trichostatin A-4436 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the trichostatin A-4436 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
AGTR1 angiotensin II receptor, type 1
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ASMTL acetylserotonin O-methyltransferase-like
BAMBI BMP and activin membrane-bound inhibitor
BMP6 bone morphogenetic protein 6
CADM1 cell adhesion molecule 1
CCDC68 coiled-coil domain containing 68
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK20 cyclin-dependent kinase 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFAP69 cilia and flagella associated protein 69
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR2 early growth response 2
ELOVL4 ELOVL fatty acid elongase 4
EPHB3 EPH receptor B3
FABP4 fatty acid binding protein 4, adipocyte
GMPR guanosine monophosphate reductase
GRK5 G protein-coupled receptor kinase 5
HAP1 huntingtin-associated protein 1
HOXA1 homeobox A1
ITGA7 integrin, alpha 7
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0513 KIAA0513
KIAA0930 KIAA0930
KIF13B kinesin family member 13B
KIF5C kinesin family member 5C
KLHL25 kelch-like family member 25
LIFR leukemia inhibitory factor receptor alpha
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAK male germ cell-associated kinase
MAP2 microtubule-associated protein 2
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MERTK MER proto-oncogene, tyrosine kinase
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MSX2 msh homeobox 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OASL 2'-5'-oligoadenylate synthetase-like
ODF2 outer dense fiber of sperm tails 2
PCDH7 protocadherin 7
PDE4DIP phosphodiesterase 4D interacting protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTK2B protein tyrosine kinase 2 beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STOM stomatin
STON1 stonin 1
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TAOK3 TAO kinase 3
TCF3 transcription factor 3
THEMIS2 thymocyte selection associated family member 2
TJP3 tight junction protein 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOM1L2 target of myb1-like 2 (chicken)
TPPP tubulin polymerization promoting protein
TRIM36 tripartite motif containing 36
TTC21B tetratricopeptide repeat domain 21B
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
USP29 ubiquitin specific peptidase 29
VIPR1 vasoactive intestinal peptide receptor 1
VWA5A von Willebrand factor A domain containing 5A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
BCAR3 breast cancer anti-estrogen resistance 3
C19ORF54 chromosome 19 open reading frame 54
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CHM choroideremia (Rab escort protein 1)
CLCF1 cardiotrophin-like cytokine factor 1
COIL coilin
CTCF CCCTC-binding factor (zinc finger protein)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC2 excision repair cross-complementation group 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EXOSC10 exosome component 10
FAM57A family with sequence similarity 57, member A
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FST follistatin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GMEB1 glucocorticoid modulatory element binding protein 1
GRPR gastrin-releasing peptide receptor
GTF2I general transcription factor IIi
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL17RB interleukin 17 receptor B
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
INHBB inhibin, beta B
KAT6B K(lysine) acetyltransferase 6B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM4D lysine (K)-specific demethylase 4D
KEAP1 kelch-like ECH-associated protein 1
KLF11 Kruppel-like factor 11
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC41 leucine rich repeat containing 41
LY6G5C lymphocyte antigen 6 complex, locus G5C
MEPCE methylphosphate capping enzyme
METTL8 methyltransferase like 8
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMI N-myc (and STAT) interactor
NOD1 nucleotide-binding oligomerization domain containing 1
PALMD palmdelphin
PHF11 PHD finger protein 11
PPAP2B phosphatidic acid phosphatase type 2B
RAP1GAP2 RAP1 GTPase activating protein 2
RBM4B RNA binding motif protein 4B
RIN2 Ras and Rab interactor 2
RPIA ribose 5-phosphate isomerase A
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SLC12A8 solute carrier family 12, member 8
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMAGP small cell adhesion glycoprotein
SMYD5 SMYD family member 5
SPHK1 sphingosine kinase 1
TARBP2 TAR (HIV-1) RNA binding protein 2
TCEAL1 transcription elongation factor A (SII)-like 1
TENM4 teneurin transmembrane protein 4
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSSC4 tumor suppressing subtransferable candidate 4
TTC27 tetratricopeptide repeat domain 27
TUBGCP3 tubulin, gamma complex associated protein 3
UNKL unkempt family zinc finger-like
VEGFC vascular endothelial growth factor C
YY2 YY2 transcription factor
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZFHX3 zinc finger homeobox 3
ZFP69B ZFP69 zinc finger protein B
ZNF16 zinc finger protein 16
ZNF165 zinc finger protein 165
ZNF239 zinc finger protein 239
ZNF358 zinc finger protein 358
ZNF532 zinc finger protein 532
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZNF692 zinc finger protein 692
ZNF804A zinc finger protein 804A