trichostatin A-5086 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-5086 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADRB2 adrenoceptor beta 2, surface
AGFG2 ArfGAP with FG repeats 2
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARID5A AT rich interactive domain 5A (MRF1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
CA5B carbonic anhydrase VB, mitochondrial
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFAP69 cilia and flagella associated protein 69
CHN2 chimerin 2
CORO1A coronin, actin binding protein, 1A
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY2 cryptochrome circadian clock 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
DENND3 DENN/MADD domain containing 3
DLX2 distal-less homeobox 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNA3 ephrin-A3
EFNB2 ephrin-B2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLS glutaminase
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H1FX H1 histone family, member X
HBEGF heparin-binding EGF-like growth factor
HOXA1 homeobox A1
HSPA12A heat shock 70kDa protein 12A
IL1RAP interleukin 1 receptor accessory protein
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
ITGA7 integrin, alpha 7
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
LIMA1 LIM domain and actin binding 1
LINC00341 long intergenic non-protein coding RNA 341
LIPG lipase, endothelial
LMCD1 LIM and cysteine-rich domains 1
LPCAT3 lysophosphatidylcholine acyltransferase 3
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC1 leucine rich repeat containing 1
MAK male germ cell-associated kinase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPT microtubule-associated protein tau
MERTK MER proto-oncogene, tyrosine kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NGF nerve growth factor (beta polypeptide)
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI2 pellino E3 ubiquitin protein ligase family member 2
PLXNA3 plexin A3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPH peripherin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNF24 ring finger protein 24
RTN2 reticulon 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPB surfactant protein B
SH3GL3 SH3-domain GRB2-like 3
SORBS1 sorbin and SH3 domain containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK4 serine/threonine kinase 4
STOM stomatin
SYT1 synaptotagmin I
TAOK3 TAO kinase 3
TFR2 transferrin receptor 2
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
ZFP36 ZFP36 ring finger protein
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARSJ arylsulfatase family, member J
BCAR3 breast cancer anti-estrogen resistance 3
BCL7A B-cell CLL/lymphoma 7A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C17ORF75 chromosome 17 open reading frame 75
C9ORF91 chromosome 9 open reading frame 91
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CCDC59 coiled-coil domain containing 59
CCNT1 cyclin T1
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CYTH2 cytohesin 2
DEPDC1 DEP domain containing 1
E2F8 E2F transcription factor 8
EVPL envoplakin
EXOSC10 exosome component 10
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GTF2I general transcription factor IIi
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAS2 hyaluronan synthase 2
HDAC9 histone deacetylase 9
HMGA2 high mobility group AT-hook 2
HMGXB4 HMG box domain containing 4
IFNAR1 interferon (alpha, beta and omega) receptor 1
INHBB inhibin, beta B
KAT6B K(lysine) acetyltransferase 6B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MED18 mediator complex subunit 18
MEPCE methylphosphate capping enzyme
METTL4 methyltransferase like 4
MRPS34 mitochondrial ribosomal protein S34
MTPAP mitochondrial poly(A) polymerase
NDC80 NDC80 kinetochore complex component
NHEJ1 nonhomologous end-joining factor 1
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP4 poly (ADP-ribose) polymerase family, member 4
PEG3 paternally expressed 3
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
RBL1 retinoblastoma-like 1
RBM23 RNA binding motif protein 23
RIN2 Ras and Rab interactor 2
RPL13P5 ribosomal protein L13 pseudogene 5
SCAF8 SR-related CTD-associated factor 8
SETD1B SET domain containing 1B
SFMBT1 Scm-like with four mbt domains 1
SH2D4A SH2 domain containing 4A
SIM2 single-minded family bHLH transcription factor 2
SMAGP small cell adhesion glycoprotein
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SNUPN snurportin 1
SPIN1 spindlin 1
SPOP speckle-type POZ protein
SRSF4 serine/arginine-rich splicing factor 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TARBP2 TAR (HIV-1) RNA binding protein 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM168 transmembrane protein 168
TMEM242 transmembrane protein 242
TMEM254 transmembrane protein 254
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOE1 target of EGR1, member 1 (nuclear)
TRIM16 tripartite motif containing 16
URGCP upregulator of cell proliferation
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFC vascular endothelial growth factor C
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WDR33 WD repeat domain 33
WDR43 WD repeat domain 43
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF227 zinc finger protein 227
ZNF239 zinc finger protein 239
ZNF254 zinc finger protein 254
ZNF33B zinc finger protein 33B
ZNF675 zinc finger protein 675
ZNF692 zinc finger protein 692
ZZZ3 zinc finger, ZZ-type containing 3