trichostatin A-5441 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the trichostatin A-5441 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL4 angiopoietin-like 4
ARMCX2 armadillo repeat containing, X-linked 2
BAIAP3 BAI1-associated protein 3
C16ORF45 chromosome 16 open reading frame 45
CDH18 cadherin 18, type 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP112 centrosomal protein 112kDa
CLGN calmegin
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXADR coxsackie virus and adenovirus receptor
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIXDC1 DIX domain containing 1
DLX2 distal-less homeobox 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPF1 D4, zinc and double PHD fingers family 1
DPYSL4 dihydropyrimidinase-like 4
EFNB3 ephrin-B3
FAM105A family with sequence similarity 105, member A
FAM13A family with sequence similarity 13, member A
FAM46C family with sequence similarity 46, member C
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GRK5 G protein-coupled receptor kinase 5
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA1 homeobox A1
ITM2C integral membrane protein 2C
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIF13B kinesin family member 13B
KIF5C kinesin family member 5C
LIMA1 LIM domain and actin binding 1
LYST lysosomal trafficking regulator
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MXRA7 matrix-remodelling associated 7
NAP1L3 nucleosome assembly protein 1-like 3
NES nestin
NPC1 Niemann-Pick disease, type C1
NXN nucleoredoxin
OASL 2'-5'-oligoadenylate synthetase-like
PADI3 peptidyl arginine deiminase, type III
PAIP2B poly(A) binding protein interacting protein 2B
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PMEL premelanosome protein
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRPH peripherin
PTRF polymerase I and transcript release factor
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RPL3L ribosomal protein L3-like
RTN2 reticulon 2
RUNDC3B RUN domain containing 3B
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STON1 stonin 1
STX2 syntaxin 2
STXBP1 syntaxin binding protein 1
SYT11 synaptotagmin XI
TBXA2R thromboxane A2 receptor
TMSB15A thymosin beta 15a
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
ULBP2 UL16 binding protein 2
USP2 ubiquitin specific peptidase 2
WDR19 WD repeat domain 19
WDR47 WD repeat domain 47
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
ADRA2C adrenoceptor alpha 2C
AKAP8 A kinase (PRKA) anchor protein 8
AMIGO2 adhesion molecule with Ig-like domain 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BATF basic leucine zipper transcription factor, ATF-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C9ORF91 chromosome 9 open reading frame 91
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBR3 carbonyl reductase 3
CCDC94 coiled-coil domain containing 94
CCND1 cyclin D1
CCNL2 cyclin L2
CISH cytokine inducible SH2-containing protein
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
EGR3 early growth response 3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EXOSC10 exosome component 10
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
GABPB1 GA binding protein transcription factor, beta subunit 1
GMEB1 glucocorticoid modulatory element binding protein 1
GPR87 G protein-coupled receptor 87
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HIRIP3 HIRA interacting protein 3
HOXC11 homeobox C11
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
KAT2A K(lysine) acetyltransferase 2A
KEAP1 kelch-like ECH-associated protein 1
KRI1 KRI1 homolog (S. cerevisiae)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LMNB1 lamin B1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LUC7L2 LUC7-like 2 (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAGEF1 melanoma antigen family F1
MCM9 minichromosome maintenance complex component 9
MEPCE methylphosphate capping enzyme
MID1IP1 MID1 interacting protein 1
MPPED2 metallophosphoesterase domain containing 2
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PHLDA3 pleckstrin homology-like domain, family A, member 3
POGK pogo transposable element with KRAB domain
PPAN peter pan homolog (Drosophila)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM23 RNA binding motif protein 23
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCRN1 secernin 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SFMBT1 Scm-like with four mbt domains 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMYD5 SMYD family member 5
SNHG20 small nucleolar RNA host gene 20
SOX12 SRY (sex determining region Y)-box 12
SPRYD7 SPRY domain containing 7
SREK1 splicing regulatory glutamine/lysine-rich protein 1
STC2 stanniocalcin 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFB3 transforming growth factor, beta 3
TMEM30B transmembrane protein 30B
TMEM39B transmembrane protein 39B
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
TSSC4 tumor suppressing subtransferable candidate 4
TTC27 tetratricopeptide repeat domain 27
UBTF upstream binding transcription factor, RNA polymerase I
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
XBP1 X-box binding protein 1
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF675 zinc finger protein 675
ZNF692 zinc finger protein 692
ZNF787 zinc finger protein 787