trichostatin A-5945 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the trichostatin A-5945 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHNAK2 AHNAK nucleoprotein 2
ANGPTL4 angiopoietin-like 4
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF3 activating transcription factor 3
BAIAP3 BAI1-associated protein 3
C14ORF79 chromosome 14 open reading frame 79
C8ORF60 chromosome 8 open reading frame 60
CASC1 cancer susceptibility candidate 1
CCNA1 cyclin A1
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXADR coxsackie virus and adenovirus receptor
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DENND3 DENN/MADD domain containing 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL4 dihydropyrimidinase-like 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPOR erythropoietin receptor
FAM13A family with sequence similarity 13, member A
FAM46C family with sequence similarity 46, member C
FBP2 fructose-1,6-bisphosphatase 2
FBXL2 F-box and leucine-rich repeat protein 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GMPR guanosine monophosphate reductase
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ITM2C integral membrane protein 2C
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIF21B kinesin family member 21B
KIF5C kinesin family member 5C
LAMP3 lysosomal-associated membrane protein 3
LIMA1 LIM domain and actin binding 1
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MMD monocyte to macrophage differentiation-associated
NME5 NME/NM23 family member 5
NPC1 Niemann-Pick disease, type C1
NXN nucleoredoxin
OPTN optineurin
PADI3 peptidyl arginine deiminase, type III
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
PLLP plasmolipin
PMEL premelanosome protein
PRPH peripherin
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RIPK4 receptor-interacting serine-threonine kinase 4
RPL3L ribosomal protein L3-like
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STON1 stonin 1
SYT11 synaptotagmin XI
THEMIS2 thymocyte selection associated family member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TTLL7 tubulin tyrosine ligase-like family member 7
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
WDR19 WD repeat domain 19
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC11 zinc finger, DHHC-type containing 11
ZEB1 zinc finger E-box binding homeobox 1
ZNF10 zinc finger protein 10
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACVR2B activin A receptor, type IIB
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMIGO2 adhesion molecule with Ig-like domain 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
BATF basic leucine zipper transcription factor, ATF-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CALHM2 calcium homeostasis modulator 2
CASD1 CAS1 domain containing 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCND1 cyclin D1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
EFNA1 ephrin-A1
EGR3 early growth response 3
ELF4 E74-like factor 4 (ets domain transcription factor)
FAM155B family with sequence similarity 155, member B
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FOXC1 forkhead box C1
GATA3 GATA binding protein 3
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
GPR87 G protein-coupled receptor 87
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTF2I general transcription factor IIi
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
IL15RA interleukin 15 receptor, alpha
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
ITPKB inositol-trisphosphate 3-kinase B
JMJD4 jumonji domain containing 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0125 KIAA0125
LMNB1 lamin B1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MEPCE methylphosphate capping enzyme
METTL8 methyltransferase like 8
MEX3C mex-3 RNA binding family member C
MID1IP1 MID1 interacting protein 1
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPY5R neuropeptide Y receptor Y5
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
POGK pogo transposable element with KRAB domain
PRNP prion protein
PRR15L proline rich 15-like
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM23 RNA binding motif protein 23
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SETD1B SET domain containing 1B
SETD8 SET domain containing (lysine methyltransferase) 8
SFMBT1 Scm-like with four mbt domains 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIDT1 SID1 transmembrane family, member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SOX12 SRY (sex determining region Y)-box 12
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF4 serine/arginine-rich splicing factor 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STC2 stanniocalcin 2
TGIF1 TGFB-induced factor homeobox 1
TMEM30B transmembrane protein 30B
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM8 tripartite motif containing 8
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
UBTF upstream binding transcription factor, RNA polymerase I
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR4 WD repeat domain 4
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP30 ZFP30 zinc finger protein
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZNF573 zinc finger protein 573
ZNF692 zinc finger protein 692
ZNF710 zinc finger protein 710