trichostatin A-5017 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the trichostatin A-5017 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSF2 acyl-CoA synthetase family member 2
ADM adrenomedullin
AGFG2 ArfGAP with FG repeats 2
AHDC1 AT hook, DNA binding motif, containing 1
AHNAK2 AHNAK nucleoprotein 2
APLP1 amyloid beta (A4) precursor-like protein 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAIAP3 BAI1-associated protein 3
CALCOCO1 calcium binding and coiled-coil domain 1
CLGN calmegin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP2 cysteine and glycine-rich protein 2
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DFNB31 deafness, autosomal recessive 31
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL4 dihydropyrimidinase-like 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB3 ephrin-B3
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
ETV5 ets variant 5
FAM214B family with sequence similarity 214, member B
FAM46C family with sequence similarity 46, member C
FAXDC2 fatty acid hydroxylase domain containing 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRK5 G protein-coupled receptor kinase 5
H1F0 H1 histone family, member 0
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1D histone cluster 1, H1d
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
KIF21B kinesin family member 21B
KIF5C kinesin family member 5C
LINC00341 long intergenic non-protein coding RNA 341
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP1A microtubule-associated protein 1A
MAP1B microtubule-associated protein 1B
MARK4 MAP/microtubule affinity-regulating kinase 4
MUC3B mucin 3B, cell surface associated
NES nestin
NPC1 Niemann-Pick disease, type C1
NRTN neurturin
NSUN6 NOP2/Sun domain family, member 6
NXN nucleoredoxin
PADI3 peptidyl arginine deiminase, type III
PDE4A phosphodiesterase 4A, cAMP-specific
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLLP plasmolipin
PMEL premelanosome protein
PPARD peroxisome proliferator-activated receptor delta
PRPH peripherin
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RHOBTB2 Rho-related BTB domain containing 2
RPL3L ribosomal protein L3-like
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
RUNDC3B RUN domain containing 3B
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SNN stannin
SORBS1 sorbin and SH3 domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STON1 stonin 1
STXBP1 syntaxin binding protein 1
SYT11 synaptotagmin XI
TBXA2R thromboxane A2 receptor
TMCC2 transmembrane and coiled-coil domain family 2
TMEM212 transmembrane protein 212
TPMT thiopurine S-methyltransferase
TUFT1 tuftelin 1
WDR19 WD repeat domain 19
XYLT1 xylosyltransferase I
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
ADORA2B adenosine A2b receptor
ANKFY1 ankyrin repeat and FYVE domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BATF basic leucine zipper transcription factor, ATF-like
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C16ORF59 chromosome 16 open reading frame 59
CCNL2 cyclin L2
CDC37 cell division cycle 37
CHMP6 charged multivesicular body protein 6
COIL coilin
CTPS1 CTP synthase 1
CUL1 cullin 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDA1 DET1 and DDB1 associated 1
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DTYMK deoxythymidylate kinase (thymidylate kinase)
EFNA1 ephrin-A1
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
FJX1 four jointed box 1 (Drosophila)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GMEB1 glucocorticoid modulatory element binding protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF2I general transcription factor IIi
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HIRIP3 HIRA interacting protein 3
HNRNPF heterogeneous nuclear ribonucleoprotein F
HP1BP3 heterochromatin protein 1, binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
KCTD20 potassium channel tetramerization domain containing 20
KEAP1 kelch-like ECH-associated protein 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY6G5C lymphocyte antigen 6 complex, locus G5C
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL8 methyltransferase like 8
MOCS3 molybdenum cofactor synthesis 3
MPDU1 mannose-P-dolichol utilization defect 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIP7 NIP7, nucleolar pre-rRNA processing protein
NMD3 NMD3 ribosome export adaptor
NME6 NME/NM23 nucleoside diphosphate kinase 6
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5C 5', 3'-nucleotidase, cytosolic
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLK1 polo-like kinase 1
POGK pogo transposable element with KRAB domain
PPAN peter pan homolog (Drosophila)
PPAP2C phosphatidic acid phosphatase type 2C
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PUS1 pseudouridylate synthase 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF146 ring finger protein 146
SETD8 SET domain containing (lysine methyltransferase) 8
SKA1 spindle and kinetochore associated complex subunit 1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF4 serine/arginine-rich splicing factor 4
SRSF8 serine/arginine-rich splicing factor 8
STC2 stanniocalcin 2
SYTL2 synaptotagmin-like 2
TET3 tet methylcytosine dioxygenase 3
TMEM230 transmembrane protein 230
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
TSPAN1 tetraspanin 1
UBL4A ubiquitin-like 4A
UBXN8 UBX domain protein 8
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR74 WD repeat domain 74
XBP1 X-box binding protein 1
YIPF5 Yip1 domain family, member 5
ZBTB6 zinc finger and BTB domain containing 6
ZFYVE21 zinc finger, FYVE domain containing 21
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1
ZNF672 zinc finger protein 672
ZNF675 zinc finger protein 675
ZNF692 zinc finger protein 692
ZNHIT2 zinc finger, HIT-type containing 2