trichostatin A-5511 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-5511 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSF2 acyl-CoA synthetase family member 2
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ARMCX2 armadillo repeat containing, X-linked 2
BEX4 brain expressed, X-linked 4
BLVRA biliverdin reductase A
BTN2A2 butyrophilin, subfamily 2, member A2
C16ORF45 chromosome 16 open reading frame 45
CDH18 cadherin 18, type 2
CEP112 centrosomal protein 112kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLGN calmegin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXADR coxsackie virus and adenovirus receptor
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL4 dihydropyrimidinase-like 4
DUSP10 dual specificity phosphatase 10
EFNA3 ephrin-A3
EFNB3 ephrin-B3
ELOVL4 ELOVL fatty acid elongase 4
FAM105A family with sequence similarity 105, member A
FAM13A family with sequence similarity 13, member A
FAM46C family with sequence similarity 46, member C
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GCHFR GTP cyclohydrolase I feedback regulator
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KIF21B kinesin family member 21B
KIF5C kinesin family member 5C
LIMA1 LIM domain and actin binding 1
LINC00341 long intergenic non-protein coding RNA 341
LYST lysosomal trafficking regulator
MAP1B microtubule-associated protein 1B
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MXI1 MAX interactor 1, dimerization protein
NAP1L3 nucleosome assembly protein 1-like 3
NES nestin
NPC1 Niemann-Pick disease, type C1
NRTN neurturin
NXN nucleoredoxin
OSBPL10 oxysterol binding protein-like 10
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPARD peroxisome proliferator-activated receptor delta
PRPH peripherin
RAI2 retinoic acid induced 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RIPK4 receptor-interacting serine-threonine kinase 4
RND1 Rho family GTPase 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNDC3B RUN domain containing 3B
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMTN smoothelin
SOX9 SRY (sex determining region Y)-box 9
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STON1 stonin 1
STXBP1 syntaxin binding protein 1
SYBU syntabulin (syntaxin-interacting)
SYT11 synaptotagmin XI
TBXA2R thromboxane A2 receptor
TMSB15A thymosin beta 15a
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UNC119 unc-119 homolog (C. elegans)
WDR19 WD repeat domain 19
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF10 zinc finger protein 10
ZNF204P zinc finger protein 204, pseudogene
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARMC6 armadillo repeat containing 6
ATAD2B ATPase family, AAA domain containing 2B
BANP BTG3 associated nuclear protein
BCAR3 breast cancer anti-estrogen resistance 3
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C9ORF91 chromosome 9 open reading frame 91
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCND1 cyclin D1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CISH cytokine inducible SH2-containing protein
CLK1 CDC-like kinase 1
COIL coilin
CTAGE9 CTAGE family, member 9
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
EGR3 early growth response 3
FAM53B family with sequence similarity 53, member B
FAM57A family with sequence similarity 57, member A
FHOD1 formin homology 2 domain containing 1
FJX1 four jointed box 1 (Drosophila)
GATA3 GATA binding protein 3
GTF2I general transcription factor IIi
HIRIP3 HIRA interacting protein 3
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRS1 insulin receptor substrate 1
IRX4 iroquois homeobox 4
IRX5 iroquois homeobox 5
KAT2A K(lysine) acetyltransferase 2A
KCTD15 potassium channel tetramerization domain containing 15
KEAP1 kelch-like ECH-associated protein 1
LOXL1 lysyl oxidase-like 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY6G5C lymphocyte antigen 6 complex, locus G5C
MARC1 mitochondrial amidoxime reducing component 1
MCM9 minichromosome maintenance complex component 9
MEPCE methylphosphate capping enzyme
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPH non-SMC condensin I complex, subunit H
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUAK1 NUAK family, SNF1-like kinase, 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PFDN1 prefoldin subunit 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POGK pogo transposable element with KRAB domain
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRR7 proline rich 7 (synaptic)
PTK6 protein tyrosine kinase 6
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PUS1 pseudouridylate synthase 1
RABL3 RAB, member of RAS oncogene family-like 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
SARS2 seryl-tRNA synthetase 2, mitochondrial
SETD1B SET domain containing 1B
SMAD7 SMAD family member 7
SMAGP small cell adhesion glycoprotein
SMYD5 SMYD family member 5
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SSFA2 sperm specific antigen 2
STAG1 stromal antigen 1
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCERG1 transcription elongation regulator 1
TGFB3 transforming growth factor, beta 3
TPTE transmembrane phosphatase with tensin homology
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM8 tripartite motif containing 8
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
UBXN8 UBX domain protein 8
UCK2 uridine-cytidine kinase 2
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF280D zinc finger protein 280D
ZNF282 zinc finger protein 282