trichostatin A-5745 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-5745 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRB2 adhesion G protein-coupled receptor B2
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
CA5B carbonic anhydrase VB, mitochondrial
CCNA1 cyclin A1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP69 cilia and flagella associated protein 69
CLTCL1 clathrin, heavy chain-like 1
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL4 ELOVL fatty acid elongase 4
EPHB3 EPH receptor B3
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
H1FX H1 histone family, member X
HAP1 huntingtin-associated protein 1
HOXA1 homeobox A1
IGSF6 immunoglobulin superfamily, member 6
INSIG1 insulin induced gene 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK2 potassium channel, two pore domain subfamily K, member 2
KIF5C kinesin family member 5C
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
MAK male germ cell-associated kinase
MAST3 microtubule associated serine/threonine kinase 3
MERTK MER proto-oncogene, tyrosine kinase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MSX2 msh homeobox 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRXN3 neurexin 3
OASL 2'-5'-oligoadenylate synthetase-like
ONECUT2 one cut homeobox 2
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPH peripherin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RND1 Rho family GTPase 1
RNF24 ring finger protein 24
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORBS1 sorbin and SH3 domain containing 1
SOX15 SRY (sex determining region Y)-box 15
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STON1 stonin 1
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TAOK3 TAO kinase 3
TM7SF2 transmembrane 7 superfamily member 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPMT thiopurine S-methyltransferase
TRAFD1 TRAF-type zinc finger domain containing 1
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ATF1 activating transcription factor 1
BCAR3 breast cancer anti-estrogen resistance 3
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
C19ORF40 chromosome 19 open reading frame 40
C19ORF54 chromosome 19 open reading frame 54
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CLCF1 cardiotrophin-like cytokine factor 1
CLDN14 claudin 14
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
DEPDC1 DEP domain containing 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
E2F8 E2F transcription factor 8
EGF epidermal growth factor
FADD Fas (TNFRSF6)-associated via death domain
FAM57A family with sequence similarity 57, member A
FOXA1 forkhead box A1
FST follistatin
FZD8 frizzled class receptor 8
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GTF2I general transcription factor IIi
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
IL7R interleukin 7 receptor
INHBB inhibin, beta B
IREB2 iron-responsive element binding protein 2
ITPKB inositol-trisphosphate 3-kinase B
JADE1 jade family PHD finger 1
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRRC37A3 leucine rich repeat containing 37, member A3
LUC7L2 LUC7-like 2 (S. cerevisiae)
MCM9 minichromosome maintenance complex component 9
MEPCE methylphosphate capping enzyme
MON1B MON1 secretory trafficking family member B
MSL1 male-specific lethal 1 homolog (Drosophila)
NCS1 neuronal calcium sensor 1
NLRX1 NLR family member X1
NMI N-myc (and STAT) interactor
NOD1 nucleotide-binding oligomerization domain containing 1
NRIP1 nuclear receptor interacting protein 1
NSD1 nuclear receptor binding SET domain protein 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALMD palmdelphin
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PEG3 paternally expressed 3
PLAU plasminogen activator, urokinase
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POGK pogo transposable element with KRAB domain
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PXDC1 PX domain containing 1
RBM4B RNA binding motif protein 4B
RIN2 Ras and Rab interactor 2
SCAF8 SR-related CTD-associated factor 8
SETMAR SET domain and mariner transposase fusion gene
SH2D4A SH2 domain containing 4A
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIM2 single-minded family bHLH transcription factor 2
SMAGP small cell adhesion glycoprotein
SMG9 SMG9 nonsense mediated mRNA decay factor
SRSF4 serine/arginine-rich splicing factor 4
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THAP1 THAP domain containing, apoptosis associated protein 1
TMEM242 transmembrane protein 242
TMPO thymopoietin
TOE1 target of EGR1, member 1 (nuclear)
TRIB3 tribbles pseudokinase 3
TSSC4 tumor suppressing subtransferable candidate 4
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
WDR43 WD repeat domain 43
ZC3H4 zinc finger CCCH-type containing 4
ZC3H7A zinc finger CCCH-type containing 7A
ZNF227 zinc finger protein 227
ZNF282 zinc finger protein 282
ZNF32 zinc finger protein 32
ZNF33B zinc finger protein 33B
ZNF692 zinc finger protein 692
ZNF787 zinc finger protein 787
ZNF804A zinc finger protein 804A
ZNHIT2 zinc finger, HIT-type containing 2
ZSCAN31 zinc finger and SCAN domain containing 31
ZZZ3 zinc finger, ZZ-type containing 3