trichostatin A-4770 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trichostatin A-4770 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSF2 acyl-CoA synthetase family member 2
ADD3 adducin 3 (gamma)
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ARMCX2 armadillo repeat containing, X-linked 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BAIAP3 BAI1-associated protein 3
BTN3A1 butyrophilin, subfamily 3, member A1
C19ORF66 chromosome 19 open reading frame 66
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CALD1 caldesmon 1
CASC1 cancer susceptibility candidate 1
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLGN calmegin
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXADR coxsackie virus and adenovirus receptor
CYLD cylindromatosis (turban tumor syndrome)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DENND3 DENN/MADD domain containing 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL4 dihydropyrimidinase-like 4
DUSP10 dual specificity phosphatase 10
EFNA3 ephrin-A3
EFNB3 ephrin-B3
EPHB2 EPH receptor B2
EPOR erythropoietin receptor
FAM13A family with sequence similarity 13, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXA1 homeobox A1
HSPA12A heat shock 70kDa protein 12A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIF5C kinesin family member 5C
LIMA1 LIM domain and actin binding 1
LINC00341 long intergenic non-protein coding RNA 341
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST3 microtubule associated serine/threonine kinase 3
MMD monocyte to macrophage differentiation-associated
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MXI1 MAX interactor 1, dimerization protein
NES nestin
NPC1 Niemann-Pick disease, type C1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NXN nucleoredoxin
OLFML2A olfactomedin-like 2A
PAIP2B poly(A) binding protein interacting protein 2B
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKNOX2 PBX/knotted 1 homeobox 2
PLAC1 placenta-specific 1
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRPH peripherin
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAB40B RAB40B, member RAS oncogene family
RAI2 retinoic acid induced 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RPL3L ribosomal protein L3-like
RUNDC3B RUN domain containing 3B
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STON1 stonin 1
STXBP1 syntaxin binding protein 1
SYT11 synaptotagmin XI
TBXA2R thromboxane A2 receptor
TMPRSS4 transmembrane protease, serine 4
TUFT1 tuftelin 1
UPK3A uroplakin 3A
WDR47 WD repeat domain 47
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF10 zinc finger protein 10
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
AMIGO2 adhesion molecule with Ig-like domain 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
BCAR3 breast cancer anti-estrogen resistance 3
BCL2L2 BCL2-like 2
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRIX1 BRX1, biogenesis of ribosomes
C9ORF91 chromosome 9 open reading frame 91
CALHM2 calcium homeostasis modulator 2
CARD8 caspase recruitment domain family, member 8
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCND1 cyclin D1
CDC7 cell division cycle 7
CDT1 chromatin licensing and DNA replication factor 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
COIL coilin
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
EGR3 early growth response 3
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOXD1 forkhead box D1
FXN frataxin
GABPB1 GA binding protein transcription factor, beta subunit 1
GPHN gephyrin
HIRIP3 HIRA interacting protein 3
INHBB inhibin, beta B
IRF2 interferon regulatory factor 2
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
KEAP1 kelch-like ECH-associated protein 1
KIAA0125 KIAA0125
LMNB1 lamin B1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LUC7L2 LUC7-like 2 (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
MEPCE methylphosphate capping enzyme
METTL4 methyltransferase like 4
MPDU1 mannose-P-dolichol utilization defect 1
MSL1 male-specific lethal 1 homolog (Drosophila)
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUAK1 NUAK family, SNF1-like kinase, 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
POGK pogo transposable element with KRAB domain
PPAN peter pan homolog (Drosophila)
PTBP2 polypyrimidine tract binding protein 2
PUS1 pseudouridylate synthase 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBL1 retinoblastoma-like 1
RBM23 RNA binding motif protein 23
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF44 ring finger protein 44
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCRN1 secernin 1
SFMBT1 Scm-like with four mbt domains 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SMAGP small cell adhesion glycoprotein
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG9 SMG9 nonsense mediated mRNA decay factor
SNHG20 small nucleolar RNA host gene 20
SNHG3 small nucleolar RNA host gene 3
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF4 serine/arginine-rich splicing factor 4
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STC2 stanniocalcin 2
STRN4 striatin, calmodulin binding protein 4
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TCERG1 transcription elongation regulator 1
THEM6 thioesterase superfamily member 6
TKFC triokinase/FMN cyclase
TPTE transmembrane phosphatase with tensin homology
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM8 tripartite motif containing 8
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
TTC17 tetratricopeptide repeat domain 17
UBXN8 UBX domain protein 8
UCK2 uridine-cytidine kinase 2
UNKL unkempt family zinc finger-like
USP21 ubiquitin specific peptidase 21
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
VRK2 vaccinia related kinase 2
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZIC1 Zic family member 1
ZNF652 zinc finger protein 652