trichostatin A-5231 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trichostatin A-5231 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ARMCX2 armadillo repeat containing, X-linked 2
BAIAP3 BAI1-associated protein 3
CASC1 cancer susceptibility candidate 1
CCNA1 cyclin A1
CDH18 cadherin 18, type 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP112 centrosomal protein 112kDa
CLGN calmegin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIXDC1 DIX domain containing 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL4 dihydropyrimidinase-like 4
EFNB3 ephrin-B3
EGR1 early growth response 1
ELOVL4 ELOVL fatty acid elongase 4
FAM105A family with sequence similarity 105, member A
FAM46C family with sequence similarity 46, member C
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GRAMD1C GRAM domain containing 1C
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
HBEGF heparin-binding EGF-like growth factor
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IRF7 interferon regulatory factor 7
KIF5C kinesin family member 5C
LIMA1 LIM domain and actin binding 1
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCOLN1 mucolipin 1
MMD monocyte to macrophage differentiation-associated
NAP1L3 nucleosome assembly protein 1-like 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NES nestin
NPC1 Niemann-Pick disease, type C1
NXN nucleoredoxin
OASL 2'-5'-oligoadenylate synthetase-like
PADI3 peptidyl arginine deiminase, type III
PARP16 poly (ADP-ribose) polymerase family, member 16
PDE4DIP phosphodiesterase 4D interacting protein
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKNOX2 PBX/knotted 1 homeobox 2
PLK3 polo-like kinase 3
PMEL premelanosome protein
PRPH peripherin
PTRF polymerase I and transcript release factor
RAI2 retinoic acid induced 2
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
RPL3L ribosomal protein L3-like
RTN2 reticulon 2
RUNDC3B RUN domain containing 3B
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SORBS1 sorbin and SH3 domain containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
SYT11 synaptotagmin XI
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TUFT1 tuftelin 1
ULBP2 UL16 binding protein 2
WDR19 WD repeat domain 19
WDR47 WD repeat domain 47
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF10 zinc finger protein 10
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
AMIGO2 adhesion molecule with Ig-like domain 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
BCAR3 breast cancer anti-estrogen resistance 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C9ORF91 chromosome 9 open reading frame 91
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC94 coiled-coil domain containing 94
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHMP6 charged multivesicular body protein 6
CISH cytokine inducible SH2-containing protein
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUL1 cullin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
E2F8 E2F transcription factor 8
EFNA1 ephrin-A1
EGR3 early growth response 3
ELF4 E74-like factor 4 (ets domain transcription factor)
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERBB2IP erbb2 interacting protein
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FOXC1 forkhead box C1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
HIRIP3 HIRA interacting protein 3
HMGXB4 HMG box domain containing 4
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRX4 iroquois homeobox 4
IRX5 iroquois homeobox 5
KAT2A K(lysine) acetyltransferase 2A
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0125 KIAA0125
LAMA5 laminin, alpha 5
LMNB1 lamin B1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MCM9 minichromosome maintenance complex component 9
MEPCE methylphosphate capping enzyme
METTL8 methyltransferase like 8
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARFL nuclear prelamin A recognition factor-like
NRIP1 nuclear receptor interacting protein 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PHLDA3 pleckstrin homology-like domain, family A, member 3
POGK pogo transposable element with KRAB domain
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRR15L proline rich 15-like
PUS1 pseudouridylate synthase 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SETD1B SET domain containing 1B
SFMBT1 Scm-like with four mbt domains 1
SH2D4A SH2 domain containing 4A
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMYD5 SMYD family member 5
SNHG20 small nucleolar RNA host gene 20
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF4 serine/arginine-rich splicing factor 4
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TGIF1 TGFB-induced factor homeobox 1
TMEM223 transmembrane protein 223
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNS3 tensin 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM8 tripartite motif containing 8
TSKU tsukushi, small leucine rich proteoglycan
UBL4A ubiquitin-like 4A
UBTF upstream binding transcription factor, RNA polymerase I
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR74 WD repeat domain 74
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZBED1 zinc finger, BED-type containing 1
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF692 zinc finger protein 692
ZNF787 zinc finger protein 787