminin, gamma 2
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
MAP1A microtubule-associated protein 1A
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPT microtubule-associated protein tau
MITF microphthalmia-associated transcription factor
MMP1 matrix metallopeptidase 1
MSX2 msh homeobox 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME5 NME/NM23 family member 5
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OASL 2'-5'-oligoadenylate synthetase-like
PCDH9 protocadherin 9
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PGPEP1 pyroglutamyl-peptidase I
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPH peripherin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAI suppressor of cancer cell invasion
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL2 SH3-domain GRB2-like 2
SH3GL3 SH3-domain GRB2-like 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORBS1 sorbin and SH3 domain containing 1
SPATA7 spermatogenesis associated 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3 stromal antigen 3
STC1 stanniocalcin 1
STK17B serine/threonine kinase 17b
STOM stomatin
STON1 stonin 1
STX7 syntaxin 7
SYT11 synaptotagmin XI
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAFD1 TRAF-type zinc finger domain containing 1
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZCCHC14 zinc finger, CCHC domain containing 14
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADNP activity-dependent neuroprotector homeobox
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARSJ arylsulfatase family, member J
BCAR3 breast cancer anti-estrogen resistance 3
BCL7A B-cell CLL/lymphoma 7A
C19ORF40 chromosome 19 open reading frame 40
C7ORF49 chromosome 7 open reading frame 49
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CLCF1 cardiotrophin-like cytokine factor 1
CLDN14 claudin 14
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
DCLRE1A DNA cross-link repair 1A
DEPDC1 DEP domain containing 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
E2F8 E2F transcription factor 8
FAM169A family with sequence similarity 169, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF2 fibroblast growth factor 2 (basic)
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
FZD8 frizzled class receptor 8
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPR87 G protein-coupled receptor 87
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HOXB9 homeobox B9
INHBB inhibin, beta B
JADE1 jade family PHD finger 1
KAT6B K(lysine) acetyltransferase 6B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
LIF leukemia inhibitory factor
LMNB1 lamin B1
LRRC41 leucine rich repeat containing 41
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
METTL4 methyltransferase like 4
MTRF1 mitochondrial translational release factor 1
MX1 MX dynamin-like GTPase 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NSD1 nuclear receptor binding SET domain protein 1
NUP62 nucleoporin 62kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PALMD palmdelphin
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PLAU plasminogen activator, urokinase
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
POGK pogo transposable element with KRAB domain
PPAP2B phosphatidic acid phosphatase type 2B
RBL1 retinoblastoma-like 1
RBM23 RNA binding motif protein 23
RIN2 Ras and Rab interactor 2
SCAF8 SR-related CTD-associated factor 8
SETD1B SET domain containing 1B
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIM2 single-minded family bHLH transcription factor 2
SLC12A8 solute carrier family 12, member 8
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SNUPN snurportin 1
SOCS6 suppressor of cytokine signaling 6
SRSF8 serine/arginine-rich splicing factor 8
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TRIM45 tripartite motif containing 45
URGCP upregulator of cell proliferation
VEGFC vascular endothelial growth factor C
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR33 WD repeat domain 33
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZNF16 zinc finger protein 16
ZNF165 zinc finger protein 165
ZNF586 zinc finger protein 586
ZNF692 zinc finger protein 692
ZNF787 zinc finger protein 787
ZNF804A zinc finger protein 804A