trichostatin A-5065 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-5065 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BMP4 bone morphogenetic protein 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFAP69 cilia and flagella associated protein 69
CLTCL1 clathrin, heavy chain-like 1
COBL cordon-bleu WH2 repeat protein
COL21A1 collagen, type XXI, alpha 1
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
DFNB31 deafness, autosomal recessive 31
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL4 dihydropyrimidinase-like 4
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EGR2 early growth response 2
ENOX1 ecto-NOX disulfide-thiol exchanger 1
FABP4 fatty acid binding protein 4, adipocyte
FAM46C family with sequence similarity 46, member C
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GMPR guanosine monophosphate reductase
GRK5 G protein-coupled receptor kinase 5
H1FX H1 histone family, member X
IL1RAP interleukin 1 receptor accessory protein
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0513 KIAA0513
KIF5C kinesin family member 5C
LIFR leukemia inhibitory factor receptor alpha
LINC00260 long intergenic non-protein coding RNA 260
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LYST lysosomal trafficking regulator
MAP2K3 mitogen-activated protein kinase kinase 3
MAPT microtubule-associated protein tau
MARK4 MAP/microtubule affinity-regulating kinase 4
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR6A1 nuclear receptor subfamily 6, group A, member 1
PAIP2B poly(A) binding protein interacting protein 2B
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER1 period circadian clock 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PKP2 plakophilin 2
PPARD peroxisome proliferator-activated receptor delta
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNF24 ring finger protein 24
RRAGD Ras-related GTP binding D
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SKI SKI proto-oncogene
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STON1 stonin 1
SYT1 synaptotagmin I
TJP3 tight junction protein 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIK TRAF2 and NCK interacting kinase
TRAFD1 TRAF-type zinc finger domain containing 1
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ALPK1 alpha-kinase 1
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APOL6 apolipoprotein L, 6
ARMC6 armadillo repeat containing 6
BCAR3 breast cancer anti-estrogen resistance 3
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CCDC94 coiled-coil domain containing 94
CCRL2 chemokine (C-C motif) receptor-like 2
CHM choroideremia (Rab escort protein 1)
CLCF1 cardiotrophin-like cytokine factor 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CUL1 cullin 1
DCTN4 dynactin 4 (p62)
DEAF1 DEAF1 transcription factor
DEPDC1 DEP domain containing 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DUSP4 dual specificity phosphatase 4
E2F8 E2F transcription factor 8
EXOSC10 exosome component 10
FADD Fas (TNFRSF6)-associated via death domain
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBX2 gastrulation brain homeobox 2
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GTF2I general transcription factor IIi
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HIPK2 homeodomain interacting protein kinase 2
HMGA2 high mobility group AT-hook 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INHBB inhibin, beta B
KAT6B K(lysine) acetyltransferase 6B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM4D lysine (K)-specific demethylase 4D
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRRC41 leucine rich repeat containing 41
LUC7L2 LUC7-like 2 (S. cerevisiae)
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
METTL16 methyltransferase like 16
METTL4 methyltransferase like 4
NDC80 NDC80 kinetochore complex component
NDP Norrie disease (pseudoglioma)
NMI N-myc (and STAT) interactor
NUP62 nucleoporin 62kDa
NUPR1 nuclear protein, transcriptional regulator, 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PEX14 peroxisomal biogenesis factor 14
PEX26 peroxisomal biogenesis factor 26
PLAU plasminogen activator, urokinase
PMCH pro-melanin-concentrating hormone
PPAP2B phosphatidic acid phosphatase type 2B
PPCS phosphopantothenoylcysteine synthetase
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PXDC1 PX domain containing 1
QRICH1 glutamine-rich 1
RIN2 Ras and Rab interactor 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SMAGP small cell adhesion glycoprotein
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SPIN1 spindlin 1
SRSF4 serine/arginine-rich splicing factor 4
SRSF8 serine/arginine-rich splicing factor 8
STAG1 stromal antigen 1
SUGCT succinyl-CoA:glutarate-CoA transferase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TCERG1 transcription elongation regulator 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THAP1 THAP domain containing, apoptosis associated protein 1
TMEM254 transmembrane protein 254
TOE1 target of EGR1, member 1 (nuclear)
TRIM13 tripartite motif containing 13
TRIM5 tripartite motif containing 5
TTC27 tetratricopeptide repeat domain 27
TUBGCP3 tubulin, gamma complex associated protein 3
UNKL unkempt family zinc finger-like
VEGFC vascular endothelial growth factor C
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC10 zinc finger, CCHC domain containing 10
ZNF165 zinc finger protein 165
ZNF668 zinc finger protein 668
ZNF764 zinc finger protein 764
ZNHIT2 zinc finger, HIT-type containing 2
ZZZ3 zinc finger, ZZ-type containing 3