trichostatin A-4458 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-4458 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
C18ORF8 chromosome 18 open reading frame 8
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCDC64 coiled-coil domain containing 64
CCNA1 cyclin A1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFAP69 cilia and flagella associated protein 69
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLDN8 claudin 8
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNB2 ephrin-B2
EGR2 early growth response 2
EIF5A2 eukaryotic translation initiation factor 5A2
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FOS FBJ murine osteosarcoma viral oncogene homolog
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLS glutaminase
GMCL1 germ cell-less, spermatogenesis associated 1
GMPR guanosine monophosphate reductase
GRK5 G protein-coupled receptor kinase 5
HOXA1 homeobox A1
IL11 interleukin 11
IL1RAP interleukin 1 receptor accessory protein
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
LINC00312 long intergenic non-protein coding RNA 312
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MMP1 matrix metallopeptidase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
OASL 2'-5'-oligoadenylate synthetase-like
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PLLP plasmolipin
PLXNA3 plexin A3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROX1 prospero homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RND1 Rho family GTPase 1
RUNDC3A RUN domain containing 3A
RUNDC3B RUN domain containing 3B
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORBS1 sorbin and SH3 domain containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK17B serine/threonine kinase 17b
STOM stomatin
STOML1 stomatin (EPB72)-like 1
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TFEC transcription factor EC
TRAFD1 TRAF-type zinc finger domain containing 1
TTLL3 tubulin tyrosine ligase-like family member 3
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
VWA5A von Willebrand factor A domain containing 5A
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ARSJ arylsulfatase family, member J
BCAR3 breast cancer anti-estrogen resistance 3
C19ORF54 chromosome 19 open reading frame 54
C7ORF49 chromosome 7 open reading frame 49
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CCDC94 coiled-coil domain containing 94
CCNO cyclin O
CDC7 cell division cycle 7
CHKB choline kinase beta
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUL1 cullin 1
DUSP4 dual specificity phosphatase 4
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GMEB1 glucocorticoid modulatory element binding protein 1
GPR39 G protein-coupled receptor 39
GRPR gastrin-releasing peptide receptor
GTF2IRD1 GTF2I repeat domain containing 1
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
HOXC13 homeobox C13
IFI44L interferon-induced protein 44-like
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INHBB inhibin, beta B
ITPKB inositol-trisphosphate 3-kinase B
KAT6B K(lysine) acetyltransferase 6B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
KRT15 keratin 15, type I
LIF leukemia inhibitory factor
LPAR1 lysophosphatidic acid receptor 1
LRRC41 leucine rich repeat containing 41
LUC7L2 LUC7-like 2 (S. cerevisiae)
MEPCE methylphosphate capping enzyme
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MSL1 male-specific lethal 1 homolog (Drosophila)
MTA2 metastasis associated 1 family, member 2
NDC80 NDC80 kinetochore complex component
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NRIP1 nuclear receptor interacting protein 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALMD palmdelphin
PCOLCE procollagen C-endopeptidase enhancer
PLAU plasminogen activator, urokinase
POGK pogo transposable element with KRAB domain
PPAP2B phosphatidic acid phosphatase type 2B
PRICKLE3 prickle homolog 3 (Drosophila)
PXDC1 PX domain containing 1
RAD51D RAD51 paralog D
RIN2 Ras and Rab interactor 2
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAF8 SR-related CTD-associated factor 8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SLC12A8 solute carrier family 12, member 8
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMAGP small cell adhesion glycoprotein
SNHG20 small nucleolar RNA host gene 20
SPHK1 sphingosine kinase 1
SRSF4 serine/arginine-rich splicing factor 4
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TRIB3 tribbles pseudokinase 3
TRIM5 tripartite motif containing 5
TRIM8 tripartite motif containing 8
TUBGCP3 tubulin, gamma complex associated protein 3
UBTF upstream binding transcription factor, RNA polymerase I
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
WDR25 WD repeat domain 25
XBP1 X-box binding protein 1
YY2 YY2 transcription factor
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP69B ZFP69 zinc finger protein B
ZNF165 zinc finger protein 165
ZNF239 zinc finger protein 239
ZNF248 zinc finger protein 248
ZNF33B zinc finger protein 33B
ZNF532 zinc finger protein 532
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675
ZNF692 zinc finger protein 692
ZNF787 zinc finger protein 787
ZZZ3 zinc finger, ZZ-type containing 3