trichostatin A-4302 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-4302 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRB2 adhesion G protein-coupled receptor B2
AGTR1 angiotensin II receptor, type 1
AIM1L absent in melanoma 1-like
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
BAIAP2 BAI1-associated protein 2
BIRC3 baculoviral IAP repeat containing 3
BMP4 bone morphogenetic protein 4
BTF3P11 basic transcription factor 3 pseudogene 11
C5ORF45 chromosome 5 open reading frame 45
CD47 CD47 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCN6 chloride channel, voltage-sensitive 6
CLDN8 claudin 8
CLTCL1 clathrin, heavy chain-like 1
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY2 cryptochrome circadian clock 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
DENND3 DENN/MADD domain containing 3
DFNB31 deafness, autosomal recessive 31
DOK4 docking protein 4
DUSP1 dual specificity phosphatase 1
ELOVL4 ELOVL fatty acid elongase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FLJ22184
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GMPR guanosine monophosphate reductase
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPRC5B G protein-coupled receptor, class C, group 5, member B
HOXA1 homeobox A1
IL1RAP interleukin 1 receptor accessory protein
IRF6 interferon regulatory factor 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF13B kinesin family member 13B
KIF5C kinesin family member 5C
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTB4R leukotriene B4 receptor
LUM lumican
MAP1A microtubule-associated protein 1A
MAP2 microtubule-associated protein 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MERTK MER proto-oncogene, tyrosine kinase
MMP15 matrix metallopeptidase 15 (membrane-inserted)
NOL4 nucleolar protein 4
PBX2 pre-B-cell leukemia homeobox 2
PCDH7 protocadherin 7
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PELI2 pellino E3 ubiquitin protein ligase family member 2
PPL periplakin
PQLC1 PQ loop repeat containing 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPH peripherin
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAI2 retinoic acid induced 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3GL3 SH3-domain GRB2-like 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SORBS1 sorbin and SH3 domain containing 1
SOSTDC1 sclerostin domain containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT4 signal transducer and activator of transcription 4
STC1 stanniocalcin 1
SYT1 synaptotagmin I
SYT11 synaptotagmin XI
TAOK3 TAO kinase 3
TBC1D16 TBC1 domain family, member 16
TJP3 tight junction protein 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM36 tripartite motif containing 36
TRIM62 tripartite motif containing 62
TRIM9 tripartite motif containing 9
TTC21B tetratricopeptide repeat domain 21B
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM15 ADAM metallopeptidase domain 15
ADNP activity-dependent neuroprotector homeobox
ANKRD36B ankyrin repeat domain 36B
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARSJ arylsulfatase family, member J
BCAR3 breast cancer anti-estrogen resistance 3
BCAS3 breast carcinoma amplified sequence 3
CBR3 carbonyl reductase 3
CCDC15 coiled-coil domain containing 15
CCDC88A coiled-coil domain containing 88A
CCNT1 cyclin T1
COA7 cytochrome c oxidase assembly factor 7 (putative)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CUL1 cullin 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCTN4 dynactin 4 (p62)
DENND5B DENN/MADD domain containing 5B
DEPDC1 DEP domain containing 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EXOC5 exocyst complex component 5
FAM169A family with sequence similarity 169, member A
FJX1 four jointed box 1 (Drosophila)
FNDC3B fibronectin type III domain containing 3B
FZD8 frizzled class receptor 8
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GBX2 gastrulation brain homeobox 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAS2 hyaluronan synthase 2
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
INHBB inhibin, beta B
IPP intracisternal A particle-promoted polypeptide
KAT6B K(lysine) acetyltransferase 6B
KCTD15 potassium channel tetramerization domain containing 15
KEAP1 kelch-like ECH-associated protein 1
KIRREL kin of IRRE like (Drosophila)
LMNB1 lamin B1
MEPCE methylphosphate capping enzyme
MIS18BP1 MIS18 binding protein 1
MPDU1 mannose-P-dolichol utilization defect 1
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSL1 male-specific lethal 1 homolog (Drosophila)
MTPAP mitochondrial poly(A) polymerase
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NHEJ1 nonhomologous end-joining factor 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRR3 proline rich 3
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTK6 protein tyrosine kinase 6
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBBP5 retinoblastoma binding protein 5
RBM41 RNA binding motif protein 41
RBM4B RNA binding motif protein 4B
RIN2 Ras and Rab interactor 2
RNF146 ring finger protein 146
RSRC1 arginine/serine-rich coiled-coil 1
SCRN3 secernin 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SETD1B SET domain containing 1B
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SPIN1 spindlin 1
SPOP speckle-type POZ protein
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM230 transmembrane protein 230
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRIM16 tripartite motif containing 16
UBE2M ubiquitin-conjugating enzyme E2M
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VEGFC vascular endothelial growth factor C
YIPF5 Yip1 domain family, member 5
ZBTB38 zinc finger and BTB domain containing 38
ZNF124 zinc finger protein 124
ZNF148 zinc finger protein 148
ZNF532 zinc finger protein 532
ZNF562 zinc finger protein 562
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNF770 zinc finger protein 770
ZNF91 zinc finger protein 91
ZWILCH zwilch kinetochore protein