trichostatin A-4344 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-4344 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APAF1 apoptotic peptidase activating factor 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ASMTL acetylserotonin O-methyltransferase-like
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFAP69 cilia and flagella associated protein 69
CLDN17 claudin 17
CLEC4E C-type lectin domain family 4, member E
CLTCL1 clathrin, heavy chain-like 1
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPF1 D4, zinc and double PHD fingers family 1
DPYSL4 dihydropyrimidinase-like 4
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNB2 ephrin-B2
EGR2 early growth response 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPPK1 epiplakin 1
EXT1 exostosin glycosyltransferase 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FGFR1 fibroblast growth factor receptor 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GMPR guanosine monophosphate reductase
HOXA1 homeobox A1
IRF6 interferon regulatory factor 6
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
KRT86 keratin 86, type II
LAT2 linker for activation of T cells family, member 2
LPPR4 lipid phosphate phosphatase-related protein type 4
LYST lysosomal trafficking regulator
MAK male germ cell-associated kinase
MAP1A microtubule-associated protein 1A
MAPT microtubule-associated protein tau
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP16 matrix metallopeptidase 16 (membrane-inserted)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFASC neurofascin
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OSR2 odd-skipped related transciption factor 2
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER1 period circadian clock 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RIMS3 regulating synaptic membrane exocytosis 3
RNF24 ring finger protein 24
RUNDC3B RUN domain containing 3B
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SIX3 SIX homeobox 3
SKI SKI proto-oncogene
SORBS1 sorbin and SH3 domain containing 1
SQLE squalene epoxidase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STOM stomatin
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TAOK3 TAO kinase 3
TBC1D2 TBC1 domain family, member 2
TBPL1 TBP-like 1
TMEM159 transmembrane protein 159
TNIK TRAF2 and NCK interacting kinase
TRIM9 tripartite motif containing 9
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
USP2 ubiquitin specific peptidase 2

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADNP activity-dependent neuroprotector homeobox
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKAP8 A kinase (PRKA) anchor protein 8
ARHGAP11A Rho GTPase activating protein 11A
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAG2 BCL2-associated athanogene 2
BCAR3 breast cancer anti-estrogen resistance 3
BRD1 bromodomain containing 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CAPN15 calpain 15
CASD1 CAS1 domain containing 1
CCDC94 coiled-coil domain containing 94
CLCF1 cardiotrophin-like cytokine factor 1
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
DCLRE1A DNA cross-link repair 1A
DCTN4 dynactin 4 (p62)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EXOC5 exocyst complex component 5
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FOXA1 forkhead box A1
FST follistatin
FZD8 frizzled class receptor 8
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GIN1 gypsy retrotransposon integrase 1
GMEB1 glucocorticoid modulatory element binding protein 1
GPR176 G protein-coupled receptor 176
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
GTPBP2 GTP binding protein 2
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INHBB inhibin, beta B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KEAP1 kelch-like ECH-associated protein 1
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LUC7L2 LUC7-like 2 (S. cerevisiae)
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEPCE methylphosphate capping enzyme
METTL4 methyltransferase like 4
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PAGR1 PAXIP1 associated glutamate-rich protein 1
PARP4 poly (ADP-ribose) polymerase family, member 4
PHF11 PHD finger protein 11
PLXNB3 plexin B3
PPP1R8 protein phosphatase 1, regulatory subunit 8
PSAT1 phosphoserine aminotransferase 1
PTK6 protein tyrosine kinase 6
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RBM23 RNA binding motif protein 23
RBM39 RNA binding motif protein 39
RBM7 RNA binding motif protein 7
RIN2 Ras and Rab interactor 2
RWDD3 RWD domain containing 3
SCAF8 SR-related CTD-associated factor 8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SETD8 SET domain containing (lysine methyltransferase) 8
SFMBT1 Scm-like with four mbt domains 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIM2 single-minded family bHLH transcription factor 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SMAGP small cell adhesion glycoprotein
STBD1 starch binding domain 1
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TCEAL1 transcription elongation factor A (SII)-like 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM230 transmembrane protein 230
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM13 tripartite motif containing 13
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBGCP3 tubulin, gamma complex associated protein 3
UBXN8 UBX domain protein 8
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
WDR74 WD repeat domain 74
ZBTB1 zinc finger and BTB domain containing 1
ZBTB14 zinc finger and BTB domain containing 14
ZFP30 ZFP30 zinc finger protein
ZNF227 zinc finger protein 227
ZNF692 zinc finger protein 692
ZNF768 zinc finger protein 768
ZNF787 zinc finger protein 787
ZNF804A zinc finger protein 804A