trichostatin A-5822 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-5822 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
CCDC68 coiled-coil domain containing 68
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFAP69 cilia and flagella associated protein 69
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN8 claudin 8
CPM carboxypeptidase M
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EFNA3 ephrin-A3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL4 ELOVL fatty acid elongase 4
EPPK1 epiplakin 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FAM69A family with sequence similarity 69, member A
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HOXA1 homeobox A1
IL11 interleukin 11
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF5C kinesin family member 5C
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LYPD3 LY6/PLAUR domain containing 3
MAK male germ cell-associated kinase
MAP2K3 mitogen-activated protein kinase kinase 3
MAPT microtubule-associated protein tau
MERTK MER proto-oncogene, tyrosine kinase
MICA MHC class I polypeptide-related sequence A
MMP1 matrix metallopeptidase 1
MSX2 msh homeobox 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PID1 phosphotyrosine interaction domain containing 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRPH peripherin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNF24 ring finger protein 24
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC25A44 solute carrier family 25, member 44
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TBPL1 TBP-like 1
TNC tenascin C
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TPMT thiopurine S-methyltransferase
TPST2 tyrosylprotein sulfotransferase 2
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UBE2H ubiquitin-conjugating enzyme E2H
VCAN versican

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ADNP activity-dependent neuroprotector homeobox
ADORA2B adenosine A2b receptor
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARSJ arylsulfatase family, member J
ATF1 activating transcription factor 1
BANP BTG3 associated nuclear protein
BCAR3 breast cancer anti-estrogen resistance 3
BHLHE41 basic helix-loop-helix family, member e41
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CDC7 cell division cycle 7
CHKB choline kinase beta
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
DEPDC1 DEP domain containing 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DTWD1 DTW domain containing 1
FAM60A family with sequence similarity 60, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
FZD8 frizzled class receptor 8
GBX2 gastrulation brain homeobox 2
GIN1 gypsy retrotransposon integrase 1
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
HMGXB4 HMG box domain containing 4
IL7R interleukin 7 receptor
INHBB inhibin, beta B
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KIF23 kinesin family member 23
LPAR1 lysophosphatidic acid receptor 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MEPCE methylphosphate capping enzyme
METTL4 methyltransferase like 4
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MSL1 male-specific lethal 1 homolog (Drosophila)
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTRF1 mitochondrial translational release factor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRX1 NLR family member X1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NUAK1 NUAK family, SNF1-like kinase, 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PARP2 poly (ADP-ribose) polymerase 2
PARP4 poly (ADP-ribose) polymerase family, member 4
PEG3 paternally expressed 3
POGK pogo transposable element with KRAB domain
PPAN peter pan homolog (Drosophila)
PPP1R26 protein phosphatase 1, regulatory subunit 26
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RBL1 retinoblastoma-like 1
RBM39 RNA binding motif protein 39
RIN2 Ras and Rab interactor 2
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SETD6 SET domain containing 6
SIM2 single-minded family bHLH transcription factor 2
SLC35F2 solute carrier family 35, member F2
SLTM SAFB-like, transcription modulator
SMAGP small cell adhesion glycoprotein
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SOCS2 suppressor of cytokine signaling 2
SPHK1 sphingosine kinase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMED1 transmembrane emp24 protein transport domain containing 1
TRIB3 tribbles pseudokinase 3
TSSC4 tumor suppressing subtransferable candidate 4
UBIAD1 UbiA prenyltransferase domain containing 1
UBXN8 UBX domain protein 8
URGCP upregulator of cell proliferation
VEGFC vascular endothelial growth factor C
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
VWA9 von Willebrand factor A domain containing 9
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR74 WD repeat domain 74
XBP1 X-box binding protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZC3H7A zinc finger CCCH-type containing 7A
ZNF248 zinc finger protein 248
ZNF532 zinc finger protein 532
ZZZ3 zinc finger, ZZ-type containing 3