trichostatin A-4632 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-4632 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
AGTR1 angiotensin II receptor, type 1
AKR1C2 aldo-keto reductase family 1, member C2
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ARL14 ADP-ribosylation factor-like 14
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
CA5B carbonic anhydrase VB, mitochondrial
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFAP69 cilia and flagella associated protein 69
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHB3 EPH receptor B3
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FYN FYN proto-oncogene, Src family tyrosine kinase
GRK5 G protein-coupled receptor kinase 5
GTF2B general transcription factor IIB
HBEGF heparin-binding EGF-like growth factor
HOXA1 homeobox A1
IRF6 interferon regulatory factor 6
JARID2 jumonji, AT rich interactive domain 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM4B lysine (K)-specific demethylase 4B
KIF5C kinesin family member 5C
LIFR leukemia inhibitory factor receptor alpha
LIMA1 LIM domain and actin binding 1
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAP2K3 mitogen-activated protein kinase kinase 3
MTUS1 microtubule associated tumor suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDB1 pleckstrin homology-like domain, family B, member 1
PKP2 plakophilin 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK2 polo-like kinase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNF24 ring finger protein 24
SAMD4A sterile alpha motif domain containing 4A
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STOM stomatin
STON1 stonin 1
SYT1 synaptotagmin I
TAGLN3 transgelin 3
TAOK3 TAO kinase 3
TAPBP TAP binding protein (tapasin)
TESK2 testis-specific kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIK TRAF2 and NCK interacting kinase
TRAFD1 TRAF-type zinc finger domain containing 1
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AP4M1 adaptor-related protein complex 4, mu 1 subunit
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ATF1 activating transcription factor 1
BANP BTG3 associated nuclear protein
BCAR3 breast cancer anti-estrogen resistance 3
C10ORF88 chromosome 10 open reading frame 88
C19ORF54 chromosome 19 open reading frame 54
C7ORF69 chromosome 7 open reading frame 69
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC7 cell division cycle 7
CLCF1 cardiotrophin-like cytokine factor 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
DEPDC1 DEP domain containing 1
DOLPP1 dolichyldiphosphatase 1
DUSP4 dual specificity phosphatase 4
E2F8 E2F transcription factor 8
EN1 engrailed homeobox 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBX2 gastrulation brain homeobox 2
GLMN glomulin, FKBP associated protein
HAS2 hyaluronan synthase 2
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
HMGXB4 HMG box domain containing 4
INHBB inhibin, beta B
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRS1 insulin receptor substrate 1
KAT6B K(lysine) acetyltransferase 6B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MED18 mediator complex subunit 18
MEPCE methylphosphate capping enzyme
MSL1 male-specific lethal 1 homolog (Drosophila)
NDP Norrie disease (pseudoglioma)
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPAN peter pan homolog (Drosophila)
PPAP2B phosphatidic acid phosphatase type 2B
PPCDC phosphopantothenoylcysteine decarboxylase
PPP1R8 protein phosphatase 1, regulatory subunit 8
RBL1 retinoblastoma-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RCOR3 REST corepressor 3
RIN2 Ras and Rab interactor 2
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SAYSD1 SAYSVFN motif domain containing 1
SCAF8 SR-related CTD-associated factor 8
SCN1B sodium channel, voltage gated, type I beta subunit
SETD1B SET domain containing 1B
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLTM SAFB-like, transcription modulator
SMAGP small cell adhesion glycoprotein
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG9 SMG9 nonsense mediated mRNA decay factor
SNHG3 small nucleolar RNA host gene 3
SNUPN snurportin 1
SRSF4 serine/arginine-rich splicing factor 4
STBD1 starch binding domain 1
STK16 serine/threonine kinase 16
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM53 transmembrane protein 53
TOE1 target of EGR1, member 1 (nuclear)
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TSSC4 tumor suppressing subtransferable candidate 4
TUBGCP3 tubulin, gamma complex associated protein 3
UBXN8 UBX domain protein 8
URGCP upregulator of cell proliferation
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
VWA9 von Willebrand factor A domain containing 9
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP69B ZFP69 zinc finger protein B
ZNF165 zinc finger protein 165
ZNF33B zinc finger protein 33B
ZNF562 zinc finger protein 562
ZNF668 zinc finger protein 668
ZNF787 zinc finger protein 787
ZNF804A zinc finger protein 804A
ZNHIT2 zinc finger, HIT-type containing 2
ZZZ3 zinc finger, ZZ-type containing 3